Gene/Proteome Database (LMPD)
LMPD ID
LMP000520
Gene ID
Species
Homo sapiens (Human)
Gene Name
carnitine palmitoyltransferase 1B (muscle)
Gene Symbol
Synonyms
CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1; MCCPT1; MCPT1
Chromosome
22
Map Location
22q13.33
EC Number
2.3.1.21
Summary
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]
Orthologs
Proteins
carnitine O-palmitoyltransferase 1, muscle isoform isoform a | |
---|---|
Refseq ID | NP_001138607 |
Protein GI | 223468672 |
UniProt ID | Q92523 |
mRNA ID | NM_001145135 |
Length | 772 |
RefSeq Status | REVIEWED |
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS |
carnitine O-palmitoyltransferase 1, muscle isoform isoform a | |
---|---|
Refseq ID | NP_001138609 |
Protein GI | 223468678 |
UniProt ID | Q92523 |
mRNA ID | NM_001145137 |
Length | 772 |
RefSeq Status | REVIEWED |
Protein sequence is identical to GI:223468672 (mRNA isoform) |
carnitine O-palmitoyltransferase 1, muscle isoform isoform a | |
---|---|
Refseq ID | NP_689452 |
Protein GI | 23238256 |
UniProt ID | Q92523 |
mRNA ID | NM_152246 |
Length | 772 |
RefSeq Status | REVIEWED |
Protein sequence is identical to GI:223468672 (mRNA isoform) |
carnitine O-palmitoyltransferase 1, muscle isoform isoform a | |
---|---|
Refseq ID | NP_004368 |
Protein GI | 4758050 |
UniProt ID | Q92523 |
mRNA ID | NM_004377 |
Length | 772 |
RefSeq Status | REVIEWED |
Protein sequence is identical to GI:223468672 (mRNA isoform) |
carnitine O-palmitoyltransferase 1, muscle isoform isoform a | |
---|---|
Refseq ID | NP_689451 |
Protein GI | 23238254 |
UniProt ID | Q92523 |
mRNA ID | NM_152245 |
Length | 772 |
RefSeq Status | REVIEWED |
Protein sequence is identical to GI:223468672 (mRNA isoform) |
carnitine O-palmitoyltransferase 1, muscle isoform isoform c | |
---|---|
Refseq ID | NP_001138606 |
Protein GI | 223468670 |
UniProt ID | Q92523 |
mRNA ID | NM_001145134 |
Length | 738 |
RefSeq Status | REVIEWED |
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS |
Gene Information
Entrez Gene ID
Gene Name
carnitine palmitoyltransferase 1B (muscle)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0005741 | TAS:Reactome | C | mitochondrial outer membrane |
GO:0005739 | IDA:UniProt | C | mitochondrion |
GO:0004095 | TAS:ProtInc | F | carnitine O-palmitoyltransferase activity |
GO:0006853 | TAS:Reactome | P | carnitine shuttle |
GO:0044255 | TAS:Reactome | P | cellular lipid metabolic process |
GO:0006635 | TAS:ProtInc | P | fatty acid beta-oxidation |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR000542 | Acyltransferase ChoActase/COT/CPT |
UniProt Annotations
Entry Information
Gene Name
carnitine palmitoyltransferase 1B (muscle)
Protein Entry
CPT1B_HUMAN
UniProt ID
Species
Human
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q92523-1; Sequence=Displayed; Name=2; IsoId=Q92523-2; Sequence=VSP_034246, VSP_034247; Name=3; IsoId=Q92523-3; Sequence=VSP_043184; Note=No experimental confirmation available.; Name=4; IsoId=Q92523-4; Sequence=VSP_044451; Note=No experimental confirmation available.; |
Catalytic Activity | Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine. |
Miscellaneous | This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame. |
Pathway | Lipid metabolism; fatty acid beta-oxidation. |
Sequence Caution | Sequence=BAB33340.1; Type=Erroneous initiation; Evidence= ; |
Similarity | Belongs to the carnitine/choline acetyltransferase family. |
Subcellular Location | Mitochondrion outer membrane; Multi-pass membrane protein. |
Tissue Specificity | Strong expression in heart and skeletal muscle. No expression in liver and kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000520 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
223468672 | RefSeq | NP_001138607 | 772 | carnitine O-palmitoyltransferase 1, muscle isoform isoform a |
223468670 | RefSeq | NP_001138606 | 738 | carnitine O-palmitoyltransferase 1, muscle isoform isoform c |
Identical Sequences to LMP000520 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:223468670 | DBBJ | BAH12680.1 | 738 | unnamed protein product [Homo sapiens] |
GI:223468672 | GenBank | ADS30353.1 | 772 | Sequence 885 from patent US 7781168 |
GI:223468672 | GenBank | ADS30354.1 | 772 | Sequence 886 from patent US 7781168 |
GI:223468672 | GenBank | ADS30355.1 | 772 | Sequence 887 from patent US 7781168 |
GI:223468672 | GenBank | AHD74508.1 | 772 | Sequence 14525 from patent US 8586006 |
GI:223468672 | GenBank | AHD74509.1 | 772 | Sequence 14526 from patent US 8586006 |
GI:223468672 | GenBank | AHD74510.1 | 772 | Sequence 14527 from patent US 8586006 |
Related Sequences to LMP000520 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:223468670 | DBBJ | BAA13461.1 | 772 | carnitine palmitoyltransferase I [Homo sapiens] |
GI:223468670 | DBBJ | BAA21492.1 | 772 | muscle type carnitine palmitoyltransferase I [Homo sapiens] |
GI:223468672 | DBBJ | BAD96894.1 | 772 | carnitine palmitoyltransferase 1B isoform a variant, partial [Homo sapiens] |
GI:223468670 | EMBL | CAA69938.1 | 772 | carnitine palmitoyltransferase I [Homo sapiens] |
GI:223468670 | EMBL | CAA69939.1 | 772 | carnitine palmitoyltransferase I [Homo sapiens] |
GI:223468672 | GenBank | AAC51122.1 | 772 | carnitine palmitoyltransferase I [Homo sapiens] |
GI:223468670 | GenBank | AAB40651.1 | 772 | carnitine palmitoyltransferase I [Homo sapiens] |
GI:223468672 | GenBank | AAI42955.1 | 772 | CPT1B protein [Homo sapiens] |
GI:223468672 | GenBank | AAI43072.1 | 772 | Carnitine palmitoyltransferase 1B (muscle), partial [synthetic construct] |
GI:223468672 | GenBank | AAI50319.1 | 772 | Carnitine palmitoyltransferase 1B (muscle), partial [synthetic construct] |
GI:223468672 | GenBank | AIC54215.1 | 772 | CPT1B, partial [synthetic construct] |
GI:223468670 | RefSeq | XP_003779631.2 | 738 | PREDICTED: carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [Pongo abelii] |