Gene/Proteome Database (LMPD)

LMPD ID
LMP000428
Gene ID
20249
Species
Mus musculus (Mouse)
Gene Name
stearoyl-Coenzyme A desaturase 1
Gene Symbol
Scd1
Synonyms
AA589638; AI265570; Scd; Scd-1; ab
Alternate Names
acyl-CoA desaturase 1; asebia; delta-9 desaturase 1; delta(9)-desaturase 1; fatty acid desaturase 1; stearoyl-CoA desaturase 1
Chromosome
19
Map Location
19 C3|19 37.98 cM
EC Number
1.14.19.1

Proteins

acyl-CoA desaturase 1
Refseq ID NP_033153
Protein GI 31543675
UniProt ID P13516
mRNA ID NM_009127
Length 355
RefSeq Status VALIDATED
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS

Gene Information

Entrez Gene ID
20249
Gene Name
stearoyl-Coenzyme A desaturase 1
Gene Symbol
Scd1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 IDA:WormBase C integral component of endoplasmic reticulum membrane
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IEA:UniProtKB-EC F stearoyl-CoA 9-desaturase activity
GO:0050873 IDA:MGI P brown fat cell differentiation
GO:0034435 IMP:MGI P cholesterol esterification
GO:0050830 IMP:MGI P defense response to Gram-positive bacterium
GO:0006633 IMP:MGI P fatty acid biosynthetic process
GO:0044130 IMP:MGI P negative regulation of growth of symbiont in host
GO:0010873 TAS:BHF-UCL P positive regulation of cholesterol esterification
GO:0050872 IDA:MGI P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
mmu04152 AMPK signaling pathway
mmu03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR015876 Fatty acid desaturase, type 1, core
IPR001522 Fatty acid desaturase, type 1, C-terminal

UniProt Annotations

Entry Information

Gene Name
stearoyl-Coenzyme A desaturase 1
Protein Entry
ACOD1_MOUSE
UniProt ID
P13516
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16275639}; Multi-pass membrane protein {ECO:0000269|PubMed:16275639}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000428 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31543675 RefSeq NP_033153 355 acyl-CoA desaturase 1

Identical Sequences to LMP000428 proteins

Reference Database Accession Length Protein Name
GI:31543675 DBBJ BAE28345.1 355 unnamed protein product [Mus musculus]
GI:31543675 DBBJ BAE25137.1 355 unnamed protein product [Mus musculus]
GI:31543675 EMBL CAJ18379.1 355 Scd1 [Mus musculus]
GI:31543675 EMBL CAJ18540.1 355 Scd1 [Mus musculus]
GI:31543675 GenBank AAH55453.1 355 Stearoyl-Coenzyme A desaturase 1 [Mus musculus]
GI:31543675 GenBank EDL41930.1 355 mCG131749 [Mus musculus]

Related Sequences to LMP000428 proteins

Reference Database Accession Length Protein Name
GI:31543675 GenBank AAA40103.1 355 stearoyl-CoA desaturase [Mus musculus]
GI:31543675 GenBank AAM34745.1 358 stearoyl-coenzyme A desaturase 1 [Rattus norvegicus]
GI:31543675 GenBank AAM34746.1 358 stearoyl-coenzyme A desaturase 1 [Rattus norvegicus]
GI:31543675 GenBank EDL94283.1 358 rCG57790, isoform CRA_a [Rattus norvegicus]
GI:31543675 GenBank ABU29329.1 355 Sequence 3 from patent US 7232662
GI:31543675 GenBank ACK08921.1 355 Sequence 3 from patent US 7435559