Gene/Proteome Database (LMPD)

LMPD ID
LMP000448
Gene ID
5724
Species
Homo sapiens (Human)
Gene Name
platelet-activating factor receptor
Gene Symbol
PTAFR
Synonyms
PAFR
Chromosome
1
Map Location
1p35-p34.3
Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Orthologs
View orthologs and multiple alignments for PTAFR

Proteins

platelet-activating factor receptor
Refseq ID NP_001158193
Protein GI 257900488
UniProt ID P25105
mRNA ID NM_001164721
Length 342
RefSeq Status REVIEWED
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
platelet-activating factor receptor
Refseq ID NP_000943
Protein GI 4506241
UniProt ID P25105
mRNA ID NM_000952
Length 342
RefSeq Status REVIEWED
Protein sequence is identical to GI:257900488 (mRNA isoform)
platelet-activating factor receptor
Refseq ID NP_001158194
Protein GI 257900491
UniProt ID P25105
mRNA ID NM_001164722
Length 342
RefSeq Status REVIEWED
Protein sequence is identical to GI:257900488 (mRNA isoform)
platelet-activating factor receptor
Refseq ID NP_001158195
Protein GI 257900493
UniProt ID P25105
mRNA ID NM_001164723
Length 342
RefSeq Status REVIEWED
Protein sequence is identical to GI:257900488 (mRNA isoform)

Gene Information

Entrez Gene ID
5724
Gene Name
platelet-activating factor receptor
Gene Symbol
PTAFR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0004930 TAS:ProtInc F G-protein coupled receptor activity
GO:0001530 IEA:Ensembl F lipopolysaccharide binding
GO:0001875 IEA:Ensembl F lipopolysaccharide receptor activity
GO:0005543 IDA:UniProtKB F phospholipid binding
GO:0004992 IDA:UniProtKB F platelet activating factor receptor activity
GO:0007186 IMP:UniProtKB P G-protein coupled receptor signaling pathway
GO:0006935 TAS:ProtInc P chemotaxis
GO:0001816 IEA:Ensembl P cytokine production
GO:0019221 TAS:Reactome P cytokine-mediated signaling pathway
GO:0006955 TAS:ProtInc P immune response
GO:0006954 TAS:ProtInc P inflammatory response
GO:0032959 IEA:Ensembl P inositol trisphosphate biosynthetic process
GO:0060333 TAS:Reactome P interferon-gamma-mediated signaling pathway
GO:0048015 IDA:UniProtKB P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
hsa04020 Calcium signaling pathway
hsa05150 Staphylococcus aureus infection

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_75790 Cytokine Signaling in Immune system

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR002282 Platelet-activating factor receptor

UniProt Annotations

Entry Information

Gene Name
platelet-activating factor receptor
Protein Entry
PTAFR_HUMAN
UniProt ID
P25105
Species
Human

Comments

Comment Type Description
Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO
Induction By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane ; Multi-pass membrane protein .
Subunit Interacts with ARRB1.
Tissue Specificity Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP000448 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
257900488 RefSeq NP_001158193 342 platelet-activating factor receptor

Identical Sequences to LMP000448 proteins

Reference Database Accession Length Protein Name
GI:257900488 GenBank ACT64516.1 342 platelet-activating factor receptor protein, partial [synthetic construct]
GI:257900488 GenBank ADS27670.1 342 Sequence 7 from patent US 7781209
GI:257900488 GenBank AFL35834.1 342 Sequence 7 from patent US 8178346
GI:257900488 GenBank AIC49521.1 342 PTAFR, partial [synthetic construct]
GI:257900488 RefSeq NP_001158194.1 342 platelet-activating factor receptor [Homo sapiens]
GI:257900488 RefSeq NP_001158195.1 342 platelet-activating factor receptor [Homo sapiens]

Related Sequences to LMP000448 proteins

Reference Database Accession Length Protein Name
GI:257900488 DBBJ BAF84742.1 342 unnamed protein product [Homo sapiens]
GI:257900488 DBBJ BAG35991.1 342 unnamed protein product [Homo sapiens]
GI:257900488 GenBank AAB24695.2 342 platelet-activating factor receptor [Homo sapiens]
GI:257900488 GenBank AAW10845.1 342 Sequence 555 from patent US 6806054
GI:257900488 GenBank ABJ30557.1 342 Sequence 555 from patent US 7097969
GI:257900488 GenBank ACE50289.1 342 Sequence 555 from patent US 7381522