Gene/Proteome Database (LMPD)

LMPD ID
LMP000529
Gene ID
11992
Species
Mus musculus (Mouse)
Gene Name
AU RNA binding protein/enoyl-coenzyme A hydratase
Gene Symbol
Auh
Synonyms
C77140; W91705
Alternate Names
methylglutaconyl-CoA hydratase, mitochondrial; muAUH; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase
Chromosome
13
Map Location
13 B1|13
EC Number
4.2.1.18

Proteins

methylglutaconyl-CoA hydratase, mitochondrial precursor
Refseq ID NP_057918
Protein GI 116268115
UniProt ID Q9JLZ3
mRNA ID NM_016709
Length 314
RefSeq Status VALIDATED
MAAAAPGALGALRTVGVRLVAACCARLGPAAWARGTAPRRGYSSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRSVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE
transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9JLZ3.1) calculated_mol_wt: 4152 peptide sequence: MAAAAPGALGALRTVGVRLVAACCARLGPAAWARGTAPRRGY mat_peptide: 43..314 product: Methylglutaconyl-CoA hydratase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9JLZ3.1) calculated_mol_wt: 29204 peptide sequence: SSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRSVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE

Gene Information

Entrez Gene ID
11992
Gene Name
AU RNA binding protein/enoyl-coenzyme A hydratase
Gene Symbol
Auh
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 ISS:UniProtKB C mitochondrion
GO:0004300 ISS:UniProtKB F enoyl-CoA hydratase activity
GO:0004490 IEA:UniProtKB-EC F methylglutaconyl-CoA hydratase activity
GO:0003730 ISS:UniProtKB F mRNA 3'-UTR binding
GO:0003723 IDA:MGI F RNA binding
GO:0006552 IEA:UniProtKB-UniPathway P leucine catabolic process
GO:0000288 TAS:MGI P nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

REACTOME Pathway Links

REACTOME Pathway ID Description
5892792 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR014748 Crontonase, C-terminal
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
AU RNA binding protein/enoyl-coenzyme A hydratase
Protein Entry
AUHM_MOUSE
UniProt ID
Q9JLZ3
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JLZ3-1; Sequence=Displayed; Name=2; IsoId=Q9JLZ3-2; Sequence=VSP_008337, VSP_008340; Note=No experimental confirmation available.; Name=3; IsoId=Q9JLZ3-3; Sequence=VSP_008338, VSP_008339; Note=No experimental confirmation available.;
Catalytic Activity (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3- methylglutaconyl-CoA + H(2)O.
Function Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (By similarity). {ECO:0000250}.
Pathway Amino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:10072761}.
Subunit Homohexamer. {ECO:0000250}.
Tissue Specificity Detected in heart, brain, liver, spleen, skeletal muscle and kidney. {ECO:0000269|PubMed:10072761}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000529 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116268115 RefSeq NP_057918 314 methylglutaconyl-CoA hydratase, mitochondrial precursor

Identical Sequences to LMP000529 proteins

Reference Database Accession Length Protein Name
GI:116268115 GenBank AAH49597.1 314 AU RNA binding protein/enoyl-coenzyme A hydratase [Mus musculus]

Related Sequences to LMP000529 proteins

Reference Database Accession Length Protein Name
GI:116268115 GenBank AAF28835.1 314 AU-binding enoyl-CoA hydratase [Mus musculus]
GI:116268115 GenBank EDL41118.1 317 AU RNA binding protein/enoyl-coenzyme A hydratase, isoform CRA_b, partial [Mus musculus]
GI:116268115 GenBank EDL98065.1 315 AU RNA binding protein/enoyl-coenzyme A hydratase (predicted), isoform CRA_a [Rattus norvegicus]
GI:116268115 RefSeq XP_006253736.1 315 PREDICTED: methylglutaconyl-CoA hydratase, mitochondrial isoform X1 [Rattus norvegicus]
GI:116268115 RefSeq XP_006976904.1 314 PREDICTED: methylglutaconyl-CoA hydratase, mitochondrial isoform X1 [Peromyscus maniculatus bairdii]
GI:116268115 SwissProt Q9JLZ3.1 314 RecName: Full=Methylglutaconyl-CoA hydratase, mitochondrial; AltName: Full=AU-specific RNA-binding enoyl-CoA hydratase; Short=AU-binding enoyl-CoA hydratase; Short=muAUH; Flags: Precursor [Mus musculus]