Gene/Proteome Database (LMPD)

LMPD ID
LMP000445
Gene ID
1909
Species
Homo sapiens (Human)
Gene Name
endothelin receptor type A
Gene Symbol
EDNRA
Synonyms
ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR
Alternate Names
endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor
Chromosome
4
Map Location
4q31.22
Summary
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for EDNRA

Proteins

endothelin-1 receptor isoform a precursor
Refseq ID NP_001948
Protein GI 4503465
UniProt ID P25101
mRNA ID NM_001957
Length 427
RefSeq Status REVIEWED
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2213 peptide sequence: METLCLRASFWLALVGCVIS mat_peptide: 21..318 product: endothelin-1 receptor isoform b calculated_mol_wt: 34294 peptide sequence: DNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2213 peptide sequence: METLCLRASFWLALVGCVIS mat_peptide: 21..427 product: endothelin-1 receptor isoform a calculated_mol_wt: 46528 peptide sequence: DNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
endothelin-1 receptor isoform b precursor
Refseq ID NP_001159527
Protein GI 260593650
UniProt ID P25101
mRNA ID NM_001166055
Length 318
RefSeq Status REVIEWED
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
endothelin-1 receptor isoform c
Refseq ID NP_001243212
Protein GI 372266194
UniProt ID P25101
mRNA ID NM_001256283
Length 202
RefSeq Status REVIEWED
MVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN

Gene Information

Entrez Gene ID
1909
Gene Name
endothelin receptor type A
Gene Symbol
EDNRA
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030315 IEA:Ensembl C T-tubule
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0031965 IEA:Ensembl C nuclear membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0004962 NAS:UniProtKB F endothelin receptor activity
GO:0004435 TAS:ProtInc F phosphatidylinositol phospholipase C activity
GO:0007186 NAS:UniProtKB P G-protein coupled receptor signaling pathway
GO:0007266 IEA:Ensembl P Rho protein signal transduction
GO:0007190 TAS:ProtInc P activation of adenylate cyclase activity
GO:0007202 TAS:ProtInc P activation of phospholipase C activity
GO:0007568 IEA:Ensembl P aging
GO:0014824 IMP:BHF-UCL P artery smooth muscle contraction
GO:0008283 NAS:UniProtKB P cell proliferation
GO:0071260 IEA:Ensembl P cellular response to mechanical stimulus
GO:0086100 NAS:GOC P endothelin receptor signaling pathway
GO:0048484 IEA:InterPro P enteric nervous system development
GO:0048144 IEA:Ensembl P fibroblast proliferation
GO:0003094 IEA:Ensembl P glomerular filtration
GO:0015758 ISS:UniProtKB P glucose transport
GO:0060322 IEA:Ensembl P head development
GO:0007507 IEA:Ensembl P heart development
GO:0001821 IEA:Ensembl P histamine secretion
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0060137 IEA:Ensembl P maternal process involved in parturition
GO:0008152 TAS:GOC P metabolic process
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0030818 IEA:Ensembl P negative regulation of cAMP biosynthetic process
GO:0014032 IEA:Ensembl P neural crest cell development
GO:0001569 IEA:Ensembl P patterning of blood vessels
GO:0043084 IEA:Ensembl P penile erection
GO:0070374 IEA:Ensembl P positive regulation of ERK1 and ERK2 cascade
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0007204 TAS:ProtInc P positive regulation of cytosolic calcium ion concentration
GO:0051482 IEA:Ensembl P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0050729 IEA:Ensembl P positive regulation of inflammatory response
GO:0090184 IEA:Ensembl P positive regulation of kidney development
GO:0090023 IEA:Ensembl P positive regulation of neutrophil chemotaxis
GO:0042482 IEA:Ensembl P positive regulation of odontogenesis
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0051281 IEA:Ensembl P positive regulation of release of sequestered calcium ion into cytosol
GO:0007205 IEA:Ensembl P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008217 IEA:InterPro P regulation of blood pressure
GO:0050678 IEA:Ensembl P regulation of epithelial cell proliferation
GO:0007585 ISS:UniProtKB P respiratory gaseous exchange
GO:0001666 IEA:Ensembl P response to hypoxia
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0043278 IEA:Ensembl P response to morphine
GO:0019233 IEA:Ensembl P sensory perception of pain
GO:0007165 TAS:ProtInc P signal transduction
GO:0048659 IEA:Ensembl P smooth muscle cell proliferation
GO:0006939 NAS:UniProtKB P smooth muscle contraction
GO:0042310 IMP:BHF-UCL P vasoconstriction

