Gene/Proteome Database (LMPD)

LMPD ID
LMP000486
Gene ID
14594
Species
Mus musculus (Mouse)
Gene Name
glycoprotein galactosyltransferase alpha 1, 3
Gene Symbol
Ggta1
Synonyms
AW108479; GALT; Gal; Ggta; Ggta-1; alpha3GalT
Alternate Names
N-acetyllactosaminide alpha-1,3-galactosyltransferase; alpha Gal; galactosyltransferase; glycoprotein alpha galactosyl transferase 1; UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
Chromosome
2
Map Location
2 B|2 23.6 cM
EC Number
2.4.1.87

Proteins

N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1
Refseq ID NP_034413
Protein GI 224922808
UniProt ID Q9DBU1
mRNA ID NM_010283
Length 406
RefSeq Status VALIDATED
MITMLQDLHVNKISMSRSKSETSLPSSRSGSQEKIMNVKGKVILLMLIVSTVVVVFWEYVNSPEGSFLWIYHTKIPEVGENRWQKDWWFPSWFKNGTHSYQEDNVEGRREKGRNGDRIEEPQLWDWFNPKNRPDVLTVTPWKAPIVWEGTYDTALLEKYYATQKLTVGLTVFAVGKYIEHYLEDFLESADMYFMVGHRVIFYVMIDDTSRMPVVHLNPLHSLQVFEIRSEKRWQDISMMRMKTIGEHILAHIQHEVDFLFCMDVDQVFQDNFGVETLGQLVAQLQAWWYKASPEKFTYERRELSAAYIPFGEGDFYYHAAIFGGTPTHILNLTRECFKGILQDKKHDIEAQWHDESHLNKYFLFNKPTKILSPEYCWDYQIGLPSDIKSVKVAWQTKEYNLVRNNV
N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2
Refseq ID NP_001139293
Protein GI 224922810
UniProt ID P23336
mRNA ID NM_001145821
Length 394
RefSeq Status VALIDATED
MITMLQDLHVNKISMSRSKSETSLPSSRSGSQEKIMNVKGKVILLMLIVSTVVVVFWEYVNRIPEVGENRWQKDWWFPSWFKNGTHSYQEDNVEGRREKGRNGDRIEEPQLWDWFNPKNRPDVLTVTPWKAPIVWEGTYDTALLEKYYATQKLTVGLTVFAVGKYIEHYLEDFLESADMYFMVGHRVIFYVMIDDTSRMPVVHLNPLHSLQVFEIRSEKRWQDISMMRMKTIGEHILAHIQHEVDFLFCMDVDQVFQDNFGVETLGQLVAQLQAWWYKASPEKFTYERRELSAAYIPFGEGDFYYHAAIFGGTPTHILNLTRECFKGILQDKKHDIEAQWHDESHLNKYFLFNKPTKILSPEYCWDYQIGLPSDIKSVKVAWQTKEYNLVRNNV

Gene Information

Entrez Gene ID
14594
Gene Name
glycoprotein galactosyltransferase alpha 1, 3
Gene Symbol
Ggta1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031985 ISS:UniProtKB C Golgi cisterna
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0047276 IEA:UniProtKB-EC F N-acetyllactosaminide 3-alpha-galactosyltransferase activity
GO:0033580 IDA:UniProtKB P protein galactosylation at cell surface

KEGG Pathway Links

KEGG Pathway ID Description
ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series
mmu00601 Glycosphingolipid biosynthesis - lacto and neolacto series

Domain Information

InterPro Annotations

Accession Description
IPR005076 Glycosyl transferase, family 6
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
glycoprotein galactosyltransferase alpha 1, 3
Protein Entry
Q9DBU1_MOUSE
UniProt ID
Q9DBU1
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23336-1; Sequence=Displayed; Name=2; IsoId=P23336-2; Sequence=VSP_001804; Name=3; IsoId=P23336-3; Sequence=VSP_001804, VSP_001805;
Catalytic Activity UDP-alpha-D-galactose + beta-D-galactosyl- (1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl- (1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Domain The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
Function Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose- alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3). {ECO:0000269|PubMed:12626403}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 6 family. {ECO:0000305}.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Identical and Related Proteins

Unique RefSeq proteins for LMP000486 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
224922808 RefSeq NP_034413 406 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1
224922810 RefSeq NP_001139293 394 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

Identical Sequences to LMP000486 proteins

Reference Database Accession Length Protein Name
GI:224922808 DBBJ BAB23534.1 406 unnamed protein product [Mus musculus]
GI:224922810 DBBJ BAE34805.1 394 unnamed protein product [Mus musculus]
GI:224922810 EMBL CAD19042.1 394 unnamed protein product [Musca sp.]
GI:224922810 GenBank AAB46070.1 394 Sequence 4 from patent US 5595900
GI:224922810 GenBank AAE27789.1 394 Sequence 4 from patent US 5955347
GI:224922810 GenBank AAO31497.1 394 Sequence 2 from patent US 6331658
GI:224922808 GenBank EDL08658.1 406 glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_e [Mus musculus]
GI:224922808 GenBank EDL08659.1 406 glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_e [Mus musculus]
GI:224922810 PRF - 394 galactosyltransferase [Mus musculus]

Related Sequences to LMP000486 proteins

Reference Database Accession Length Protein Name
GI:224922810 DBBJ BAB23534.1 406 unnamed protein product [Mus musculus]
GI:224922808 GenBank AAA37657.1 394 galactosyltransferase (EC 2.4.1.151) [Mus musculus]
GI:224922808 GenBank AAB46070.1 394 Sequence 4 from patent US 5595900
GI:224922808 GenBank AAE27789.1 394 Sequence 4 from patent US 5955347
GI:224922808 GenBank AAO31497.1 394 Sequence 2 from patent US 6331658
GI:224922810 GenBank AAT23493.1 359 Sequence 11 from patent US 6713055
GI:224922810 GenBank EDL08656.1 406 glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_c, partial [Mus musculus]
GI:224922810 GenBank EDL08658.1 406 glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_e [Mus musculus]
GI:224922810 GenBank EDL08659.1 406 glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_e [Mus musculus]
GI:224922808 PRF - 394 galactosyltransferase [Mus musculus]
GI:224922810 RefSeq NP_034413.2 406 N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1 [Mus musculus]
GI:224922808 SwissProt P23336.1 394 RecName: Full=N-acetyllactosaminide alpha-1,3-galactosyltransferase; AltName: Full=UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase; Short=Galactosyltransferase [Mus musculus]