Gene/Proteome Database (LMPD)

LMPD ID
LMP000538
Gene ID
56632
Species
Mus musculus (Mouse)
Gene Name
sphingosine kinase 2
Gene Symbol
Sphk2
Synonyms
C76851
Chromosome
7
Map Location
7 B4|7
Summary
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Orthologs
View orthologs and multiple alignments for Sphk2

Proteins

sphingosine kinase 2
Refseq ID NP_001166032
Protein GI 289191399
UniProt ID Q58E38
mRNA ID NM_001172561
Length 617
RefSeq Status REVIEWED
MAPPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQRLRPKPEARPRDGLVSLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRADGATTYEENRAEAQRWATALTCLLRGVPLSGDQEITPELLPRKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQVVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEPALPIPGHSLPRAKSELVLAPAPAPAATHSPLHRSVSDLPLPLPQPALVSPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEASTWGPVDHLLPPLGSPLPQDWVTIEGEFVLMLGILPSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYAAARAFRLEPLTPRGLLTVDGELVEYGPIQAQVHPGLATLLTGPAGQKPQA
sphingosine kinase 2
Refseq ID NP_975009
Protein GI 42544000
UniProt ID Q3U912
mRNA ID NM_203280
Length 617
RefSeq Status REVIEWED
Protein sequence is identical to GI:289191399 (mRNA isoform)
sphingosine kinase 2
Refseq ID NP_064395
Protein GI 31981070
UniProt ID Q58E38
mRNA ID NM_020011
Length 617
RefSeq Status REVIEWED
Protein sequence is identical to GI:289191399 (mRNA isoform)

Gene Information

Entrez Gene ID
56632
Gene Name
sphingosine kinase 2
Gene Symbol
Sphk2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0017050 IDA:MGI F D-erythro-sphingosine kinase activity
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:InterPro F diacylglycerol kinase activity
GO:0001568 IGI:MGI P blood vessel development
GO:0007420 IGI:MGI P brain development
GO:0008284 IGI:MGI P positive regulation of cell proliferation
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0006670 IMP:MGI P sphingosine metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
sphingosine kinase 2
Protein Entry
SPHK2_MOUSE
UniProt ID
Q58E38
Species
Mouse

Identical and Related Proteins

Unique RefSeq proteins for LMP000538 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
289191399 RefSeq NP_001166032 617 sphingosine kinase 2

Identical Sequences to LMP000538 proteins

Reference Database Accession Length Protein Name
GI:289191399 DBBJ BAE32512.1 617 unnamed protein product [Mus musculus]
GI:289191399 GenBank EDL22887.1 617 sphingosine kinase 2, isoform CRA_a [Mus musculus]
GI:289191399 GenBank EDL22888.1 617 sphingosine kinase 2, isoform CRA_a [Mus musculus]
GI:289191399 GenBank EDL22889.1 617 sphingosine kinase 2, isoform CRA_a [Mus musculus]
GI:289191399 RefSeq XP_006541075.1 617 PREDICTED: sphingosine kinase 2 isoform X1 [Mus musculus]
GI:289191399 RefSeq XP_006541076.1 617 PREDICTED: sphingosine kinase 2 isoform X2 [Mus musculus]

Related Sequences to LMP000538 proteins

Reference Database Accession Length Protein Name
GI:289191399 DBBJ BAE30855.1 617 unnamed protein product [Mus musculus]
GI:289191399 EMBL CBH26132.1 617 unnamed protein product [Mus musculus]
GI:289191399 GenBank AAW06879.1 617 Sequence 12 from patent US 6800470
GI:289191399 GenBank ACJ97775.1 617 Sequence 12 from patent US 7419814
GI:289191399 GenBank ADS49013.1 617 Sequence 12 from patent US 7803595
GI:289191399 GenBank AFS96147.1 617 Sequence 12 from patent US 8263349