Gene/Proteome Database (LMPD)
LMPD ID
LMP000381
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipid scramblase 1
Gene Symbol
Synonyms
MMTRA1B
Alternate Names
phospholipid scramblase 1; PL scramblase 1; erythrocyte phospholipid scramblase; ca(2+)-dependent phospholipid scramblase 1
Chromosome
3
Map Location
3q23
Proteins
| phospholipid scramblase 1 | |
|---|---|
| Refseq ID | NP_066928 |
| Protein GI | 10863877 |
| UniProt ID | O15162 |
| mRNA ID | NM_021105 |
| Length | 318 |
| RefSeq Status | VALIDATED |
| MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:UniProtKB | C | Golgi apparatus |
| GO:0005829 | IDA:UniProtKB | C | cytosol |
| GO:0031012 | IDA:UniProtKB | C | extracellular matrix |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0005887 | IDA:UniProtKB | C | integral component of plasma membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0045121 | IDA:UniProtKB | C | membrane raft |
| GO:0005730 | IDA:UniProtKB | C | nucleolus |
| GO:0005634 | IDA:UniProtKB | C | nucleus |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0042609 | IPI:UniProtKB | F | CD4 receptor binding |
| GO:0003677 | IEA:UniProtKB-KW | F | DNA binding |
| GO:0001077 | IDA:UniProtKB | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
| GO:0017124 | IDA:UniProtKB | F | SH3 domain binding |
| GO:0005509 | IDA:UniProtKB | F | calcium ion binding |
| GO:0019899 | IPI:UniProtKB | F | enzyme binding |
| GO:0005154 | IPI:UniProtKB | F | epidermal growth factor receptor binding |
| GO:0017128 | IDA:UniProtKB | F | phospholipid scramblase activity |
| GO:0006953 | ISS:UniProtKB | P | acute-phase response |
| GO:0006915 | IDA:UniProtKB | P | apoptotic process |
| GO:0051607 | IMP:UniProtKB | P | defense response to virus |
| GO:0045071 | IMP:UniProtKB | P | negative regulation of viral genome replication |
| GO:0006659 | ISS:UniProtKB | P | phosphatidylserine biosynthetic process |
| GO:0017121 | IDA:UniProtKB | P | phospholipid scrambling |
| GO:0030168 | NAS:UniProtKB | P | platelet activation |
| GO:2000373 | IDA:UniProtKB | P | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity |
| GO:0010628 | IMP:UniProtKB | P | positive regulation of gene expression |
| GO:0045089 | IMP:UniProtKB | P | positive regulation of innate immune response |
| GO:0045944 | IDA:UniProtKB | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0060368 | ISS:UniProtKB | P | regulation of Fc receptor mediated stimulatory signaling pathway |
| GO:0033003 | ISS:UniProtKB | P | regulation of mast cell activation |
| GO:0035456 | IMP:UniProtKB | P | response to interferon-beta |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005552 | Scramblase |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15162-1; Sequence=Displayed; Name=2; IsoId=O15162-2; Sequence=VSP_055237, VSP_055238; Note=No experimental confirmation available.; |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Domain | The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. |
| Function | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. |
| Function | May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. |
| Induction | By phosphorylation by PKC. Induced by IFNB1/IFN-beta in response to a viral infection. |
| Interaction | Q9WMX2:- (xeno); NbExp=8; IntAct=EBI-740019, EBI-710918; Q16630:CPSF6; NbExp=2; IntAct=EBI-740019, EBI-358410; P09022:Hoxa1 (xeno); NbExp=3; IntAct=EBI-740019, EBI-3957603; Q8WWR8:NEU4; NbExp=2; IntAct=EBI-740019, EBI-746964; Q16625:OCLN; NbExp=2; IntAct=EBI-740019, EBI-2903088; Q92734:TFG; NbExp=2; IntAct=EBI-740019, EBI-357061; |
| Similarity | Belongs to the phospholipid scramblase family. |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus. |
| Subunit | Interacts with ABL. |
| Tissue Specificity | Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle. |
| Web Resource | Name=Wikipedia; Note=Scramblase entry; URL="http://en.wikipedia.org/wiki/Scramblase"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000381 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 10863877 | RefSeq | NP_066928 | 318 | phospholipid scramblase 1 |
Identical Sequences to LMP000381 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:10863877 | EMBL | CCF77041.1 | 318 | unnamed protein product [Homo sapiens] |
| GI:10863877 | GenBank | ADR96815.1 | 318 | Sequence 69 from patent US 7749695 |
| GI:10863877 | GenBank | ADR96826.1 | 318 | Sequence 92 from patent US 7749695 |
| GI:10863877 | GenBank | ADS30371.1 | 318 | Sequence 903 from patent US 7781168 |
| GI:10863877 | GenBank | AED39009.1 | 318 | Sequence 827 from patent US 7883858 |
| GI:10863877 | GenBank | AGU19063.1 | 318 | Sequence 12 from patent US 8519096 |
Related Sequences to LMP000381 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:10863877 | GenBank | AAE57627.1 | 422 | Sequence 4 from patent US 6172210 |
| GI:10863877 | GenBank | ACM85995.1 | 361 | Sequence 11493 from patent US 6812339 |
| GI:10863877 | GenBank | JAA02027.1 | 318 | phospholipid scramblase 1 [Pan troglodytes] |
| GI:10863877 | GenBank | JAA16213.1 | 318 | phospholipid scramblase 1 [Pan troglodytes] |
| GI:10863877 | GenBank | JAA29743.1 | 318 | phospholipid scramblase 1 [Pan troglodytes] |
| GI:10863877 | GenBank | JAA35325.1 | 318 | phospholipid scramblase 1 [Pan troglodytes] |