Gene/Proteome Database (LMPD)

LMPD ID
LMP000408
Gene ID
3628
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate-1-phosphatase
Gene Symbol
INPP1
Synonyms
-
Alternate Names
inositol polyphosphate 1-phosphatase; IPP; IPPase
Chromosome
2
Map Location
2q32
EC Number
3.1.3.57
Summary
This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for INPP1

Proteins

inositol polyphosphate 1-phosphatase
Refseq ID NP_001122400
Protein GI 193083155
UniProt ID P49441
mRNA ID NM_001128928
Length 399
RefSeq Status REVIEWED
MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEVIKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEETAELLSKVLNGNKVASEALARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQYIKGSADIKSNQGIFPCGLQCVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQCYWGLSYMGTNMHSLQLTISRRNGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAALSRVCGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDLKECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKRLETFLSLLVQNLAPAETHT
inositol polyphosphate 1-phosphatase
Refseq ID NP_002185
Protein GI 4504703
UniProt ID P49441
mRNA ID NM_002194
Length 399
RefSeq Status REVIEWED
Protein sequence is identical to GI:193083155 (mRNA isoform)

Gene Information

Entrez Gene ID
3628
Gene Name
inositol polyphosphate-1-phosphatase
Gene Symbol
INPP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0052829 TAS:Reactome F inositol-1,3,4-trisphosphate 1-phosphatase activity
GO:0004441 TAS:Reactome F inositol-1,4-bisphosphate 1-phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016311 TAS:GOC P dephosphorylation
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0006796 TAS:ProtInc P phosphate-containing compound metabolic process
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation
GO:0007165 TAS:ProtInc P signal transduction
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00562 Inositol phosphate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150352 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR000760 Inositol_monophosphatase
IPR020550 Inositol monophosphatase, conserved site
IPR020583 Inositol monophosphatase, metal-binding site

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-1-phosphatase
Protein Entry
INPP_HUMAN
UniProt ID
P49441
Species
Human

Comments

Comment Type Description
Catalytic Activity 1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D- myo-inositol 4-phosphate + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI
Enzyme Regulation Inhibited by Li(+).
Pathway Signal transduction; phosphatidylinositol signaling pathway.
Similarity Belongs to the inositol monophosphatase family.
Subunit Monomer.
Tissue Specificity Ubiquitously expressed, with highest levels in pancreas and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP000408 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
193083155 RefSeq NP_001122400 399 inositol polyphosphate 1-phosphatase

Identical Sequences to LMP000408 proteins

Reference Database Accession Length Protein Name
GI:193083155 GenBank ADF11519.1 399 Sequence 75 from patent US 7662917
GI:193083155 GenBank AFQ88420.1 399 Sequence 75 from patent US 8252903
GI:193083155 GenBank AHD69512.1 399 Sequence 526 from patent US 8586006
GI:193083155 GenBank AIC49066.1 399 INPP1, partial [synthetic construct]
GI:193083155 RefSeq XP_005246589.1 399 PREDICTED: inositol polyphosphate 1-phosphatase isoform X1 [Homo sapiens]
GI:193083155 RefSeq XP_006712561.1 399 PREDICTED: inositol polyphosphate 1-phosphatase isoform X2 [Homo sapiens]

Related Sequences to LMP000408 proteins

Reference Database Accession Length Protein Name
GI:193083155 RefSeq XP_003825324.1 399 PREDICTED: inositol polyphosphate 1-phosphatase [Pan paniscus]
GI:193083155 RefSeq XP_008948848.1 399 PREDICTED: inositol polyphosphate 1-phosphatase [Pan paniscus]
GI:193083155 RefSeq XP_008948849.1 399 PREDICTED: inositol polyphosphate 1-phosphatase [Pan paniscus]
GI:193083155 RefSeq XP_008948850.1 399 PREDICTED: inositol polyphosphate 1-phosphatase [Pan paniscus]
GI:193083155 RefSeq XP_008948852.1 399 PREDICTED: inositol polyphosphate 1-phosphatase [Pan paniscus]
GI:193083155 RefSeq XP_008948853.1 399 PREDICTED: inositol polyphosphate 1-phosphatase [Pan paniscus]