Gene/Proteome Database (LMPD)
LMPD ID
LMP000593
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C, beta 4
Gene Symbol
Synonyms
ARCND2; PI-PLC
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; PLC-beta-4; phosphoinositidase C; inositoltrisphosphohydrolase; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-beta-4; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))
Chromosome
20
Map Location
20p12
EC Number
3.1.4.11
Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Orthologs
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a | |
|---|---|
| Refseq ID | NP_000924 |
| Protein GI | 289547589 |
| UniProt ID | Q15147 |
| mRNA ID | NM_000933 |
| Length | 1194 |
| RefSeq Status | REVIEWED |
| MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN | |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b | |
|---|---|
| Refseq ID | NP_877949 |
| Protein GI | 289547591 |
| UniProt ID | Q15147 |
| mRNA ID | NM_182797 |
| Length | 1175 |
| RefSeq Status | REVIEWED |
| MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV | |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c | |
|---|---|
| Refseq ID | NP_001166117 |
| Protein GI | 289547594 |
| UniProt ID | Q15147 |
| mRNA ID | NM_001172646 |
| Length | 1187 |
| RefSeq Status | REVIEWED |
| MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASDDLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0030425 | IEA:Ensembl | C | dendrite |
| GO:0005634 | IEA:Ensembl | C | nucleus |
| GO:0014069 | IEA:Ensembl | C | postsynaptic density |
| GO:0005790 | IEA:Ensembl | C | smooth endoplasmic reticulum |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004629 | TAS:ProtInc | F | phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
| IPR011992 | EF-hand domain pair |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR016280 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta |
| IPR009535 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=2; IsoId=Q15147-1; Sequence=Displayed; Name=1; IsoId=Q15147-2; Sequence=VSP_004721, VSP_004722; Name=3; IsoId=Q15147-4; Sequence=VSP_037818; Note=No experimental confirmation available.; Name=4; IsoId=Q15147-5; Sequence=VSP_055182; Note=No experimental confirmation available.; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Disease | Auriculocondylar syndrome 2 (ARCND2) [MIM |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. |
| Similarity | Contains 1 C2 domain. {ECO |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
| Tissue Specificity | Preferentially expressed in the retina. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000593 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 289547589 | RefSeq | NP_000924 | 1194 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a |
| 289547591 | RefSeq | NP_877949 | 1175 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b |
| 289547594 | RefSeq | NP_001166117 | 1187 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c |
Identical Sequences to LMP000593 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:289547591 | GenBank | ADA20740.1 | 1175 | Sequence 2564 from patent US 7608413 |
| GI:289547591 | GenBank | AEN36636.1 | 1175 | Sequence 2564 from patent US 7998689 |
| GI:289547589 | GenBank | AEP61250.1 | 1194 | Sequence 344 from patent US 8026065 |
| GI:289547589 | RefSeq | XP_006723633.1 | 1194 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X10 [Homo sapiens] |
| GI:289547594 | RefSeq | XP_006723634.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X11 [Homo sapiens] |
| GI:289547591 | RefSeq | XP_006723635.1 | 1175 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X12 [Homo sapiens] |
| GI:289547591 | SwissProt | Q15147.3 | 1175 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; AltName: Full=Phosphoinositide phospholipase C-beta-4; AltName: Full=Phospholipase C-beta-4; Short=PLC-beta-4 [Homo sapiens] |
Related Sequences to LMP000593 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:289547591 | DBBJ | BAG10677.1 | 1175 | phospholipase B, delta 4, partial [synthetic construct] |
| GI:289547591 | GenBank | AAI17459.1 | 1175 | Phospholipase C, beta 4 [Homo sapiens] |
| GI:289547591 | GenBank | AAI43869.1 | 1175 | Phospholipase C, beta 4 [Homo sapiens] |
| GI:289547589 | GenBank | ADA20742.1 | 1194 | Sequence 2566 from patent US 7608413 |
| GI:289547591 | GenBank | ADA20744.1 | 1175 | Sequence 2568 from patent US 7608413 |
| GI:289547589 | GenBank | AED62137.1 | 1194 | Sequence 19 from patent US 7902154 |
| GI:289547589 | GenBank | AEN36638.1 | 1194 | Sequence 2566 from patent US 7998689 |
| GI:289547591 | GenBank | AEN36640.1 | 1175 | Sequence 2568 from patent US 7998689 |
| GI:289547589 | GenBank | AFD45203.1 | 1194 | Sequence 196 from patent US 8129114 |
| GI:289547589 | GenBank | AFD45223.1 | 1194 | Sequence 216 from patent US 8129114 |
| GI:289547589 | GenBank | AHE01057.1 | 1194 | Sequence 55436 from patent US 8586006 |
| GI:289547591 | GenBank | AHE01058.1 | 1175 | Sequence 55437 from patent US 8586006 |
| GI:289547594 | RefSeq | XP_003252648.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform 2 [Nomascus leucogenys] |
| GI:289547594 | RefSeq | XP_003810605.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4 [Pan paniscus] |
| GI:289547594 | RefSeq | XP_003933259.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [Saimiri boliviensis boliviensis] |
| GI:289547594 | RefSeq | XP_005568427.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8 [Macaca fascicularis] |
| GI:289547594 | RefSeq | XP_008016532.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [Chlorocebus sabaeus] |
| GI:289547594 | RefSeq | XP_009435053.1 | 1187 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [Pan troglodytes] |