Gene/Proteome Database (LMPD)

LMPD ID
LMP000577
Gene ID
233549
Species
Mus musculus (Mouse)
Gene Name
monoacylglycerol O-acyltransferase 2
Gene Symbol
Mogat2
Synonyms
DGAT2L5; MGAT2; Mgat1l
Alternate Names
2-acylglycerol O-acyltransferase 2; acyl CoA:monoacylglycerol acyltransferase 2; acyl-CoA:monoacylglycerol acyltransferase 2; diacylglycerol acyltransferase 2-like protein 5
Chromosome
7
Map Location
7 E2|7
EC Number
2.3.1.22

Proteins

2-acylglycerol O-acyltransferase 2
Refseq ID NP_803231
Protein GI 28974982
UniProt ID Q80W94
mRNA ID NM_177448
Length 334
RefSeq Status VALIDATED
MVEFAPLLVPWERRLQTFAVLQWVFSFLALAQLCIVIFVGLLFTRFWLFSVLYATWWYLDWDKPRQGGRPIQFFRRLAIWKYMKDYFPVSLVKTAELDPSRNYIAGFHPHGVLAAGAFLNLCTESTGFTSLFPGIRSYLMMLTVWFRAPFFRDYIMSGGLVSSEKVSADHILSRKGGGNLLAIIVGGAQEALDARPGAYRLLLKNRKGFIRLALMHGAALVPIFSFGENNLFNQVENTPGTWLRWIQNRLQKIMGISLPLFHGRGVFQYSFGLMPFRQPITTIVGKPIEVQMTPQPSREEVDRLHQRYIKELCKLFEEHKLKFNVPEDQHLEFC

Gene Information

Entrez Gene ID
233549
Gene Name
monoacylglycerol O-acyltransferase 2
Gene Symbol
Mogat2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003846 IDA:MGI F 2-acylglycerol O-acyltransferase activity
GO:0016407 IDA:MGI F acetyltransferase activity
GO:0006651 IDA:MGI P diacylglycerol biosynthetic process
GO:0006071 IEA:UniProtKB-KW P glycerol metabolic process
GO:0050892 IDA:MGI P intestinal absorption
GO:0006629 IDA:MGI P lipid metabolic process
GO:0046462 ISA:MGI P monoacylglycerol metabolic process
GO:0019432 IDA:MGI P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04975 Fat digestion and absorption
mmu04975 Fat digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR007130 Diacylglycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
monoacylglycerol O-acyltransferase 2
Protein Entry
MOGT2_MOUSE
UniProt ID
Q80W94
Species
Mouse

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 7.0. {ECO:0000269|PubMed:12730219};
Catalytic Activity Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Enzyme Regulation Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid. {ECO:0000269|PubMed:12730219}.
Function Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269|PubMed:12576479, ECO:0000269|PubMed:12730219, ECO:0000269|PubMed:14966132}.
Induction Up-regulated in mice fed a high fat diet, implicating a role in diet-induced obesity (at protein level). {ECO:0000269|PubMed:14966132}.
Pathway Glycerolipid metabolism; triacylglycerol biosynthesis.
Similarity Belongs to the diacylglycerol acyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14966132}; Multi-pass membrane protein {ECO:0000269|PubMed:14966132}.
Tissue Specificity Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus. {ECO:0000269|PubMed:12576479, ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:14966132}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000577 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28974982 RefSeq NP_803231 334 2-acylglycerol O-acyltransferase 2

Identical Sequences to LMP000577 proteins

Reference Database Accession Length Protein Name
GI:28974982 EMBL CBF67539.1 334 unnamed protein product [Mus musculus]
GI:28974982 EMBL CBV04418.1 334 unnamed protein product [Mus musculus]
GI:28974982 EMBL CBU92412.1 334 unnamed protein product [Mus musculus]
GI:28974982 GenBank AFQ73192.1 334 Sequence 4 from patent US 8232447
GI:28974982 GenBank AGX59579.1 334 Sequence 19437 from patent US 8541208
GI:28974982 GenBank AGX72244.1 334 Sequence 44287 from patent US 8541208

Related Sequences to LMP000577 proteins

Reference Database Accession Length Protein Name
GI:28974982 GenBank EDM18418.1 334 rCG39457, isoform CRA_b [Rattus norvegicus]
GI:28974982 GenBank AAI66995.1 334 Mogat2 protein [Rattus norvegicus]
GI:28974982 GenBank EGW14770.1 334 2-acylglycerol O-acyltransferase 2 [Cricetulus griseus]
GI:28974982 GenBank ERE78234.1 334 2-acylglycerol O-acyltransferase 2 [Cricetulus griseus]
GI:28974982 RefSeq NP_001102906.2 334 2-acylglycerol O-acyltransferase 2 [Rattus norvegicus]
GI:28974982 RefSeq XP_003515320.1 334 PREDICTED: 2-acylglycerol O-acyltransferase 2 [Cricetulus griseus]