Gene/Proteome Database (LMPD)

LMPD ID
LMP000596
Gene ID
66904
Species
Mus musculus (Mouse)
Gene Name
propionyl Coenzyme A carboxylase, beta polypeptide
Gene Symbol
Pccb
Synonyms
1300012P06Rik; AI314687; R74805
Alternate Names
propionyl-CoA carboxylase beta chain, mitochondrial; PCCase subunit beta; propanoyl-CoA:carbon dioxide ligase subunit beta
Chromosome
9
Map Location
9 E4|9
EC Number
6.4.1.3

Proteins

propionyl-CoA carboxylase beta chain, mitochondrial precursor
Refseq ID NP_080111
Protein GI 13385310
UniProt ID Q99MN9
mRNA ID NM_025835
Length 541
RefSeq Status PROVISIONAL
MAAAIRIRAVAAGARLSVLNCGLGITTRGLCSQPVSVKERIDNKRHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFMESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPEVVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREFFNFLPLSSQDPAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPSYAKNIVVGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLLGDTNYAWPTAEIAVMGAKGAVEIIFKGHQDVEAAQAEYVEKFANPFPAAVRGFVDDIIQPSSTRARICCDLEVLASKKVHRPWRKHANIPL
transit_peptide: 1..28 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q99MN9.2) calculated_mol_wt: 2826 peptide sequence: MAAAIRIRAVAAGARLSVLNCGLGITTR mat_peptide: 29..541 product: Propionyl-CoA carboxylase beta chain, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99MN9.2) calculated_mol_wt: 55601 peptide sequence: GLCSQPVSVKERIDNKRHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFMESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPEVVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREFFNFLPLSSQDPAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPSYAKNIVVGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLLGDTNYAWPTAEIAVMGAKGAVEIIFKGHQDVEAAQAEYVEKFANPFPAAVRGFVDDIIQPSSTRARICCDLEVLASKKVHRPWRKHANIPL

Gene Information

Entrez Gene ID
66904
Gene Name
propionyl Coenzyme A carboxylase, beta polypeptide
Gene Symbol
Pccb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004658 ISS:MGI F propionyl-CoA carboxylase activity
GO:0008152 ISS:GOC P metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00630 Glyoxylate and dicarboxylate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-0 isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5893521 Biotin transport and metabolism

Domain Information

InterPro Annotations

Accession Description
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR000022 Carboxyl transferase
IPR029045 ClpP/crotonase-like domain

UniProt Annotations

Entry Information

Gene Name
propionyl Coenzyme A carboxylase, beta polypeptide
Protein Entry
PCCB_MOUSE
UniProt ID
Q99MN9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA.
Pathway Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.
Similarity Belongs to the AccD/PCCB family. {ECO:0000305}.
Similarity Contains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits. {ECO:0000250}.
Tissue Specificity Broadly expressed. Most abundantly expressed in the kidney, liver, small intestine and stomach. {ECO:0000269|PubMed:11245989}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000596 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13385310 RefSeq NP_080111 541 propionyl-CoA carboxylase beta chain, mitochondrial precursor

Identical Sequences to LMP000596 proteins

Reference Database Accession Length Protein Name
GI:13385310 DBBJ BAB23712.1 541 unnamed protein product [Mus musculus]
GI:13385310 DBBJ BAC34211.1 541 unnamed protein product [Mus musculus]
GI:13385310 SwissProt Q99MN9.2 541 RecName: Full=Propionyl-CoA carboxylase beta chain, mitochondrial; Short=PCCase subunit beta; AltName: Full=Propanoyl-CoA:carbon dioxide ligase subunit beta; Flags: Precursor [Mus musculus]

Related Sequences to LMP000596 proteins

Reference Database Accession Length Protein Name
GI:13385310 GenBank AAK28525.1 541 propionyl-CoA carboxylase beta chain [Mus musculus]
GI:13385310 GenBank AAH37082.1 541 Propionyl Coenzyme A carboxylase, beta polypeptide [Mus musculus]
GI:13385310 GenBank AAH55946.1 541 Propionyl Coenzyme A carboxylase, beta polypeptide [Mus musculus]
GI:13385310 GenBank AAH26531.1 539 Pccb protein, partial [Mus musculus]
GI:13385310 GenBank EDL21035.1 541 propionyl Coenzyme A carboxylase, beta polypeptide, isoform CRA_a [Mus musculus]
GI:13385310 RefSeq NP_058726.2 541 propionyl-CoA carboxylase beta chain, mitochondrial precursor [Rattus norvegicus]