Gene/Proteome Database (LMPD)

LMPD ID
LMP000404
Gene ID
55825
Species
Homo sapiens (Human)
Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Gene Symbol
PECR
Synonyms
DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1; TERP
Alternate Names
peroxisomal trans-2-enoyl-CoA reductase; DCR-RP; pVI-ARL; 2,4-dienoyl-CoA reductase-related protein; putative short chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 29C, member 1
Chromosome
2
Map Location
2q35
EC Number
1.3.1.38

Proteins

peroxisomal trans-2-enoyl-CoA reductase
Refseq ID NP_060911
Protein GI 19923817
UniProt ID Q9BY49
mRNA ID NM_018441
Length 303
RefSeq Status VALIDATED
MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEKAKL

Gene Information

Entrez Gene ID
55825
Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Gene Symbol
PECR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005778 ISS:UniProtKB C peroxisomal membrane
GO:0005777 IDA:UniProtKB C peroxisome
GO:0005102 IPI:UniProtKB F receptor binding
GO:0019166 IDA:UniProtKB F trans-2-enoyl-CoA reductase (NADPH) activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process
GO:0055114 IDA:UniProtKB P oxidation-reduction process
GO:0033306 IDA:UniProtKB P phytol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01040 Biosynthesis of unsaturated fatty acids
hsa01212 Fatty acid metabolism
hsa04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Protein Entry
PECR_HUMAN
UniProt ID
Q9BY49
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BY49-1; Sequence=Displayed; Name=2; IsoId=Q9BY49-2; Sequence=VSP_013260;
Catalytic Activity Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Function Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.
Induction Not induced by IR.
Pathway Lipid metabolism; fatty acid biosynthesis.
Sequence Caution Sequence=AAF69798.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular Location Peroxisome .
Subunit Interacts with PEX5, probably required to target it into peroxisomes.

Identical and Related Proteins

Unique RefSeq proteins for LMP000404 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19923817 RefSeq NP_060911 303 peroxisomal trans-2-enoyl-CoA reductase

Identical Sequences to LMP000404 proteins

Reference Database Accession Length Protein Name
GI:19923817 DBBJ BAG38139.1 303 unnamed protein product [Homo sapiens]
GI:19923817 DBBJ BAG73523.1 303 peroxisomal trans-2-enoyl-CoA reductase, partial [synthetic construct]
GI:19923817 GenBank AAY14657.1 303 unknown [Homo sapiens]
GI:19923817 GenBank ACE87059.1 303 peroxisomal trans-2-enoyl-CoA reductase protein, partial [synthetic construct]
GI:19923817 GenBank ACE87740.1 303 peroxisomal trans-2-enoyl-CoA reductase protein [synthetic construct]
GI:19923817 GenBank AIC56749.1 303 PECR [synthetic construct]

Related Sequences to LMP000404 proteins

Reference Database Accession Length Protein Name
GI:19923817 GenBank AAK14920.1 322 HPDHase [Homo sapiens]
GI:19923817 GenBank EAW70558.1 322 peroxisomal trans-2-enoyl-CoA reductase, isoform CRA_b [Homo sapiens]
GI:19923817 GenBank JAA05246.1 322 peroxisomal trans-2-enoyl-CoA reductase [Pan troglodytes]
GI:19923817 GenBank JAA05247.1 322 peroxisomal trans-2-enoyl-CoA reductase [Pan troglodytes]
GI:19923817 GenBank JAA05248.1 322 peroxisomal trans-2-enoyl-CoA reductase [Pan troglodytes]
GI:19923817 GenBank JAA05249.1 322 peroxisomal trans-2-enoyl-CoA reductase [Pan troglodytes]