Gene/Proteome Database (LMPD)
LMPD ID
LMP000458
Gene ID
Species
Homo sapiens (Human)
Gene Name
3-oxoacyl-ACP synthase, mitochondrial
Gene Symbol
Synonyms
FASN2D; KASI; KS
Alternate Names
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; beta-ketoacyl synthase; beta-ketoacyl-ACP synthase; 3-oxoacyl-acyl-carrier-protein synthase; 3-ketoacyl-acyl carrier protein synthase; type II mitochondrial beta-ketoacyl synthase; acyl-malonyl acyl carrier protein-condensing enzyme
Chromosome
3
Map Location
3p24.2
EC Number
2.3.1.41
Summary
This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
Orthologs
Proteins
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1 precursor | |
---|---|
Refseq ID | NP_060367 |
Protein GI | 8923559 |
UniProt ID | Q9NWU1 |
mRNA ID | NM_017897 |
Length | 459 |
RefSeq Status | REVIEWED |
MSNCLQNFLKITSTRLLCSRLCQQLRSKRKFFGTVPISRLHRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFNEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSTNSDPKLACRPFHPKRDGFVMGEGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATLCIAGL |
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor | |
---|---|
Refseq ID | NP_001138863 |
Protein GI | 223972627 |
UniProt ID | Q9NWU1 |
mRNA ID | NM_001145391 |
Length | 376 |
RefSeq Status | REVIEWED |
MSNCLQNFLKITSTRLLCSRLCQQLRSKRKFFGTVPISRLHRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFNEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATLCIAGL |
Gene Information
Entrez Gene ID
Gene Name
3-oxoacyl-ACP synthase, mitochondrial
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005739 | IDA:LIFEdb | C | mitochondrion |
GO:0004315 | IDA:HGNC | F | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
GO:0006637 | IDA:HGNC | P | acyl-CoA metabolic process |
GO:0051792 | IDA:HGNC | P | medium-chain fatty acid biosynthetic process |
GO:0051790 | IDA:HGNC | P | short-chain fatty acid biosynthetic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
3-oxoacyl-ACP synthase, mitochondrial
Protein Entry
OXSM_HUMAN
UniProt ID
Species
Human
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NWU1-1; Sequence=Displayed; Name=2; IsoId=Q9NWU1-2; Sequence=VSP_041671; |
Biophysicochemical Properties | Kinetic parameters: KM=3.9 uM for C4-[acyl-carrier-protein] ; KM=1.9 uM for C6-[acyl-carrier-protein] ; KM=10.9 uM for C8-[acyl-carrier-protein] ; KM=1.8 uM for C10-[acyl-carrier-protein] ; KM=9.5 uM for C12-[acyl-carrier-protein] ; KM=50.8 uM for C14-[acyl-carrier-protein] ; Vmax=129 nmol/min/mg enzyme toward C4-[acyl-carrier-protein] ; Vmax=241 nmol/min/mg enzyme toward C6-[acyl-carrier-protein] ; Vmax=271 nmol/min/mg enzyme toward C8-[acyl-carrier-protein] ; Vmax=364 nmol/min/mg enzyme toward C10-[acyl-carrier-protein] ; Vmax=1045 nmol/min/mg enzyme toward C12-[acyl-carrier-protein] ; Vmax=115 nmol/min/mg enzyme toward C14-[acyl-carrier-protein] ; Note=The highest catalytic efficiency is observed for C10-[acyl- carrier-protein].; |
Catalytic Activity | Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. |
Enzyme Regulation | Inhibited by cerulenin. |
Function | May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. |
Pathway | Lipid metabolism; fatty acid biosynthesis. |
Similarity | Belongs to the beta-ketoacyl-ACP synthases family. |
Subcellular Location | Mitochondrion . |
Tissue Specificity | Widely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000458 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
8923559 | RefSeq | NP_060367 | 459 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1 precursor |
223972627 | RefSeq | NP_001138863 | 376 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor |
Identical Sequences to LMP000458 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:8923559 | EMBL | CBN70680.1 | 459 | unnamed protein product [Homo sapiens] |
GI:8923559 | EMBL | CBN69072.1 | 459 | unnamed protein product [Homo sapiens] |
GI:8923559 | GenBank | ADZ15386.1 | 459 | 3-oxoacyl-ACP synthase, mitochondrial, partial [synthetic construct] |
GI:8923559 | GenBank | AED35427.1 | 459 | Sequence 60 from patent US 7879989 |
GI:8923559 | GenBank | AIC51694.1 | 459 | OXSM, partial [synthetic construct] |
GI:8923559 | RefSeq | XP_006713279.1 | 459 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1 [Homo sapiens] |
Related Sequences to LMP000458 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:8923559 | GenBank | JAA02415.1 | 459 | 3-oxoacyl-ACP synthase, mitochondrial [Pan troglodytes] |
GI:8923559 | RefSeq | XP_001164714.1 | 459 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Pan troglodytes] |
GI:8923559 | RefSeq | XP_003826203.1 | 459 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Pan paniscus] |
GI:223972627 | RefSeq | XP_004634253.1 | 376 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X2 [Octodon degus] |
GI:223972627 | RefSeq | XP_004754399.1 | 377 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X3 [Mustela putorius furo] |
GI:223972627 | RefSeq | XP_003480211.2 | 377 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1 [Cavia porcellus] |
GI:223972627 | RefSeq | XP_005545684.1 | 377 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X2 [Macaca fascicularis] |
GI:223972627 | RefSeq | XP_006735948.1 | 376 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X2 [Leptonychotes weddellii] |
GI:223972627 | RefSeq | XP_008151886.1 | 378 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X2 [Eptesicus fuscus] |
GI:8923559 | RefSeq | XP_008949876.1 | 459 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Pan paniscus] |
GI:8923559 | RefSeq | XP_008949877.1 | 459 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Pan paniscus] |
GI:8923559 | RefSeq | XP_009443311.1 | 459 | PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Pan troglodytes] |