Gene/Proteome Database (LMPD)

LMPD ID
LMP000587
Gene ID
11041
Species
Homo sapiens (Human)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Gene Symbol
B3GNT1
Synonyms
B3GN-T1; B3GNT6; BETA3GNTI; MDDGA13; iGAT; iGNT
Alternate Names
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; poly-N-acetyllactosamine extension enzyme; i-beta-1,3-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase bGnT-6; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Chromosome
11
Map Location
11q13.2
EC Number
2.4.1.149
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for B3GNT1

Proteins

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
Refseq ID NP_006867
Protein GI 5802984
UniProt ID O43505
mRNA ID NM_006876
Length 415
RefSeq Status REVIEWED
MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC

Gene Information

Entrez Gene ID
11041
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Gene Symbol
B3GNT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0030173 NAS:UniProtKB C integral component of Golgi membrane
GO:0008532 IDA:UniProtKB F N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO:0007411 IEA:Ensembl P axon guidance
GO:0005975 TAS:Reactome P carbohydrate metabolic process
GO:0030203 TAS:Reactome P glycosaminoglycan metabolic process
GO:0018146 TAS:Reactome P keratan sulfate biosynthetic process
GO:0042339 TAS:Reactome P keratan sulfate metabolic process
GO:0030311 IDA:UniProtKB P poly-N-acetyllactosamine biosynthetic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121315 Glycosaminoglycan metabolism
REACT_121120 Keratan sulfate biosynthesis
REACT_121288 Keratan sulfate/keratin metabolism

Domain Information

InterPro Annotations

Accession Description
IPR026603 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Protein Entry
B3GN1_HUMAN
UniProt ID
O43505
Species
Human

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta- D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D- glucosaminyl-R.
Disease Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13) [MIM
Function Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. Involved in alpha- dystroglycan (DAG1) glycosylation. {ECO
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 49 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=N- acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_547";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT1";
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/b3gnt6/";

Identical and Related Proteins

Unique RefSeq proteins for LMP000587 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5802984 RefSeq NP_006867 415 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

Identical Sequences to LMP000587 proteins

Reference Database Accession Length Protein Name
GI:5802984 GenBank JAA11944.1 415 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 [Pan troglodytes]
GI:5802984 GenBank JAA29229.1 415 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 [Pan troglodytes]
GI:5802984 GenBank JAA43374.1 415 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 [Pan troglodytes]
GI:5802984 GenBank AHD78312.1 415 Sequence 26310 from patent US 8586006
GI:5802984 GenBank AIC50795.1 415 B3GNT1, partial [synthetic construct]
GI:5802984 RefSeq XP_004051629.1 415 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Gorilla gorilla gorilla]

Related Sequences to LMP000587 proteins

Reference Database Accession Length Protein Name
GI:5802984 DBBJ BAG52119.1 415 unnamed protein product [Homo sapiens]
GI:5802984 EMBL CAH93244.1 415 hypothetical protein [Pongo abelii]
GI:5802984 RefSeq NP_001126908.1 415 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Pongo abelii]
GI:5802984 RefSeq XP_003273944.1 415 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Nomascus leucogenys]
GI:5802984 RefSeq XP_003937792.1 415 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Saimiri boliviensis boliviensis]
GI:5802984 SwissProt Q5R4S2.1 415 RecName: Full=N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; AltName: Full=I-beta-1,3-N-acetylglucosaminyltransferase; Short=iGnT; AltName: Full=Poly-N-acetyllactosamine extension enzyme; AltName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 [Pongo abelii]