KEGG Pathway Links

KEGG Pathway ID Description
hsa04020 Calcium signaling pathway
hsa04270 Vascular smooth muscle contraction
hsa04024 cAMP signaling pathway
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR002175 Endothelin receptor A
IPR000499 Endothelin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
endothelin receptor type A
Protein Entry
EDNRA_HUMAN
UniProt ID
P25101
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P25101-1; Sequence=Displayed; Name=2; Synonyms=Delta-3; IsoId=P25101-2; Sequence=VSP_011059, VSP_011060; Name=3; Synonyms=Delta-4; IsoId=P25101-3; Sequence=VSP_011062, VSP_011063; Name=4; Synonyms=Delta-3,4; IsoId=P25101-4; Sequence=VSP_011061; Name=5; IsoId=P25101-5; Sequence=VSP_045578; Note=No experimental confirmation available.;
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Interaction P05305:EDN1; NbExp=2; IntAct=EBI-6624559, EBI-715181;
Similarity Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with HDAC7 and KAT5.
Tissue Specificity Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ednra/";

Identical and Related Proteins

Unique RefSeq proteins for LMP000445 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4503465 RefSeq NP_001948 427 endothelin-1 receptor isoform a precursor
260593650 RefSeq NP_001159527 318 endothelin-1 receptor isoform b precursor
372266194 RefSeq NP_001243212 202 endothelin-1 receptor isoform c

Identical Sequences to LMP000445 proteins

Reference Database Accession Length Protein Name
GI:4503465 DBBJ BAI45765.1 427 endothelin receptor type A, partial [synthetic construct]
GI:260593650 GenBank AAB36327.1 318 endothelin-A receptor delta 3-4 [Homo sapiens]
GI:260593650 GenBank AAP00790.1 318 Sequence 9 from patent US 6518404
GI:260593650 GenBank EAX05018.1 318 endothelin receptor type A, isoform CRA_b [Homo sapiens]
GI:4503465 GenBank JAA06616.1 427 endothelin receptor type A [Pan troglodytes]
GI:4503465 GenBank JAA12707.1 427 endothelin receptor type A [Pan troglodytes]
GI:4503465 GenBank JAA30391.1 427 endothelin receptor type A [Pan troglodytes]
GI:4503465 GenBank JAA37808.1 427 endothelin receptor type A [Pan troglodytes]
GI:4503465 GenBank AHD74529.1 427 Sequence 14546 from patent US 8586006
GI:372266194 RefSeq XP_004040516.1 202 PREDICTED: endothelin-1 receptor [Gorilla gorilla gorilla]
GI:372266194 RefSeq XP_009205934.1 202 PREDICTED: endothelin-1 receptor isoform X2 [Papio anubis]

Related Sequences to LMP000445 proteins

Reference Database Accession Length Protein Name
GI:372266194 GenBank AAB23644.1 427 endothelin receptor subtype A [Homo sapiens]
GI:4503465 GenBank AAB25530.2 427 endothelin ET-A receptor [Homo sapiens]
GI:372266194 GenBank AAP32294.1 427 endothelin receptor type A [Homo sapiens]
GI:372266194 GenBank AAQ87880.1 427 endothelin receptor type A [Homo sapiens]
GI:4503465 GenBank AAW10815.1 427 Sequence 495 from patent US 6806054
GI:4503465 GenBank ABJ30527.1 427 Sequence 495 from patent US 7097969
GI:4503465 GenBank ACE50259.1 427 Sequence 495 from patent US 7381522
GI:372266194 GenBank ACK26111.1 427 Sequence 3 from patent US 7452970
GI:372266194 GenBank JAA06616.1 427 endothelin receptor type A [Pan troglodytes]
GI:372266194 RefSeq NP_001948.1 427 endothelin-1 receptor isoform a precursor [Homo sapiens]
GI:260593650 RefSeq XP_003257833.1 318 PREDICTED: endothelin-1 receptor isoform 2 [Nomascus leucogenys]
GI:4503465 RefSeq XP_004040514.1 427 PREDICTED: endothelin-1 receptor [Gorilla gorilla gorilla]
GI:260593650 RefSeq XP_004040515.1 318 PREDICTED: endothelin-1 receptor [Gorilla gorilla gorilla]
GI:260593650 RefSeq XP_004643677.1 318 PREDICTED: endothelin-1 receptor isoform X2 [Octodon degus]
GI:260593650 RefSeq XP_005556091.1 318 PREDICTED: endothelin-1 receptor isoform X2 [Macaca fascicularis]
GI:260593650 RefSeq XP_008063241.1 318 PREDICTED: endothelin-1 receptor isoform X2 [Tarsius syrichta]
GI:260593650 RefSeq XP_008142169.1 318 PREDICTED: endothelin-1 receptor isoform X2 [Eptesicus fuscus]
GI:4503465 RefSeq XP_008967127.1 427 PREDICTED: endothelin-1 receptor [Pan paniscus]