Gene/Proteome Database (LMPD)
LMPD ID
LMP000576
Gene ID
Species
Mus musculus (Mouse)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
Gene Symbol
Synonyms
1110013A05Rik; D8Ertd319e
Alternate Names
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-AGPAT 5; LPAAT-epsilon; 1-AGP acyltransferase 5; lysophosphatidic acid acyltransferase epsilon
Chromosome
8
Map Location
8 A3|8 10.3 cM
EC Number
2.3.1.51
Proteins
| 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon | |
|---|---|
| Refseq ID | NP_081068 |
| Protein GI | 27229077 |
| UniProt ID | Q9D1E8 |
| mRNA ID | NM_026792 |
| Length | 365 |
| RefSeq Status | VALIDATED |
| MLLSLVLHTYSMRYLLPSVLLLGSAPTYLLAWTLWRVLSALMPARLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSHLDAIYDVTVVYEGNEKGSGKYSNPPSMTEFLCKQCPKLHIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYDSPDPERRNKFPGKSVHSRLSVKKTLPSVLILGSLTAVMLMTESGRKLYMGTWLYGTLLGCLWFVIKA | |
Gene Information
Entrez Gene ID
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0003841 | IDA:MGI | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0016024 | IEA:UniProtKB-UniPathway | P | CDP-diacylglycerol biosynthetic process |
| GO:0006639 | IDA:MGI | P | acylglycerol metabolic process |
| GO:0002244 | IGI:MGI | P | hematopoietic progenitor cell differentiation |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| TRIGLSYN-PWY | triacylglycerol biosynthesis |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002123 | Phospholipid/glycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
Protein Entry
PLCE_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Caution | It is uncertain whether Met-1 or Met-12 is the initiator. {ECO:0000305}. |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}. |
| Function | Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable. {ECO:0000269|PubMed:15367102}. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}. Mitochondrion {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15367102}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000576 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 27229077 | RefSeq | NP_081068 | 365 | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon |
Identical Sequences to LMP000576 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:27229077 | DBBJ | BAE33229.1 | 365 | unnamed protein product [Mus musculus] |
| GI:27229077 | DBBJ | BAE31436.1 | 365 | unnamed protein product [Mus musculus] |
| GI:27229077 | DBBJ | BAE31572.1 | 365 | unnamed protein product [Mus musculus] |
| GI:27229077 | GenBank | AAH31987.2 | 365 | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) [Mus musculus] |
| GI:27229077 | GenBank | EDL22218.1 | 365 | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon), isoform CRA_a [Mus musculus] |
| GI:27229077 | SwissProt | Q9D1E8.2 | 365 | RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 5; Short=1-AGP acyltransferase 5; Short=1-AGPAT 5; AltName: Full=Lysophosphatidic acid acyltransferase epsilon; Short=LPAAT-epsilon [Mus musculus] |
Related Sequences to LMP000576 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:27229077 | DBBJ | BAE41558.1 | 365 | unnamed protein product [Mus musculus] |
| GI:27229077 | GenBank | AAN75571.1 | 365 | 1-acylglycerolphosphate acyltransferase-epsilon [Mus musculus] |
| GI:27229077 | GenBank | ABP22957.1 | 354 | Sequence 74 from patent US 7189833 |
| GI:27229077 | GenBank | EDM08959.1 | 365 | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) (predicted) [Rattus norvegicus] |
| GI:27229077 | RefSeq | XP_005082657.1 | 365 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [Mesocricetus auratus] |
| GI:27229077 | RefSeq | XP_006253443.1 | 365 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [Rattus norvegicus] |