Gene/Proteome Database (LMPD)

LMPD ID
LMP000431
Gene ID
23780
Species
Homo sapiens (Human)
Gene Name
apolipoprotein L, 2
Gene Symbol
APOL2
Synonyms
APOL-II; APOL3
Alternate Names
apolipoprotein L2; apolipoprotein L-II
Chromosome
22
Map Location
22q12
Summary
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for APOL2

Proteins

apolipoprotein L2
Refseq ID NP_112092
Protein GI 13562090
UniProt ID Q9BQE5
mRNA ID NM_030882
Length 337
RefSeq Status REVIEWED
MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHIIGRISAEGGEQVERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ
apolipoprotein L2
Refseq ID NP_663612
Protein GI 22035653
UniProt ID Q9BQE5
mRNA ID NM_145637
Length 337
RefSeq Status REVIEWED
Protein sequence is identical to GI:13562090 (mRNA isoform)

Gene Information

Entrez Gene ID
23780
Gene Name
apolipoprotein L, 2
Gene Symbol
APOL2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 NAS:UniProtKB C endoplasmic reticulum membrane
GO:0005576 IEA:InterPro C extracellular region
GO:0016020 IDA:UniProtKB C membrane
GO:0008035 NAS:UniProtKB F high-density lipoprotein particle binding
GO:0008289 NAS:UniProtKB F lipid binding
GO:0005102 NAS:UniProtKB F receptor binding
GO:0006953 NAS:UniProtKB P acute-phase response
GO:0008203 NAS:UniProtKB P cholesterol metabolic process
GO:0006629 NAS:UniProtKB P lipid metabolic process
GO:0006869 NAS:UniProtKB P lipid transport
GO:0042157 IEA:InterPro P lipoprotein metabolic process
GO:0060135 NAS:UniProtKB P maternal process involved in female pregnancy
GO:0007275 NAS:UniProtKB P multicellular organismal development

Domain Information

InterPro Annotations

Accession Description
IPR008405 Apolipoprotein L

UniProt Annotations

Entry Information

Gene Name
apolipoprotein L, 2
Protein Entry
APOL2_HUMAN
UniProt ID
Q9BQE5
Species
Human

Comments

Comment Type Description
Function May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Sequence Caution Sequence=BAD92227.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the apolipoprotein L family.
Subcellular Location Cytoplasm .
Tissue Specificity Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP000431 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13562090 RefSeq NP_112092 337 apolipoprotein L2

Identical Sequences to LMP000431 proteins

Reference Database Accession Length Protein Name
GI:13562090 GenBank AAK11593.1 337 apolipoprotein L-II [Homo sapiens]
GI:13562090 GenBank AAK11598.1 337 apolipoprotein L-II [Homo sapiens]
GI:13562090 GenBank AAK20211.1 337 apolipoprotein L2 [Homo sapiens]
GI:13562090 GenBank ACE10317.1 337 Sequence 4 from patent US 7361511
GI:13562090 RefSeq NP_663612.1 337 apolipoprotein L2 [Homo sapiens]
GI:13562090 SwissProt Q9BQE5.1 337 RecName: Full=Apolipoprotein L2; AltName: Full=Apolipoprotein L-II; Short=ApoL-II [Homo sapiens]

Related Sequences to LMP000431 proteins

Reference Database Accession Length Protein Name
GI:13562090 GenBank EAW60087.1 337 apolipoprotein L, 2, isoform CRA_a [Homo sapiens]
GI:13562090 GenBank ADT42353.1 337 Sequence 1299 from patent US 7833706
GI:13562090 GenBank ADT42354.1 337 Sequence 1300 from patent US 7833706
GI:13562090 GenBank ADT42355.1 337 Sequence 1301 from patent US 7833706
GI:13562090 RefSeq NP_112092.2 337 apolipoprotein L2 [Homo sapiens]
GI:13562090 RefSeq NP_663612.2 337 apolipoprotein L2 [Homo sapiens]