Gene/Proteome Database (LMPD)

LMPD ID
LMP000446
Gene ID
2180
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase long-chain family member 1
Gene Symbol
ACSL1
Synonyms
ACS1; FACL1; FACL2; LACS; LACS1; LACS2
Chromosome
4
Map Location
4q35.1
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Orthologs
View orthologs and multiple alignments for ACSL1

Proteins

long-chain-fatty-acid--CoA ligase 1 isoform a
Refseq ID NP_001986
Protein GI 40807491
UniProt ID P33121
mRNA ID NM_001995
Length 698
RefSeq Status REVIEWED
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
long-chain-fatty-acid--CoA ligase 1 isoform a
Refseq ID NP_001273637
Protein GI 557878736
UniProt ID P33121
mRNA ID NM_001286708
Length 698
RefSeq Status REVIEWED
Protein sequence is identical to GI:40807491 (mRNA isoform)
long-chain-fatty-acid--CoA ligase 1 isoform b
Refseq ID NP_001273639
Protein GI 557878738
UniProt ID P33121
mRNA ID NM_001286710
Length 698
RefSeq Status REVIEWED
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATEKALPLSASDTHISYLPLAHIYEQLLKCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
long-chain-fatty-acid--CoA ligase 1 isoform c
Refseq ID NP_001273640
Protein GI 557878738
UniProt ID P33121
mRNA ID NM_001286711
Length 698
RefSeq Status REVIEWED
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATEKALPLSASDTHISYLPLAHIYEQLLKCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
long-chain-fatty-acid--CoA ligase 1 isoform d
Refseq ID NP_001273641
Protein GI 557878742
UniProt ID P33121
mRNA ID NM_001286712
Length 527
RefSeq Status REVIEWED
MVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV

Gene Information

Entrez Gene ID
2180
Gene Name
acyl-CoA synthetase long-chain family member 1
Gene Symbol
ACSL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0003824 IEA:InterPro F catalytic activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
hsa03320 PPAR signaling pathway
hsa04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-387 fatty acid alpha-oxidation II

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase long-chain family member 1
Protein Entry
ACSL1_HUMAN
UniProt ID
P33121
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP000446 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40807491 RefSeq NP_001986 698 long-chain-fatty-acid--CoA ligase 1 isoform a
557878738 RefSeq NP_001273639 698 long-chain-fatty-acid--CoA ligase 1 isoform b
557878738 RefSeq NP_001273640 698 long-chain-fatty-acid--CoA ligase 1 isoform c
557878742 RefSeq NP_001273641 527 long-chain-fatty-acid--CoA ligase 1 isoform d

Identical Sequences to LMP000446 proteins

Reference Database Accession Length Protein Name
GI:557878742 DBBJ BAH12385.1 527 unnamed protein product [Homo sapiens]
GI:557878738 DBBJ BAH12438.1 698 unnamed protein product [Homo sapiens]
GI:557878738 DBBJ BAH12438.1 698 unnamed protein product [Homo sapiens]
GI:557878738 GenBank ADA06553.1 698 Sequence 78 from patent US 7601505
GI:557878738 GenBank ADA06553.1 698 Sequence 78 from patent US 7601505
GI:40807491 GenBank AGX56849.1 698 Sequence 14017 from patent US 8541208
GI:40807491 GenBank AHD78292.1 698 Sequence 26290 from patent US 8586006
GI:40807491 RefSeq XP_005262885.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X2 [Homo sapiens]
GI:40807491 RefSeq XP_005262886.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X3 [Homo sapiens]
GI:40807491 RefSeq XP_005262888.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X5 [Homo sapiens]
GI:40807491 RefSeq NP_001273637.1 698 long-chain-fatty-acid--CoA ligase 1 isoform a [Homo sapiens]

Related Sequences to LMP000446 proteins

Reference Database Accession Length Protein Name
GI:40807491 DBBJ BAF85487.1 698 unnamed protein product [Homo sapiens]
GI:557878742 GenBank AAH26290.1 539 ACSL1 protein, partial [Homo sapiens]
GI:40807491 GenBank ACM85978.1 702 Sequence 11476 from patent US 6812339
GI:40807491 GenBank ACM85979.1 702 Sequence 11477 from patent US 6812339
GI:557878742 GenBank ADA06554.1 698 Sequence 80 from patent US 7601505
GI:557878738 GenBank ADA06554.1 698 Sequence 80 from patent US 7601505
GI:557878738 GenBank ADA06554.1 698 Sequence 80 from patent US 7601505
GI:557878738 GenBank ADA18365.1 698 Sequence 189 from patent US 7608413
GI:557878738 GenBank ADA18365.1 698 Sequence 189 from patent US 7608413
GI:557878742 GenBank ADA18365.1 698 Sequence 189 from patent US 7608413
GI:557878742 GenBank ADA18366.1 698 Sequence 190 from patent US 7608413
GI:557878742 GenBank ADA18367.1 698 Sequence 191 from patent US 7608413
GI:557878742 GenBank ADA18368.1 698 Sequence 192 from patent US 7608413
GI:557878738 RefSeq XP_003271521.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform 1 [Nomascus leucogenys]
GI:557878738 RefSeq XP_003271521.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform 1 [Nomascus leucogenys]
GI:557878738 RefSeq XP_004040739.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform 1 [Gorilla gorilla gorilla]
GI:557878738 RefSeq XP_004040739.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform 1 [Gorilla gorilla gorilla]
GI:40807491 RefSeq XP_004040740.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform 2 [Gorilla gorilla gorilla]
GI:40807491 RefSeq XP_004040741.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform 3 [Gorilla gorilla gorilla]
GI:40807491 RefSeq XP_005262884.1 741 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X1 [Homo sapiens]
GI:557878738 RefSeq XP_006714201.1 741 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X6 [Homo sapiens]
GI:557878738 RefSeq XP_006714201.1 741 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X6 [Homo sapiens]
GI:557878738 RefSeq XP_009446808.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X2 [Pan troglodytes]
GI:557878738 RefSeq XP_009446808.1 698 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X2 [Pan troglodytes]