Gene/Proteome Database (LMPD)
LMPD ID
LMP000515
Gene ID
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 5
Gene Symbol
Synonyms
OBPH1; ORP5
Alternate Names
oxysterol-binding protein-related protein 5; ORP-5; OSBP-related protein 5; oxysterol-binding protein homolog 1; oxysterol-binding protein homologue 1
Chromosome
11
Map Location
11p15.4
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Orthologs
Proteins
| oxysterol-binding protein-related protein 5 isoform a | |
|---|---|
| Refseq ID | NP_065947 |
| Protein GI | 14149740 |
| UniProt ID | Q9H0X9 |
| mRNA ID | NM_020896 |
| Length | 879 |
| RefSeq Status | REVIEWED |
| MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK | |
| oxysterol-binding protein-related protein 5 isoform b | |
|---|---|
| Refseq ID | NP_663613 |
| Protein GI | 22035609 |
| UniProt ID | Q9H0X9 |
| mRNA ID | NM_145638 |
| Length | 811 |
| RefSeq Status | REVIEWED |
| MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSVVIMADSLKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK | |
| oxysterol-binding protein-related protein 5 isoform b | |
|---|---|
| Refseq ID | NP_001137535 |
| Protein GI | 221136766 |
| UniProt ID | Q9H0X9 |
| mRNA ID | NM_001144063 |
| Length | 811 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:22035609 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
oxysterol binding protein-like 5
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | NAS:UniProtKB | C | cytosol |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0015485 | IDA:BHF-UCL | F | cholesterol binding |
| GO:0008142 | NAS:UniProtKB | F | oxysterol binding |
| GO:0006893 | NAS:UniProtKB | P | Golgi to plasma membrane transport |
| GO:0008203 | NAS:UniProtKB | P | cholesterol metabolic process |
| GO:0030301 | NAS:UniProtKB | P | cholesterol transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
oxysterol binding protein-like 5
Protein Entry
OSBL5_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H0X9-1; Sequence=Displayed; Name=2; IsoId=Q9H0X9-2; Sequence=VSP_043071; Note=No experimental confirmation available.; |
| Function | May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. |
| Miscellaneous | The gene is imprinted in placenta, where it is predominantly expressed from the maternal allele only. Not imprinted in other tissues. |
| Sequence Caution | Sequence=BAA96058.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence= ; |
| Similarity | Belongs to the OSBP family. |
| Similarity | Contains 1 PH domain. {ECO |
| Subcellular Location | Endoplasmic reticulum membrane ; Single-pass membrane protein . |
| Tissue Specificity | Ubiquitously expressed. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000515 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 14149740 | RefSeq | NP_065947 | 879 | oxysterol-binding protein-related protein 5 isoform a |
| 22035609 | RefSeq | NP_663613 | 811 | oxysterol-binding protein-related protein 5 isoform b |
Identical Sequences to LMP000515 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14149740 | DBBJ | BAB85686.1 | 879 | oxysterol binding protein homologue 1 [Homo sapiens] |
| GI:14149740 | DBBJ | BAG51735.1 | 879 | unnamed protein product [Homo sapiens] |
| GI:22035609 | DBBJ | BAG72670.2 | 811 | oxysterol binding protein-like 5, partial [synthetic construct] |
| GI:22035609 | EMBL | CAL38302.1 | 811 | hypothetical protein, partial [synthetic construct] |
| GI:14149740 | GenBank | AAH39579.1 | 879 | Oxysterol binding protein-like 5 [Homo sapiens] |
| GI:22035609 | GenBank | AAH32646.2 | 811 | Oxysterol binding protein-like 5 [Homo sapiens] |
| GI:22035609 | GenBank | EAX02542.1 | 811 | oxysterol binding protein-like 5, isoform CRA_a [Homo sapiens] |
| GI:14149740 | GenBank | EAX02543.1 | 879 | oxysterol binding protein-like 5, isoform CRA_b [Homo sapiens] |
| GI:14149740 | GenBank | AIC52851.1 | 879 | OSBPL5, partial [synthetic construct] |
| GI:22035609 | GenBank | AIC63657.1 | 811 | OSBPL5, partial [synthetic construct] |
| GI:22035609 | RefSeq | NP_001137535.1 | 811 | oxysterol-binding protein-related protein 5 isoform b [Homo sapiens] |
| GI:14149740 | SwissProt | Q9H0X9.1 | 879 | RecName: Full=Oxysterol-binding protein-related protein 5; Short=ORP-5; Short=OSBP-related protein 5; AltName: Full=Oxysterol-binding protein homolog 1 [Homo sapiens] |
Related Sequences to LMP000515 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22035609 | DBBJ | BAF85689.1 | 811 | unnamed protein product [Homo sapiens] |
| GI:22035609 | DBBJ | BAG62622.1 | 790 | unnamed protein product [Homo sapiens] |
| GI:22035609 | EMBL | CAL37769.1 | 811 | hypothetical protein, partial [synthetic construct] |
| GI:14149740 | GenBank | JAA09117.1 | 879 | oxysterol binding protein-like 5 [Pan troglodytes] |
| GI:14149740 | GenBank | JAA15276.1 | 879 | oxysterol binding protein-like 5 [Pan troglodytes] |
| GI:14149740 | GenBank | JAA27635.1 | 879 | oxysterol binding protein-like 5 [Pan troglodytes] |
| GI:14149740 | GenBank | JAA43316.1 | 879 | oxysterol binding protein-like 5 [Pan troglodytes] |
| GI:14149740 | RefSeq | XP_004050512.1 | 879 | PREDICTED: oxysterol-binding protein-related protein 5 isoform 1 [Gorilla gorilla gorilla] |
| GI:22035609 | RefSeq | XP_004050513.1 | 811 | PREDICTED: oxysterol-binding protein-related protein 5 isoform 2 [Gorilla gorilla gorilla] |
| GI:22035609 | RefSeq | XP_004050514.1 | 790 | PREDICTED: oxysterol-binding protein-related protein 5 isoform 3 [Gorilla gorilla gorilla] |
| GI:22035609 | RefSeq | XP_005576985.1 | 811 | PREDICTED: oxysterol-binding protein-related protein 5 isoform X3 [Macaca fascicularis] |
| GI:14149740 | RefSeq | XP_009458000.1 | 879 | PREDICTED: oxysterol-binding protein-related protein 5 [Pan troglodytes] |