Gene/Proteome Database (LMPD)

LMPD ID
LMP000583
Gene ID
27402
Species
Mus musculus (Mouse)
Gene Name
pyruvate dehydrogenase complex, component X
Gene Symbol
Pdhx
Synonyms
AI481367; E3bp; Pdx1
Alternate Names
pyruvate dehydrogenase protein X component, mitochondrial; lipoyl-containing pyruvate dehydrogenase complex component X; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX)
Chromosome
2
Map Location
2 E2|2

Proteins

pyruvate dehydrogenase protein X component, mitochondrial
Refseq ID NP_780303
Protein GI 28201978
UniProt ID Q8BKZ9
mRNA ID NM_175094
Length 501
RefSeq Status VALIDATED
MAASWRLHCNQPLLRYLLGFSSRRSLGLAQGAAAWPVDRGASWRWFHSTQLLQADPIKVLMPSLSPTMEQGNIVKWLRKEGEAVSAGDSLCEIETDKAVVTLDANDDGILAKIVVEEGAKNIQLGSLIALMVEEGEDWKQVEIPKDVSAPPPVSKPPAPTQPSPQPQIPCPARKEHKGTARFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVELKQMGKITESRPASAPPPSLSASVPPQATAGPSYPRPMTPPVSIPGQPNAAGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRRDLVKDDIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQLPSVDISVAVATDKGLITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKANLENPMRLG
transit_peptide: 1..53 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q8BKZ9.1) calculated_mol_wt: 6069 peptide sequence: MAASWRLHCNQPLLRYLLGFSSRRSLGLAQGAAAWPVDRGASWRWFHSTQLLQ mat_peptide: 54..501 product: Pyruvate dehydrogenase protein X component, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8BKZ9.1) calculated_mol_wt: 47948 peptide sequence: ADPIKVLMPSLSPTMEQGNIVKWLRKEGEAVSAGDSLCEIETDKAVVTLDANDDGILAKIVVEEGAKNIQLGSLIALMVEEGEDWKQVEIPKDVSAPPPVSKPPAPTQPSPQPQIPCPARKEHKGTARFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVELKQMGKITESRPASAPPPSLSASVPPQATAGPSYPRPMTPPVSIPGQPNAAGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRRDLVKDDIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQLPSVDISVAVATDKGLITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKANLENPMRLG

Gene Information

Entrez Gene ID
27402
Gene Name
pyruvate dehydrogenase complex, component X
Gene Symbol
Pdhx
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0016746 IEA:InterPro F transferase activity, transferring acyl groups

REACTOME Pathway Links

REACTOME Pathway ID Description
5893557 Regulation of pyruvate dehydrogenase (PDH) complex

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR004167 E3-binding domain
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase complex, component X
Protein Entry
ODPX_MOUSE
UniProt ID
Q8BKZ9
Species
Mouse

Comments

Comment Type Description
Function Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity). {ECO:0000250}.
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Part of the inner core of the multimeric pyruvate dehydrogenase complex that is composed of about 48 DLAT and 12 PDHX molecules. This core binds multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3) (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000583 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28201978 RefSeq NP_780303 501 pyruvate dehydrogenase protein X component, mitochondrial

Identical Sequences to LMP000583 proteins

Reference Database Accession Length Protein Name
GI:28201978 DBBJ BAC33120.1 501 unnamed protein product [Mus musculus]
GI:28201978 GenBank AAH61231.1 501 Pyruvate dehydrogenase complex, component X [Mus musculus]
GI:28201978 GenBank EDL27682.1 501 pyruvate dehydrogenase complex, component X [Mus musculus]
GI:28201978 SwissProt Q8BKZ9.1 501 RecName: Full=Pyruvate dehydrogenase protein X component, mitochondrial; AltName: Full=Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; AltName: Full=Lipoyl-containing pyruvate dehydrogenase complex component X; Flags: Precursor [Mus musculus]

Related Sequences to LMP000583 proteins

Reference Database Accession Length Protein Name
GI:28201978 GenBank EGV94208.1 504 Pyruvate dehydrogenase protein X component, mitochondrial [Cricetulus griseus]
GI:28201978 GenBank ERE70486.1 504 pyruvate dehydrogenase protein X component [Cricetulus griseus]
GI:28201978 RefSeq XP_005064912.1 504 PREDICTED: pyruvate dehydrogenase protein X component, mitochondrial isoform X1 [Mesocricetus auratus]
GI:28201978 RefSeq XP_005364142.1 502 PREDICTED: pyruvate dehydrogenase protein X component, mitochondrial isoform X1 [Microtus ochrogaster]
GI:28201978 RefSeq XP_006983693.1 502 PREDICTED: pyruvate dehydrogenase protein X component, mitochondrial [Peromyscus maniculatus bairdii]
GI:28201978 RefSeq XP_007617705.1 504 PREDICTED: pyruvate dehydrogenase protein X component, mitochondrial isoform X1 [Cricetulus griseus]