Gene/Proteome Database (LMPD)

LMPD ID
LMP000581
Gene ID
51477
Species
Homo sapiens (Human)
Gene Name
inositol-3-phosphate synthase 1
Gene Symbol
ISYNA1
Synonyms
INO1; INOS; IPS; IPS 1; IPS-1
Alternate Names
inositol-3-phosphate synthase 1; MIP synthase; MI-1-P synthase; myo-inositol 1-phosphate synthase A1
Chromosome
19
Map Location
19p13.11
EC Number
5.5.1.4
Summary
This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Orthologs
View orthologs and multiple alignments for ISYNA1

Proteins

inositol-3-phosphate synthase 1 isoform 1
Refseq ID NP_057452
Protein GI 7705558
UniProt ID Q9NPH2
mRNA ID NM_016368
Length 558
RefSeq Status REVIEWED
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVFVPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT
inositol-3-phosphate synthase 1 isoform 2
Refseq ID NP_001164409
Protein GI 283135176
UniProt ID Q9NPH2
mRNA ID NM_001170938
Length 504
RefSeq Status REVIEWED
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKEANYYGSLTQAGTVSLGLDAEGQEVFVPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT
inositol-3-phosphate synthase 1 isoform 4
Refseq ID NP_001240318
Protein GI 358438328
UniProt ID Q9NPH2
mRNA ID NM_001253389
Length 430
RefSeq Status REVIEWED
MVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT

Gene Information

Entrez Gene ID
51477
Gene Name
inositol-3-phosphate synthase 1
Gene Symbol
ISYNA1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0004512 TAS:Reactome F inositol-3-phosphate synthase activity
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00562 Inositol phosphate metabolism
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150154 Inositol phosphate metabolism
REACT_150352 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR002587 Myo-inositol-1-phosphate synthase
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
inositol-3-phosphate synthase 1
Protein Entry
INO1_HUMAN
UniProt ID
Q9NPH2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NPH2-1; Sequence=Displayed; Name=2; IsoId=Q9NPH2-2; Sequence=VSP_032324; Name=3; IsoId=Q9NPH2-3; Sequence=VSP_046065; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=0.57 mM for 6-phosphate ; KM=8 uM for NAD ; pH dependence: Optimum pH is 8.0. ;
Catalytic Activity D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate.
Cofactor Name=NAD(+); Xref=ChEBI
Enzyme Regulation Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium. {ECO
Function Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
Induction By glucose and lovastain. Up-regulation is prevented by mevalonic acid, farnesol, and geranylgeraniol. Up-regulated by E2F1.
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
Sequence Caution Sequence=AAP97151.1; Type=Frameshift; Positions=82, 85, 496; Evidence= ;
Similarity Belongs to the myo-inositol 1-phosphate synthase family.
Subcellular Location Cytoplasm .
Tissue Specificity Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.

Identical and Related Proteins

Unique RefSeq proteins for LMP000581 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7705558 RefSeq NP_057452 558 inositol-3-phosphate synthase 1 isoform 1
283135176 RefSeq NP_001164409 504 inositol-3-phosphate synthase 1 isoform 2
358438328 RefSeq NP_001240318 430 inositol-3-phosphate synthase 1 isoform 4

Identical Sequences to LMP000581 proteins

Reference Database Accession Length Protein Name
GI:358438328 EMBL CAB70904.1 430 hypothetical protein [Homo sapiens]
GI:7705558 EMBL CAE90149.1 558 unnamed protein product [Homo sapiens]
GI:283135176 GenBank EAW84703.1 504 myo-inositol 1-phosphate synthase A1, isoform CRA_a [Homo sapiens]
GI:7705558 GenBank EAW84705.1 558 myo-inositol 1-phosphate synthase A1, isoform CRA_c [Homo sapiens]
GI:7705558 GenBank ABM84391.1 558 myo-inositol 1-phosphate synthase A1 [synthetic construct]
GI:7705558 GenBank ABM87335.1 558 myo-inositol 1-phosphate synthase A1, partial [synthetic construct]
GI:7705558 GenBank AIC51504.1 558 ISYNA1, partial [synthetic construct]
GI:7705558 SwissProt Q9NPH2.1 558 RecName: Full=Inositol-3-phosphate synthase 1; Short=IPS 1; AltName: Full=Myo-inositol 1-phosphate synthase; Short=MI-1-P synthase; Short=MIP synthase; Short=hIPS; AltName: Full=Myo-inositol 1-phosphate synthase A1; Short=hINO1 [Homo sapiens]

Related Sequences to LMP000581 proteins

Reference Database Accession Length Protein Name
GI:7705558 DBBJ BAA91626.1 558 unnamed protein product [Homo sapiens]
GI:283135176 DBBJ BAG52493.1 504 unnamed protein product [Homo sapiens]
GI:7705558 DBBJ BAK62261.1 558 myo-inositol 1-phosphate synthase A1 [Pan troglodytes]
GI:7705558 EMBL CAE89306.1 558 unnamed protein product [Homo sapiens]
GI:358438328 GenBank AAF26444.1 558 myo-inositol 1-phosphate synthase A1 [Homo sapiens]
GI:7705558 GenBank AAG35698.1 558 inositol 1-phosphate synthase [Homo sapiens]
GI:358438328 GenBank AAH18952.1 558 Inositol-3-phosphate synthase 1 [Homo sapiens]
GI:283135176 GenBank ABA67247.1 504 Sequence 2889 from patent US 6943241
GI:358438328 GenBank EAW84705.1 558 myo-inositol 1-phosphate synthase A1, isoform CRA_c [Homo sapiens]
GI:358438328 GenBank ABM84391.1 558 myo-inositol 1-phosphate synthase A1 [synthetic construct]
GI:358438328 GenBank ABM87335.1 558 myo-inositol 1-phosphate synthase A1, partial [synthetic construct]
GI:7705558 GenBank JAA09346.1 558 inositol-3-phosphate synthase 1 [Pan troglodytes]
GI:358438328 GenBank AIC51504.1 558 ISYNA1, partial [synthetic construct]
GI:283135176 RefSeq XP_003275877.1 505 PREDICTED: inositol-3-phosphate synthase 1 isoform 2 [Nomascus leucogenys]
GI:283135176 RefSeq XP_004060357.1 504 PREDICTED: inositol-3-phosphate synthase 1 isoform 2 [Gorilla gorilla gorilla]
GI:7705558 RefSeq NP_001267294.1 558 inositol-3-phosphate synthase 1 [Pan troglodytes]
GI:283135176 RefSeq XP_005588502.1 505 PREDICTED: inositol-3-phosphate synthase 1 isoform X2 [Macaca fascicularis]
GI:283135176 RefSeq XP_003817820.2 569 PREDICTED: inositol-3-phosphate synthase 1 isoform X2 [Pan paniscus]