Gene/Proteome Database (LMPD)
LMPD ID
LMP000420
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Gene Symbol
Synonyms
-
Alternate Names
phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1 alpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
Chromosome
1
Map Location
1q21.3
EC Number
2.7.1.68
Proteins
| phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1 | |
|---|---|
| Refseq ID | NP_001129110 |
| Protein GI | 208431778 |
| UniProt ID | Q99755 |
| mRNA ID | NM_001135638 |
| Length | 562 |
| RefSeq Status | VALIDATED |
| MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH | |
| phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2 | |
|---|---|
| Refseq ID | NP_003548 |
| Protein GI | 4505815 |
| UniProt ID | Q99755 |
| mRNA ID | NM_003557 |
| Length | 549 |
| RefSeq Status | VALIDATED |
| MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH | |
| phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3 | |
|---|---|
| Refseq ID | NP_001129108 |
| Protein GI | 208431774 |
| UniProt ID | Q99755 |
| mRNA ID | NM_001135636 |
| Length | 522 |
| RefSeq Status | VALIDATED |
| MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDQFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH | |
| phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4 | |
|---|---|
| Refseq ID | NP_001129109 |
| Protein GI | 208431776 |
| UniProt ID | Q99755 |
| mRNA ID | NM_001135637 |
| Length | 500 |
| RefSeq Status | VALIDATED |
| MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPCVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005925 | IDA:UniProtKB | C | focal adhesion |
| GO:0030027 | IDA:UniProtKB | C | lamellipodium |
| GO:0016607 | IDA:UniProtKB | C | nuclear speck |
| GO:0005634 | IDA:UniProtKB | C | nucleus |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0032587 | IDA:UniProtKB | C | ruffle membrane |
| GO:0016308 | IDA:UniProtKB | F | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0019900 | IDA:UniProtKB | F | kinase binding |
| GO:0031532 | IMP:UniProtKB | P | actin cytoskeleton reorganization |
| GO:0032863 | IMP:UniProtKB | P | activation of Rac GTPase activity |
| GO:0060326 | IMP:UniProtKB | P | cell chemotaxis |
| GO:0016477 | NAS:UniProtKB | P | cell migration |
| GO:0010761 | IEA:Ensembl | P | fibroblast migration |
| GO:0048041 | IMP:UniProtKB | P | focal adhesion assembly |
| GO:0006650 | TAS:ProtInc | P | glycerophospholipid metabolic process |
| GO:0030216 | TAS:UniProtKB | P | keratinocyte differentiation |
| GO:0006909 | TAS:UniProtKB | P | phagocytosis |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0046854 | IDA:GOC | P | phosphatidylinositol phosphorylation |
| GO:0008654 | IDA:UniProtKB | P | phospholipid biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0072661 | IMP:UniProtKB | P | protein targeting to plasma membrane |
| GO:0097178 | IMP:UniProtKB | P | ruffle assembly |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR023610 | Phosphatidylinositol-4-phosphate 5-kinase |
| IPR027483 | Phosphatidylinositol-4-phosphate 5-kinase, C-terminal |
| IPR027484 | Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain |
| IPR002498 | Phosphatidylinositol-4-phosphate 5-kinase, core |
| IPR016034 | Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Protein Entry
PI51A_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PIP5KIalpha2; IsoId=Q99755-1; Sequence=Displayed; Name=2; Synonyms=PIP5KIalpha3; IsoId=Q99755-2; Sequence=VSP_016007, VSP_016008; Name=3; IsoId=Q99755-3; Sequence=VSP_016007; Name=4; IsoId=Q99755-4; Sequence=VSP_041912, VSP_041913; |
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| Caution | There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha. |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. {ECO |
| Similarity | Contains 1 PIPK domain. {ECO |
| Subcellular Location | Cell membrane. Cytoplasm . Nucleus speckle. Cell projection, ruffle. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs. |
| Subunit | Interacts with RAC1 (By similarity). Interacts with TUT1. Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation. {ECO |
| Tissue Specificity | Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000420 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 208431778 | RefSeq | NP_001129110 | 562 | phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1 |
| 4505815 | RefSeq | NP_003548 | 549 | phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2 |
| 208431774 | RefSeq | NP_001129108 | 522 | phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3 |
| 208431776 | RefSeq | NP_001129109 | 500 | phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4 |
Identical Sequences to LMP000420 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505815 | DBBJ | BAF83704.1 | 549 | unnamed protein product [Homo sapiens] |
