Gene/Proteome Database (LMPD)

LMPD ID
LMP000520
Gene ID
1375
Species
Homo sapiens (Human)
Gene Name
carnitine palmitoyltransferase 1B (muscle)
Gene Symbol
CPT1B
Synonyms
CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1; MCCPT1; MCPT1
Chromosome
22
Map Location
22q13.33
EC Number
2.3.1.21
Summary
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]
Orthologs
View orthologs and multiple alignments for CPT1B

Proteins

carnitine O-palmitoyltransferase 1, muscle isoform isoform a
Refseq ID NP_001138607
Protein GI 223468672
UniProt ID Q92523
mRNA ID NM_001145135
Length 772
RefSeq Status REVIEWED
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS
carnitine O-palmitoyltransferase 1, muscle isoform isoform a
Refseq ID NP_001138609
Protein GI 223468678
UniProt ID Q92523
mRNA ID NM_001145137
Length 772
RefSeq Status REVIEWED
Protein sequence is identical to GI:223468672 (mRNA isoform)
carnitine O-palmitoyltransferase 1, muscle isoform isoform a
Refseq ID NP_689452
Protein GI 23238256
UniProt ID Q92523
mRNA ID NM_152246
Length 772
RefSeq Status REVIEWED
Protein sequence is identical to GI:223468672 (mRNA isoform)
carnitine O-palmitoyltransferase 1, muscle isoform isoform a
Refseq ID NP_004368
Protein GI 4758050
UniProt ID Q92523
mRNA ID NM_004377
Length 772
RefSeq Status REVIEWED
Protein sequence is identical to GI:223468672 (mRNA isoform)
carnitine O-palmitoyltransferase 1, muscle isoform isoform a
Refseq ID NP_689451
Protein GI 23238254
UniProt ID Q92523
mRNA ID NM_152245
Length 772
RefSeq Status REVIEWED
Protein sequence is identical to GI:223468672 (mRNA isoform)
carnitine O-palmitoyltransferase 1, muscle isoform isoform c
Refseq ID NP_001138606
Protein GI 223468670
UniProt ID Q92523
mRNA ID NM_001145134
Length 738
RefSeq Status REVIEWED
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS

Gene Information

Entrez Gene ID
1375
Gene Name
carnitine palmitoyltransferase 1B (muscle)
Gene Symbol
CPT1B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005741 TAS:Reactome C mitochondrial outer membrane
GO:0005739 IDA:UniProt C mitochondrion
GO:0004095 TAS:ProtInc F carnitine O-palmitoyltransferase activity
GO:0006853 TAS:Reactome P carnitine shuttle
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0006635 TAS:ProtInc P fatty acid beta-oxidation
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
hsa04152 AMPK signaling pathway
hsa03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine palmitoyltransferase 1B (muscle)
Protein Entry
CPT1B_HUMAN
UniProt ID
Q92523
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q92523-1; Sequence=Displayed; Name=2; IsoId=Q92523-2; Sequence=VSP_034246, VSP_034247; Name=3; IsoId=Q92523-3; Sequence=VSP_043184; Note=No experimental confirmation available.; Name=4; IsoId=Q92523-4; Sequence=VSP_044451; Note=No experimental confirmation available.;
Catalytic Activity Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine.
Miscellaneous This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Sequence Caution Sequence=BAB33340.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the carnitine/choline acetyltransferase family.
Subcellular Location Mitochondrion outer membrane; Multi-pass membrane protein.
Tissue Specificity Strong expression in heart and skeletal muscle. No expression in liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP000520 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
223468672 RefSeq NP_001138607 772 carnitine O-palmitoyltransferase 1, muscle isoform isoform a
223468670 RefSeq NP_001138606 738 carnitine O-palmitoyltransferase 1, muscle isoform isoform c

Identical Sequences to LMP000520 proteins

Reference Database Accession Length Protein Name
GI:223468670 DBBJ BAH12680.1 738 unnamed protein product [Homo sapiens]
GI:223468672 GenBank ADS30353.1 772 Sequence 885 from patent US 7781168
GI:223468672 GenBank ADS30354.1 772 Sequence 886 from patent US 7781168
GI:223468672 GenBank ADS30355.1 772 Sequence 887 from patent US 7781168
GI:223468672 GenBank AHD74508.1 772 Sequence 14525 from patent US 8586006
GI:223468672 GenBank AHD74509.1 772 Sequence 14526 from patent US 8586006
GI:223468672 GenBank AHD74510.1 772 Sequence 14527 from patent US 8586006

Related Sequences to LMP000520 proteins

Reference Database Accession Length Protein Name
GI:223468670 DBBJ BAA13461.1 772 carnitine palmitoyltransferase I [Homo sapiens]
GI:223468670 DBBJ BAA21492.1 772 muscle type carnitine palmitoyltransferase I [Homo sapiens]
GI:223468672 DBBJ BAD96894.1 772 carnitine palmitoyltransferase 1B isoform a variant, partial [Homo sapiens]
GI:223468670 EMBL CAA69938.1 772 carnitine palmitoyltransferase I [Homo sapiens]
GI:223468670 EMBL CAA69939.1 772 carnitine palmitoyltransferase I [Homo sapiens]
GI:223468672 GenBank AAC51122.1 772 carnitine palmitoyltransferase I [Homo sapiens]
GI:223468670 GenBank AAB40651.1 772 carnitine palmitoyltransferase I [Homo sapiens]
GI:223468672 GenBank AAI42955.1 772 CPT1B protein [Homo sapiens]
GI:223468672 GenBank AAI43072.1 772 Carnitine palmitoyltransferase 1B (muscle), partial [synthetic construct]
GI:223468672 GenBank AAI50319.1 772 Carnitine palmitoyltransferase 1B (muscle), partial [synthetic construct]
GI:223468672 GenBank AIC54215.1 772 CPT1B, partial [synthetic construct]
GI:223468670 RefSeq XP_003779631.2 738 PREDICTED: carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [Pongo abelii]