Gene/Proteome Database (LMPD)
LMPD ID
LMP000500
Gene ID
Species
Homo sapiens (Human)
Gene Name
perilipin 1
Gene Symbol
Synonyms
FPLD4; PERI; PLIN
Alternate Names
perilipin-1; lipid droplet-associated protein
Chromosome
15
Map Location
15q26
Summary
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]
Orthologs
Proteins
| perilipin-1 | |
|---|---|
| Refseq ID | NP_002657 |
| Protein GI | 223718196 |
| UniProt ID | O60240 |
| mRNA ID | NM_002666 |
| Length | 522 |
| RefSeq Status | REVIEWED |
| MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS | |
| perilipin-1 | |
|---|---|
| Refseq ID | NP_001138783 |
| Protein GI | 223718203 |
| UniProt ID | O60240 |
| mRNA ID | NM_001145311 |
| Length | 522 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:223718196 (mRNA isoform) | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IEA:Ensembl | C | cytosol |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005811 | NAS:UniProtKB | C | lipid particle |
| GO:0008289 | NAS:UniProtKB | F | lipid binding |
| GO:0006629 | NAS:UniProtKB | P | lipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0019433 | TAS:Reactome | P | triglyceride catabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa03320 | PPAR signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_494 | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| REACT_27161 | Transcriptional regulation of white adipocyte differentiation |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004279 | Perilipin |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disease | Lipodystrophy, familial partial, 4 (FPLD4) [MIM |
| Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
| Ptm | Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity). |
| Similarity | Belongs to the perilipin family. |
| Subcellular Location | Endoplasmic reticulum . Lipid droplet . Note=Lipid droplet surface- associated. |
| Subunit | Interacts with ABHD5 (By similarity). Interacts with CIDEC. |
| Tissue Specificity | Adipocytes. |
| Web Resource | Name=Protein Spotlight; Note=Fat, wonderful fat - Issue 10 of May 2001; URL="http://web.expasy.org/spotlight/back_issues/010"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000500 (as displayed in Record Overview)
Identical Sequences to LMP000500 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:223718196 | RefSeq | NP_001138783.1 | 522 | perilipin-1 [Homo sapiens] |
| GI:223718196 | RefSeq | XP_005254991.1 | 522 | PREDICTED: perilipin-1 isoform X1 [Homo sapiens] |
| GI:223718196 | SwissProt | O60240.2 | 522 | RecName: Full=Perilipin-1; AltName: Full=Lipid droplet-associated protein [Homo sapiens] |
Related Sequences to LMP000500 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:223718196 | DBBJ | BAA25420.1 | 522 | perilipin [Homo sapiens] |
| GI:223718196 | GenBank | AAM56651.1 | 522 | Sequence 23 from patent US 6368794 |
| GI:223718196 | GenBank | EAX02061.1 | 522 | perilipin [Homo sapiens] |
| GI:223718196 | GenBank | ACM80760.1 | 522 | Sequence 6258 from patent US 6812339 |
| GI:223718196 | GenBank | ACM84150.1 | 525 | Sequence 9648 from patent US 6812339 |
| GI:223718196 | GenBank | AHD75529.1 | 522 | Sequence 17292 from patent US 8586006 |