Gene/Proteome Database (LMPD)

LMPD ID
LMP000544
Gene ID
56690
Species
Mus musculus (Mouse)
Gene Name
malonyl-CoA decarboxylase
Gene Symbol
Mlycd
Synonyms
AI324784; Mcd
Alternate Names
malonyl-CoA decarboxylase, mitochondrial
Chromosome
8
Map Location
8 E1|8
EC Number
4.1.1.9

Proteins

malonyl-CoA decarboxylase, mitochondrial
Refseq ID NP_064350
Protein GI 56797739
UniProt ID Q99J39
mRNA ID NM_019966
Length 492
RefSeq Status PROVISIONAL
MRGLGPGLRARRLLPLRSPPRPPGPRGRRLCGGLAASAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAEASQRAELLGRLAQGFGVDHGQVAEQSAGVLQLRQQAREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPHVREMNGVLKSMLSEWFSSGFLNLERVTWHSPCEVLQKISECEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISNNIQGIVKECPPTETEERNRIAAAIFYSISLTQQGLQGVELGTFLIKRVVKELQKEFPQLGAFSSLSPIPGFTKWLLGLLNVQGKEHGRNELFTDSECQEISAVTGNPVHESLKGFLSSGEWVKSEKLTQALQGPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVMWRINWMADSSLKGLTSSCGLMVNYRYYLEETGPNSISYLGSKNIKASEQILSLVAQFQNNSKL

Gene Information

Entrez Gene ID
56690
Gene Name
malonyl-CoA decarboxylase
Gene Symbol
Mlycd
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0005759 IDA:UniProtKB C mitochondrial matrix
GO:0005739 IDA:MGI C mitochondrion
GO:0005782 ISS:UniProtKB C peroxisomal matrix
GO:0005777 ISS:UniProtKB C peroxisome
GO:0050080 IDA:UniProtKB F malonyl-CoA decarboxylase activity
GO:0006085 ISS:UniProtKB P acetyl-CoA biosynthetic process
GO:0006633 ISS:UniProtKB P fatty acid biosynthetic process
GO:0019395 IEA:Ensembl P fatty acid oxidation
GO:2001294 IDA:UniProtKB P malonyl-CoA catabolic process
GO:0046321 IDA:UniProtKB P positive regulation of fatty acid oxidation
GO:0031998 IEA:Ensembl P regulation of fatty acid beta-oxidation
GO:0010906 ISS:UniProtKB P regulation of glucose metabolic process
GO:0002931 ISS:UniProtKB P response to ischemia

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
mmu04152 AMPK signaling pathway
mmu01100 Metabolic pathways
mmu04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR007956 Malonyl-CoA decarboxylase

UniProt Annotations

Entry Information

Gene Name
malonyl-CoA decarboxylase
Protein Entry
DCMC_MOUSE
UniProt ID
Q99J39
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative initiation; Named isoforms=2; Comment=A single transcription start site has been demonstrated in Rat.; Name=Mitochondrial; IsoId=Q99J39-1; Sequence=Displayed; Name=Cytoplasmic+peroxisomal; IsoId=Q99J39-2; Sequence=VSP_018817; Note=May be produced by alternative initiation at Met-39 of isoform mitochondrial. Alternatively, represents a proteolytic processed form of the mitochondrial form.;
Catalytic Activity Malonyl-CoA = acetyl-CoA + CO(2). {ECO:0000269|PubMed:17030679}.
Disruption Phenotype Mice show an increased expression of genes regulating fatty acid utilization and likely contributes to the absence of changes in energy metabolism in the aerobic heart. Display a preference for glucose utilization after ischemia and improve functional recovery of the heart. {ECO:0000269|PubMed:17030679}.
Enzyme Regulation Malonyl-CoA decarboxylase activity does not require any cofactors or divalent metal ions. {ECO:0000250}.
Function Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. Plays a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:17030679, ECO:0000269|PubMed:23746352}.
Pathway Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1.
Ptm Acetylation at Lys-471 activates malonyl-CoA decarboxylase activity. Deacetylation at Lys-471 by SIRT4 represses activity, leading to promote lipogenesis. {ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:23746352}.
Ptm Interchain disulfide bonds may form in peroxisomes (Potential). Interchain disulfide bonds are not expected to form in the reducing environment of the cytoplasm and mitochondria. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:23746352}. Peroxisome {ECO:0000250}. Peroxisome matrix {ECO:0000250}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250}.
Subunit Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000544 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
56797739 RefSeq NP_064350 492 malonyl-CoA decarboxylase, mitochondrial

Identical Sequences to LMP000544 proteins

Reference Database Accession Length Protein Name
GI:56797739 DBBJ BAC38505.1 492 unnamed protein product [Mus musculus]
GI:56797739 GenBank AAH04764.1 492 Malonyl-CoA decarboxylase [Mus musculus]
GI:56797739 SwissProt Q99J39.1 492 RecName: Full=Malonyl-CoA decarboxylase, mitochondrial; Short=MCD; Flags: Precursor [Mus musculus]

Related Sequences to LMP000544 proteins

Reference Database Accession Length Protein Name
GI:56797739 GenBank AAL09352.1 492 malonyl-CoA decarboxylase [Rattus norvegicus]
GI:56797739 GenBank AAH61845.1 492 Malonyl-CoA decarboxylase [Rattus norvegicus]
GI:56797739 GenBank EDL92663.1 492 malonyl-CoA decarboxylase [Rattus norvegicus]
GI:56797739 RefSeq NP_445929.1 491 malonyl-CoA decarboxylase, mitochondrial [Rattus norvegicus]
GI:56797739 RefSeq XP_006531281.1 474 PREDICTED: malonyl-CoA decarboxylase, mitochondrial isoform X1 [Mus musculus]
GI:56797739 SwissProt Q920F5.1 492 RecName: Full=Malonyl-CoA decarboxylase, mitochondrial; Short=MCD; Flags: Precursor [Rattus norvegicus]