Gene/Proteome Database (LMPD)

LMPD ID
LMP000437
Gene ID
11687
Species
Mus musculus (Mouse)
Gene Name
arachidonate 15-lipoxygenase
Gene Symbol
Alox15
Synonyms
12-LO; 12/15-LO; 15-LOX; Alox12l; L-12LO
Chromosome
11
Map Location
11 B3|11 42.99 cM

Proteins

arachidonate 15-lipoxygenase
Refseq ID NP_033790
Protein GI 134948633
UniProt ID P39654
mRNA ID NM_009660
Length 663
RefSeq Status VALIDATED
MGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI

Gene Information

Entrez Gene ID
11687
Gene Name
arachidonate 15-lipoxygenase
Gene Symbol
Alox15
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0031234 IEA:Ensembl C extrinsic component of cytoplasmic side of plasma membrane
GO:0005811 IEA:Ensembl C lipid particle
GO:0004052 IEA:Ensembl F arachidonate 12-lipoxygenase activity
GO:0050473 IEA:Ensembl F arachidonate 15-lipoxygenase activity
GO:0051120 IEA:Ensembl F hepoxilin A3 synthase activity
GO:0047977 IEA:Ensembl F hepoxilin-epoxide hydrolase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0005546 IEA:Ensembl F phosphatidylinositol-4,5-bisphosphate binding
GO:0019369 IEA:Ensembl P arachidonic acid metabolic process
GO:0030282 IMP:MGI P bone mineralization
GO:0071277 IEA:Ensembl P cellular response to calcium ion
GO:0035963 IEA:Ensembl P cellular response to interleukin-13
GO:0051122 IEA:Ensembl P hepoxilin biosynthetic process
GO:0019372 IEA:Ensembl P lipoxygenase pathway
GO:0001503 IMP:MGI P ossification
GO:0070374 IEA:Ensembl P positive regulation of ERK1 and ERK2 cascade
GO:0010811 IEA:Ensembl P positive regulation of cell-substrate adhesion
GO:0034116 IEA:Ensembl P positive regulation of heterotypic cell-cell adhesion

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR020833 Lipoxygenase, iron binding site
IPR001885 Lipoxygenase, mammalian
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
arachidonate 15-lipoxygenase
Protein Entry
LOX15_MOUSE
UniProt ID
P39654
Species
Mouse

Comments

Comment Type Description
Cofactor Note=Iron. ;
Similarity Belongs to the lipoxygenase family.
Similarity Contains PLAT domain.
Similarity Contains lipoxygenase domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000437 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
134948633 RefSeq NP_033790 663 arachidonate 15-lipoxygenase

Identical Sequences to LMP000437 proteins

Reference Database Accession Length Protein Name
GI:134948633 DBBJ BAE25045.1 663 unnamed protein product [Mus musculus]
GI:134948633 GenBank AAA20658.1 663 leukocyte-type 12-lipoxygenase [Mus musculus]
GI:134948633 GenBank EDL12554.1 663 arachidonate 15-lipoxygenase [Mus musculus]
GI:134948633 GenBank ABV02575.1 663 arachidonate 15-lipoxygenase [Mus musculus]
GI:134948633 SwissProt P39654.4 663 RecName: Full=Arachidonate 15-lipoxygenase; Short=15-LOX; AltName: Full=12/15-lipoxygenase; Short=12/15-LO; AltName: Full=Arachidonate 12-lipoxygenase, leukocyte-type; Short=12-LOX; Short=L-12LO; AltName: Full=Arachidonate omega-6 lipoxygenase [Mus musculus]

Related Sequences to LMP000437 proteins

Reference Database Accession Length Protein Name
GI:134948633 EMBL CAJ18471.1 663 Alox15 [Mus musculus]
GI:134948633 GenBank AAA64930.1 663 12-lipoxygenase [Mus musculus]
GI:134948633 GenBank AAH56625.1 663 Alox15 protein [Mus musculus]
GI:134948633 GenBank AAH81546.1 663 Alox15 protein [Mus musculus]
GI:134948633 RefSeq XP_006532099.1 693 PREDICTED: arachidonate 15-lipoxygenase isoform X1 [Mus musculus]
GI:134948633 RefSeq XP_006537177.1 693 PREDICTED: arachidonate 15-lipoxygenase isoform X1 [Mus musculus]