Gene/Proteome Database (LMPD)

LMPD ID
LMP000519
Gene ID
128
Species
Homo sapiens (Human)
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
ADH5
Synonyms
ADH-3; ADHX; FALDH; FDH; GSH-FDH; GSNOR
Alternate Names
alcohol dehydrogenase class-3; formaldehyde dehydrogenase; alcohol dehydrogenase class-III; alcohol dehydrogenase class chi chain; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; alcohol dehydrogenase (class III), chi polypeptide
Chromosome
4
Map Location
4q23
EC Number
1.1.1.1
Summary
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Orthologs
View orthologs and multiple alignments for ADH5

Proteins

alcohol dehydrogenase class-3
Refseq ID NP_000662
Protein GI 71565154
UniProt ID P11766
mRNA ID NM_000671
Length 374
RefSeq Status REVIEWED
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI

Gene Information

Entrez Gene ID
128
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
ADH5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0004022 IEA:UniProtKB-EC F alcohol dehydrogenase (NAD) activity
GO:0009055 TAS:UniProtKB F electron carrier activity
GO:0005504 IDA:UniProtKB F fatty acid binding
GO:0018467 IDA:UniProtKB F formaldehyde dehydrogenase activity
GO:0051903 TAS:UniProtKB F S-(hydroxymethyl)glutathione dehydrogenase activity
GO:0008270 IDA:UniProtKB F zinc ion binding
GO:0007568 IEA:Ensembl P aging
GO:0006068 IEA:Ensembl P ethanol catabolic process
GO:0006069 IEA:InterPro P ethanol oxidation
GO:0046294 IEA:Ensembl P formaldehyde catabolic process
GO:0018119 IEA:Ensembl P peptidyl-cysteine S-nitrosylation
GO:0045777 IEA:Ensembl P positive regulation of blood pressure
GO:0003016 IEA:Ensembl P respiratory system process
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0051409 IEA:Ensembl P response to nitrosative stress
GO:0051775 IDA:UniProtKB P response to redox state
GO:0001523 IEA:Ensembl P retinoid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01200 Carbon metabolism
hsa05204 Chemical carcinogenesis
hsa01220 Degradation of aromatic compounds
hsa00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR014183 Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Entry
ADHX_HUMAN
UniProt ID
P11766
Species
Human

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Catalytic Activity S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H.
Cofactor Name=Zn(2+); Xref=ChEBI
Function Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
Miscellaneous There are 7 different ADH's isozymes in human: three belongs to class-I
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Subcellular Location Cytoplasm.
Subunit Homodimer.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh5/";

Identical and Related Proteins

Unique RefSeq proteins for LMP000519 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71565154 RefSeq NP_000662 374 alcohol dehydrogenase class-3

Identical Sequences to LMP000519 proteins

Reference Database Accession Length Protein Name
GI:71565154 DBBJ BAG35285.1 374 unnamed protein product [Homo sapiens]
GI:71565154 DBBJ BAG72455.1 374 alcohol dehydrogenase 5 (class III), chi polypeptide, partial [synthetic construct]
GI:71565154 GenBank AAH70491.2 374 Alcohol dehydrogenase 5 (class III), chi polypeptide [Homo sapiens]
GI:71565154 GenBank ADT48572.1 374 Sequence 589 from patent US 7842467
GI:71565154 GenBank ADT48573.1 374 Sequence 590 from patent US 7842467
GI:71565154 GenBank AIC48225.1 374 ADH5, partial [synthetic construct]

Related Sequences to LMP000519 proteins

Reference Database Accession Length Protein Name
GI:71565154 GenBank AAX37047.1 375 alcohol dehydrogenase 5 chi polypeptide, partial [synthetic construct]
GI:71565154 PDB 1TEH 373 Chain A, Structure Of Human Liver Chichi Alcohol Dehydrogenase (A Glutathione- Dependent Formaldehyde Dehydrogenase)
GI:71565154 PDB 1TEH 373 Chain B, Structure Of Human Liver Chichi Alcohol Dehydrogenase (A Glutathione- Dependent Formaldehyde Dehydrogenase)
GI:71565154 PDB 1M6H 373 Chain A, Human Glutathione-Dependent Formaldehyde Dehydrogenase
GI:71565154 PDB 1M6H 373 Chain B, Human Glutathione-Dependent Formaldehyde Dehydrogenase
GI:71565154 PDB 1M6W 373 Chain A, Binary Complex Of Human Glutathione-Dependent Formaldehyde Dehydrogenase And 12-Hydroxydodecanoic Acid