| GI:4505815 | EMBL | CAF02374.1 | 549 | unnamed protein product [Homo sapiens] |
| GI:208431776 | EMBL | CAF02375.1 | 500 | unnamed protein product [Homo sapiens] |
| GI:208431778 | EMBL | CAF02376.1 | 562 | unnamed protein product [Homo sapiens] |
| GI:208431778 | GenBank | AAC50911.1 | 562 | 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha [Homo sapiens] |
| GI:208431776 | GenBank | AAC50912.1 | 500 | 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha [Homo sapiens] |
| GI:208431776 | GenBank | AAH07833.1 | 500 | PIP5K1A protein [Homo sapiens] |
| GI:208431778 | GenBank | EAW53459.1 | 562 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, isoform CRA_a [Homo sapiens] |
| GI:208431776 | GenBank | EAW53460.1 | 500 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, isoform CRA_b [Homo sapiens] |
| GI:4505815 | GenBank | EAW53461.1 | 549 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, isoform CRA_c [Homo sapiens] |
| GI:4505815 | GenBank | ACM80886.1 | 549 | Sequence 6384 from patent US 6812339 |
| GI:4505815 | GenBank | AEP61113.1 | 549 | Sequence 107 from patent US 8026065 |
| GI:4505815 | GenBank | AFA57511.1 | 549 | Sequence 6 from patent US 8088574 |
| GI:208431776 | GenBank | AIC55403.1 | 500 | PIP5K1A, partial [synthetic construct] |
| GI:208431776 | GenBank | AIC62629.1 | 500 | PIP5K1A, partial [synthetic construct] |
| GI:208431778 | SwissProt | Q99755.1 | 562 | RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Short=PIP5K1-alpha; Short=PtdIns(4)P-5-kinase 1 alpha; AltName: Full=68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Short=PIP5KIalpha [Homo sapiens] |
Related Sequences to LMP000420 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:208431776 | GenBank | AAQ02397.1 | 501 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, partial [synthetic construct] |
| GI:208431776 | GenBank | JAA17019.1 | 500 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [Pan troglodytes] |
| GI:208431776 | GenBank | JAA32441.1 | 500 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [Pan troglodytes] |
| GI:208431776 | GenBank | JAA41134.1 | 500 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [Pan troglodytes] |
| GI:4505815 | RefSeq | NP_001131030.1 | 550 | phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [Pan troglodytes] |
| GI:208431778 | RefSeq | XP_005245582.1 | 572 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [Homo sapiens] |
| GI:208431778 | RefSeq | XP_005245583.1 | 571 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [Homo sapiens] |
| GI:208431778 | RefSeq | XP_005245584.1 | 561 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [Homo sapiens] |
| GI:4505815 | RefSeq | XP_005245585.1 | 560 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [Homo sapiens] |
| GI:4505815 | RefSeq | XP_005245586.1 | 559 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5 [Homo sapiens] |
| GI:208431778 | RefSeq | XP_005541968.1 | 592 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [Macaca fascicularis] |
| GI:4505815 | RefSeq | XP_005541970.1 | 579 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6 [Macaca fascicularis] |
| GI:208431778 | RefSeq | XP_005541971.1 | 562 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7 [Macaca fascicularis] |
| GI:208431774 | RefSeq | XP_005541974.1 | 552 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10 [Macaca fascicularis] |
| GI:208431776 | RefSeq | XP_005541975.1 | 530 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11 [Macaca fascicularis] |
| GI:4505815 | RefSeq | XP_007975426.1 | 579 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8 [Chlorocebus sabaeus] |
| GI:208431774 | RefSeq | XP_007975429.1 | 565 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11 [Chlorocebus sabaeus] |
| GI:208431778 | RefSeq | XP_007975430.1 | 562 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X12 [Chlorocebus sabaeus] |
| GI:208431774 | RefSeq | XP_007975431.1 | 552 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X13 [Chlorocebus sabaeus] |
| GI:208431774 | RefSeq | XP_007975441.1 | 522 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X17 [Chlorocebus sabaeus] |
| GI:4505815 | RefSeq | XP_008968669.1 | 550 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [Pan paniscus] |
| GI:208431776 | RefSeq | XP_009428659.1 | 500 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5 [Pan troglodytes] |
| GI:208431774 | RefSeq | XP_010385506.1 | 534 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7 [Rhinopithecus roxellana] |
| GI:208431774 | RefSeq | XP_010385507.1 | 522 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8 [Rhinopithecus roxellana] |