Gene/Proteome Database (LMPD)

LMPD ID
LMP000416
Gene ID
116519
Species
Homo sapiens (Human)
Gene Name
apolipoprotein A-V
Gene Symbol
APOA5
Synonyms
APOAV; RAP3
Alternate Names
apolipoprotein A-V; apo-AV; apolipoprotein A5; regeneration-associated protein 3
Chromosome
11
Map Location
11q23
Summary
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for APOA5

Proteins

apolipoprotein A-V precursor
Refseq ID NP_001160070
Protein GI 262231737
UniProt ID Q6Q788
mRNA ID NM_001166598
Length 366
RefSeq Status REVIEWED
MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP
apolipoprotein A-V precursor
Refseq ID NP_443200
Protein GI 63079709
UniProt ID Q6Q788
mRNA ID NM_052968
Length 366
RefSeq Status REVIEWED
Protein sequence is identical to GI:262231737 (mRNA isoform)
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2326 peptide sequence: MASMAAVLTWALALLSAFSATQA mat_peptide: 24..366 product: apolipoprotein A-V calculated_mol_wt: 38905 peptide sequence: RKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2326 peptide sequence: MASMAAVLTWALALLSAFSATQA mat_peptide: 24..366 product: apolipoprotein A-V calculated_mol_wt: 38905 peptide sequence: RKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP

Gene Information

Entrez Gene ID
116519
Gene Name
apolipoprotein A-V
Gene Symbol
APOA5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042627 IDA:UniProtKB C chylomicron
GO:0005576 IDA:UniProtKB C extracellular region
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0034364 IDA:BHF-UCL C high-density lipoprotein particle
GO:0034361 IDA:BHF-UCL C very-low-density lipoprotein particle
GO:0008047 IDA:BHF-UCL F enzyme activator activity
GO:0019899 IDA:BHF-UCL F enzyme binding
GO:0008201 IDA:BHF-UCL F heparin binding
GO:0060229 IMP:BHF-UCL F lipase activator activity
GO:0035473 IPI:BHF-UCL F lipase binding
GO:0008289 IDA:UniProtKB F lipid binding
GO:0060230 IDA:BHF-UCL F lipoprotein lipase activator activity
GO:0070325 IPI:BHF-UCL F lipoprotein particle receptor binding
GO:0050750 IPI:BHF-UCL F low-density lipoprotein particle receptor binding
GO:0031210 IDA:BHF-UCL F phosphatidylcholine binding
GO:0005543 IDA:BHF-UCL F phospholipid binding
GO:0055090 IDA:BHF-UCL P acylglycerol homeostasis
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0042632 IDA:BHF-UCL P cholesterol homeostasis
GO:0006869 IDA:BHF-UCL P lipid transport
GO:0042157 IEA:InterPro P lipoprotein metabolic process
GO:0031100 IEA:Ensembl P organ regeneration
GO:0045723 IDA:BHF-UCL P positive regulation of fatty acid biosynthetic process
GO:0050996 IDA:BHF-UCL P positive regulation of lipid catabolic process
GO:0051006 IDA:BHF-UCL P positive regulation of lipoprotein lipase activity
GO:0048260 TAS:BHF-UCL P positive regulation of receptor-mediated endocytosis
GO:0010898 IDA:BHF-UCL P positive regulation of triglyceride catabolic process
GO:0010902 IDA:BHF-UCL P positive regulation of very-low-density lipoprotein particle remodeling
GO:0009725 IEA:Ensembl P response to hormone
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0042246 IEP:UniProtKB P tissue regeneration
GO:0019433 IMP:BHF-UCL P triglyceride catabolic process
GO:0070328 IDA:BHF-UCL P triglyceride homeostasis
GO:0006641 IDA:BHF-UCL P triglyceride metabolic process
GO:0034370 IEA:Ensembl P triglyceride-rich lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
hsa03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_6841 Chylomicron-mediated lipid transport
REACT_116145 PPARA activates gene expression

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-V
Protein Entry
APOA5_HUMAN
UniProt ID
Q6Q788
Species
Human

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-4 is the initiator.
Disease Hyperlipoproteinemia 5 (HLPP5) [MIM
Disease Hypertriglyceridemia, familial (FHTR) [MIM
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO
Induction Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates).
Miscellaneous Induced in early phase of liver regeneration.
Polymorphism Three common alleles are known: allele APOA5*1, APOA5*2 and APOA5*3. The APOA5*2 haplotype, which consists of 3 non-coding SNPs, is present in approximately 16% of Caucasians and is associated with increased plasma triglyceride concentrations. APOA5*3 haplotype is defined by the rare Ser-19-Trp substitution. Together, the APOA5*2 and APOA5*3 haplotypes are found in 25 to 50% of African Americans, Hispanics, and Caucasians.
Ptm Phosphorylation sites are present in the extracellular medium.
Sequence Caution Sequence=AAF25661.1; Type=Erroneous initiation; Evidence= ; Sequence=AAF25662.1; Type=Erroneous initiation; Evidence= ; Sequence=AAQ89109.1; Type=Erroneous termination; Positions=275; Note=Translated as Gln.; Evidence= ;
Similarity Belongs to the apolipoprotein A1/A4/E family.
Subcellular Location Secreted .
Subunit Interacts with GPIHBP1.
Tissue Specificity Liver and plasma. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP000416 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
262231737 RefSeq NP_001160070 366 apolipoprotein A-V precursor

Identical Sequences to LMP000416 proteins

Reference Database Accession Length Protein Name
GI:262231737 GenBank ACG89855.1 366 Sequence 89 from patent US 7385034
GI:262231737 GenBank ACP56739.1 366 Sequence 868 from patent US 7482117
GI:262231737 GenBank ADA52908.1 366 Sequence 738 from patent US 7625699
GI:262231737 GenBank ADS30336.1 366 Sequence 868 from patent US 7781168
GI:262231737 GenBank AHE01109.1 366 Sequence 56025 from patent US 8586006
GI:262231737 RefSeq XP_006718824.1 366 PREDICTED: apolipoprotein A-V isoform X1 [Homo sapiens]

Related Sequences to LMP000416 proteins

Reference Database Accession Length Protein Name
GI:262231737 DBBJ BAF85428.1 366 unnamed protein product [Homo sapiens]
GI:262231737 GenBank AAF25661.1 363 apolipoprotein A5 [Homo sapiens]
GI:262231737 GenBank AAR40700.1 366 Sequence 212 from patent US 6605592
GI:262231737 GenBank ADA08339.1 363 Sequence 87 from patent US 7601802
GI:262231737 GenBank ADS30337.1 363 Sequence 869 from patent US 7781168
GI:262231737 GenBank AIC57580.1 366 APOA5, partial [synthetic construct]