Gene/Proteome Database (LMPD)

LMPD ID
LMP000370
Gene ID
27226
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Gene Symbol
Pla2g7
Synonyms
R75400
Alternate Names
platelet-activating factor acetylhydrolase; LDL-PLA(2); PAF 2-acylhydrolase; PAF acetylhydrolase; LDL-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase
Chromosome
17
Map Location
17|17 C
EC Number
3.1.1.47

Proteins

platelet-activating factor acetylhydrolase precursor
Refseq ID NP_038765
Protein GI 31980752
UniProt ID Q60963
mRNA ID NM_013737
Length 440
RefSeq Status VALIDATED
MVPLKLQALFCLLCCLPWVHPFHWQDTSSFDFRPSVMFHKLQSVMSAAGSGHSKIPKGNGSYPVGCTDLMFGYGNESVFVRLYYPAQDQGRLDTVWIPNKEYFLGLSIFLGTPSIVGNILHLLYGSLTTPASWNSPLRTGEKYPLIVFSHGLGAFRTIYSAIGIGLASNGFIVATVEHRDRSASATYFFEDQVAAKVENRSWLYLRKVKQEESESVRKEQVQQRAIECSRALSAILDIEHGDPKENVLGSAFDMKQLKDAIDETKIALMGHSFGGATVLQALSEDQRFRCGVALDPWMYPVNEELYSRTLQPLLFINSAKFQTPKDIAKMKKFYQPDKERKMITIKGSVHQNFDDFTFVTGKIIGNKLTLKGEIDSRVAIDLTNKASMAFLQKHLGLQKDFDQWDPLVEGDDENLIPGSPFDAVTQVPAQQHSPGSQTQN
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2425 peptide sequence: MVPLKLQALFCLLCCLPWVHP mat_peptide: 22..440 product: Platelet-activating factor acetylhydrolase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q60963.2) calculated_mol_wt: 46851 peptide sequence: FHWQDTSSFDFRPSVMFHKLQSVMSAAGSGHSKIPKGNGSYPVGCTDLMFGYGNESVFVRLYYPAQDQGRLDTVWIPNKEYFLGLSIFLGTPSIVGNILHLLYGSLTTPASWNSPLRTGEKYPLIVFSHGLGAFRTIYSAIGIGLASNGFIVATVEHRDRSASATYFFEDQVAAKVENRSWLYLRKVKQEESESVRKEQVQQRAIECSRALSAILDIEHGDPKENVLGSAFDMKQLKDAIDETKIALMGHSFGGATVLQALSEDQRFRCGVALDPWMYPVNEELYSRTLQPLLFINSAKFQTPKDIAKMKKFYQPDKERKMITIKGSVHQNFDDFTFVTGKIIGNKLTLKGEIDSRVAIDLTNKASMAFLQKHLGLQKDFDQWDPLVEGDDENLIPGSPFDAVTQVPAQQHSPGSQTQN

Gene Information

Entrez Gene ID
27226
Gene Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Gene Symbol
Pla2g7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0034362 IEA:Ensembl C low-density lipoprotein particle
GO:0003847 IEA:UniProtKB-EC F 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0047499 IEA:Ensembl F calcium-independent phospholipase A2 activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0006954 TAS:MGI P inflammatory response
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0034440 IEA:Ensembl P lipid oxidation
GO:0034374 IEA:Ensembl P low-density lipoprotein particle remodeling
GO:0034441 IEA:Ensembl P plasma lipoprotein particle oxidation
GO:0090026 IEA:Ensembl P positive regulation of monocyte chemotaxis

KEGG Pathway Links

KEGG Pathway ID Description
mmu00565 Ether lipid metabolism
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893605 Peptide hormone metabolism
5893763 Synthesis, secretion, and deacylation of Ghrelin

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR005065 Platelet-activating factor acetylhydrolase
IPR016715 Platelet-activating factor acetylhydrolase, eucaryote

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Protein Entry
PAFA_MOUSE
UniProt ID
Q60963
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
Function Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Sequence Caution Sequence=AAC52274.1; Type=Frameshift; Positions=342, 349; Evidence={ECO:0000305};
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular Location Secreted, extracellular space.
Tissue Specificity Plasma.

Identical and Related Proteins

Unique RefSeq proteins for LMP000370 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31980752 RefSeq NP_038765 440 platelet-activating factor acetylhydrolase precursor

Identical Sequences to LMP000370 proteins

Reference Database Accession Length Protein Name
GI:31980752 DBBJ BAC34647.1 440 unnamed protein product [Mus musculus]
GI:31980752 GenBank AEU43345.1 440 Sequence 94 from patent US 8052970
GI:31980752 RefSeq XP_006524428.1 440 PREDICTED: platelet-activating factor acetylhydrolase isoform X1 [Mus musculus]
GI:31980752 RefSeq XP_006524429.1 440 PREDICTED: platelet-activating factor acetylhydrolase isoform X2 [Mus musculus]
GI:31980752 SwissProt Q60963.2 440 RecName: Full=Platelet-activating factor acetylhydrolase; Short=PAF acetylhydrolase; AltName: Full=1-alkyl-2-acetylglycerophosphocholine esterase; AltName: Full=2-acetyl-1-alkylglycerophosphocholine esterase; AltName: Full=LDL-associated phospholipase A2; Short=LDL-PLA(2); AltName: Full=PAF 2-acylhydrolase; Flags: Precursor [Mus musculus]

Related Sequences to LMP000370 proteins

Reference Database Accession Length Protein Name
GI:31980752 GenBank AAE20228.1 440 Sequence 31 from patent US 5847088
GI:31980752 GenBank AAH10726.1 440 Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus]
GI:31980752 GenBank EDL23404.1 440 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), isoform CRA_a [Mus musculus]
GI:31980752 GenBank EDL23406.1 440 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), isoform CRA_a [Mus musculus]
GI:31980752 GenBank AEU43377.1 440 Sequence 126 from patent US 8052970
GI:31980752 pat US 440 Sequence 27 from patent US 5698403