Gene/Proteome Database (LMPD)

LMPD ID
LMP000518
Gene ID
9488
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class B
Gene Symbol
PIGB
Synonyms
GPI-MT-III; PIG-B
Alternate Names
GPI mannosyltransferase 3; GPI mannosyltransferase III; phosphatidylinositol glycan, class B; dol-P-Man dependent GPI mannosyltransferase; phosphatidylinositol-glycan biosynthesis class B protein
Chromosome
15
Map Location
15q21.3
EC Number
2.4.1.-
Summary
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PIGB

Proteins

GPI mannosyltransferase 3
Refseq ID NP_004846
Protein GI 110224465
UniProt ID Q92521
mRNA ID NM_004855
Length 554
RefSeq Status REVIEWED
MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFNMKMKF

Gene Information

Entrez Gene ID
9488
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class B
Gene Symbol
PIGB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:UniProtKB C endoplasmic reticulum membrane
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0000030 IDA:UniProtKB F mannosyltransferase activity
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0006506 IDA:UniProtKB P GPI anchor biosynthetic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0097502 IDA:GOC P mannosylation
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0016254 TAS:Reactome P preassembly of GPI anchor in ER membrane

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_952 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR005599 GPI mannosyltransferase

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class B
Protein Entry
PIGB_HUMAN
UniProt ID
Q92521
Species
Human

Comments

Comment Type Description
Function Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the glycosyltransferase 22 family. PIGB subfamily.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP000518 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110224465 RefSeq NP_004846 554 GPI mannosyltransferase 3

Identical Sequences to LMP000518 proteins

Reference Database Accession Length Protein Name
GI:110224465 DBBJ BAA07709.1 554 PIG-B [Homo sapiens]
GI:110224465 EMBL CAH05366.1 554 unnamed protein product [Homo sapiens]
GI:110224465 GenBank EAW77480.1 554 phosphatidylinositol glycan, class B [Homo sapiens]
GI:110224465 SwissProt Q92521.1 554 RecName: Full=GPI mannosyltransferase 3; AltName: Full=GPI mannosyltransferase III; Short=GPI-MT-III; AltName: Full=Phosphatidylinositol-glycan biosynthesis class B protein; Short=PIG-B [Homo sapiens]

Related Sequences to LMP000518 proteins

Reference Database Accession Length Protein Name
GI:110224465 DBBJ BAD97050.1 554 phosphatidylinositol glycan, class B variant, partial [Homo sapiens]
GI:110224465 DBBJ BAG37253.1 554 unnamed protein product [Homo sapiens]
GI:110224465 EMBL CAH05365.1 554 unnamed protein product [Homo sapiens]
GI:110224465 GenBank ACM85135.1 569 Sequence 10633 from patent US 6812339
GI:110224465 GenBank AEU56647.1 554 Sequence 159 from patent US 8067189
GI:110224465 GenBank AHD71808.1 554 Sequence 6502 from patent US 8586006