Gene/Proteome Database (LMPD)

LMPD ID
LMP000513
Gene ID
20775
Species
Mus musculus (Mouse)
Gene Name
squalene epoxidase
Gene Symbol
Sqle
Synonyms
AI323792
Alternate Names
squalene monooxygenase; SE
Chromosome
15
Map Location
15 D1|15
EC Number
1.14.13.132

Proteins

squalene monooxygenase
Refseq ID NP_033296
Protein GI 6678127
UniProt ID P52019
mRNA ID NM_009270
Length 572
RefSeq Status PROVISIONAL
MWTFLGIATFTYFYKKCGDVTLANKELLLCVLVFLSLGLVLSYRCRHRHGGLLGRHQSGAQFAAFSDILSALPLIGFFWAKSPESEKKEQLESKKCRKEIGLSETTLTGAATSVSTSFVTDPEVIIVGSGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGELLQPGGYRVLQELGLGDTVEGLNAHHIHGYIVHDYESRSEVQIPYPLSETNQVQSGIAFHHGRFIMSLRKAAMAEPNVKFIEGVVLQLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKSLISSKVSVSSHFVGFLMKDAPQFKPNFAELVLVNPSPVLIYQISSSETRVLVDIRGELPRNLREYMAEQIYPQLPEHLKESFLEASQNGRLRTMPASFLPPSSVNKRGVLILGDAYNLRHPLTGGGMTVALKDIKLWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRTHSFVVNVLAQALYELFSATDDSLHQLRKACFLYFKLGGECVTGPVGLLSILSPHPLVLIRHFFSVAIYATYFCFKSEPWATKPRALFSSGAVLYKACSILFPLIYSEMKYLVH

Gene Information

Entrez Gene ID
20775
Gene Name
squalene epoxidase
Gene Symbol
Sqle
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0004506 IEA:UniProtKB-EC F squalene monooxygenase activity
GO:0006725 IEA:Ensembl P cellular aromatic compound metabolic process
GO:0008203 IEA:Ensembl P cholesterol metabolic process
GO:0010033 IEA:Ensembl P response to organic substance

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894006 Activation of gene expression by SREBF (SREBP)
5893434 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003042 Aromatic-ring hydroxylase-like
IPR013698 Squalene_epoxidase

UniProt Annotations

Entry Information

Gene Name
squalene epoxidase
Protein Entry
ERG1_MOUSE
UniProt ID
P52019
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Similarity Belongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit May form a complex with squalene synthase.

Identical and Related Proteins

Unique RefSeq proteins for LMP000513 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6678127 RefSeq NP_033296 572 squalene monooxygenase

Identical Sequences to LMP000513 proteins

Reference Database Accession Length Protein Name
GI:6678127 DBBJ BAE37374.1 572 unnamed protein product [Mus musculus]
GI:6678127 GenBank AAE03453.1 572 Sequence 3 from patent US 5861496
GI:6678127 GenBank AAE55205.1 572 Sequence 6 from patent US 6153815
GI:6678127 GenBank AAH42781.1 572 Squalene epoxidase [Mus musculus]
GI:6678127 GenBank AAH56361.1 572 Squalene epoxidase [Mus musculus]
GI:6678127 GenBank EDL29326.1 572 squalene epoxidase [Mus musculus]

Related Sequences to LMP000513 proteins

Reference Database Accession Length Protein Name
GI:6678127 DBBJ BAA07141.1 573 squalene epoxidase [Rattus norvegicus]
GI:6678127 GenBank AAE55206.1 573 Sequence 7 from patent US 6153815
GI:6678127 GenBank AAH97330.1 573 Sqle protein [Rattus norvegicus]
GI:6678127 GenBank EDM16202.1 573 squalene epoxidase [Rattus norvegicus]
GI:6678127 RefSeq NP_058832.1 573 squalene monooxygenase [Rattus norvegicus]
GI:6678127 SwissProt P52020.1 573 RecName: Full=Squalene monooxygenase; AltName: Full=Squalene epoxidase; Short=SE [Rattus norvegicus]