Gene/Proteome Database (LMPD)

LMPD ID
LMP000382
Gene ID
13105
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 2, subfamily d, polypeptide 9
Gene Symbol
Cyp2d9
Synonyms
Cyp2d; P450-2D
Alternate Names
cytochrome P450 2D9; CYPIID9; cytochrome P450CA; cytochrome P450, 2d9; cytochrome P450-16-alpha; testosterone 16alpha-hydroxylase; testosterone 16-alpha hydroxylase
Chromosome
15
Map Location
15 E1|15 38.6 cM
EC Number
1.14.14.1

Proteins

cytochrome P450 2D9
Refseq ID NP_034136
Protein GI 160948612
UniProt ID P11714
mRNA ID NM_010006
Length 504
RefSeq Status VALIDATED
MELLTGTDLWPVAIFTVIFILLVDLTHQRQRWTSRYPPGPVPWPVLGNLLQVDLGNMPYSLYKLQNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEANHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTEVSGLIPEVLNAFPILLRIPRLADKALQGQKSFIAILDNLLTENRTTWDPVQAPRNLTDAFLAEIEKAKGNPESSFNDENLLMVVRDLFGAGMLTTSTTLSWALMLMILHPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEALARMELFLFFTCLLQRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCAVVRDQGH

Gene Information

Entrez Gene ID
13105
Gene Name
cytochrome P450, family 2, subfamily d, polypeptide 9
Gene Symbol
Cyp2d9
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding

KEGG Pathway Links

KEGG Pathway ID Description
mmu04726 Serotonergic synapse
ko00140 Steroid hormone biosynthesis
mmu00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5892994 Xenobiotics

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily d, polypeptide 9
Protein Entry
CP2D9_MOUSE
UniProt ID
P11714
Species
Mouse

Comments

Comment Type Description
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Induction P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP000382 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160948612 RefSeq NP_034136 504 cytochrome P450 2D9

Identical Sequences to LMP000382 proteins

Reference Database Accession Length Protein Name
GI:160948612 GenBank AAH10593.1 504 Cytochrome P450, family 2, subfamily d, polypeptide 9 [Mus musculus]
GI:160948612 GenBank AAH94015.1 504 Cytochrome P450, family 2, subfamily d, polypeptide 9 [Mus musculus]
GI:160948612 GenBank EDL04501.1 504 mCG8136, isoform CRA_b [Mus musculus]
GI:160948612 SwissProt P11714.2 504 RecName: Full=Cytochrome P450 2D9; AltName: Full=CYPIID9; AltName: Full=Cytochrome P450-16-alpha; AltName: Full=Cytochrome P450CA; AltName: Full=Testosterone 16-alpha hydroxylase [Mus musculus]

Related Sequences to LMP000382 proteins

Reference Database Accession Length Protein Name
GI:160948612 DBBJ BAE25635.1 504 unnamed protein product [Mus musculus]
GI:160948612 GenBank AAA40427.1 504 testosterone 16-alpha-hydroxylase [Mus musculus]
GI:160948612 GenBank AAA75462.1 504 testosterone 16-alpha-hydroxylase [Mus musculus domesticus]
GI:160948612 GenBank AAA39876.1 504 cytochrome P450-16-alpha [Mus musculus domesticus]
GI:160948612 GenBank AAC52245.1 504 P45016a-ms1 [Mus spretus]
GI:160948612 GenBank AAC52246.1 504 P45016a-ms2 [Mus spretus]