Gene/Proteome Database (LMPD)

LMPD ID
LMP000597
Gene ID
9807
Species
Homo sapiens (Human)
Gene Name
inositol hexakisphosphate kinase 1
Gene Symbol
IP6K1
Synonyms
IHPK1; PiUS
Alternate Names
inositol hexakisphosphate kinase 1; insP6 kinase 1; Pi uptake stimulator; inositol hexaphosphate kinase 1; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
Chromosome
3
Map Location
3p21.31
EC Number
2.7.4.21
Summary
This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Orthologs
View orthologs and multiple alignments for IP6K1

Proteins

inositol hexakisphosphate kinase 1 isoform 1
Refseq ID NP_695005
Protein GI 23510335
UniProt ID Q92551
mRNA ID NM_153273
Length 441
RefSeq Status REVIEWED
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
inositol hexakisphosphate kinase 1 isoform 1
Refseq ID NP_001229758
Protein GI 338827648
UniProt ID Q92551
mRNA ID NM_001242829
Length 441
RefSeq Status REVIEWED
Protein sequence is identical to GI:23510335 (mRNA isoform)
inositol hexakisphosphate kinase 1 isoform 2
Refseq ID NP_001006115
Protein GI 55769518
UniProt ID Q92551
mRNA ID NM_001006115
Length 276
RefSeq Status REVIEWED
MLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ

Gene Information

Entrez Gene ID
9807
Gene Name
inositol hexakisphosphate kinase 1
Gene Symbol
IP6K1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005730 IDA:HPA C nucleolus
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:HPA C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0046854 IDA:UniProtKB P phosphatidylinositol phosphorylation
GO:0044281 TAS:Reactome P small molecule metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6369 inositol pyrophosphates biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150154 Inositol phosphate metabolism
REACT_150275 Synthesis of IPs in the nucleus
REACT_150188 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol hexakisphosphate kinase 1
Protein Entry
IP6K1_HUMAN
UniProt ID
Q92551
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92551-1; Sequence=Displayed; Name=2; IsoId=Q92551-2; Sequence=VSP_042756;
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Sequence Caution Sequence=BAA13393.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the inositol phosphokinase (IPK) family.
Subcellular Location Cytoplasm . Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP000597 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23510335 RefSeq NP_695005 441 inositol hexakisphosphate kinase 1 isoform 1
55769518 RefSeq NP_001006115 276 inositol hexakisphosphate kinase 1 isoform 2

Identical Sequences to LMP000597 proteins

Reference Database Accession Length Protein Name
GI:23510335 DBBJ BAF82461.1 441 unnamed protein product [Homo sapiens]
GI:23510335 DBBJ BAG09681.1 441 inositol hexaphosphate kinase 1, partial [synthetic construct]
GI:55769518 DBBJ BAG58541.1 276 unnamed protein product [Homo sapiens]
GI:23510335 GenBank EAW65020.1 441 inositol hexaphosphate kinase 1, isoform CRA_a [Homo sapiens]
GI:55769518 GenBank AHD75170.1 276 Sequence 16449 from patent US 8586006
GI:23510335 GenBank AHD75171.1 441 Sequence 16450 from patent US 8586006
GI:23510335 GenBank AIC62664.1 441 IP6K1, partial [synthetic construct]
GI:23510335 RefSeq NP_001229758.1 441 inositol hexakisphosphate kinase 1 isoform 1 [Homo sapiens]
GI:55769518 RefSeq XP_004034207.1 276 PREDICTED: inositol hexakisphosphate kinase 1 isoform 2 [Gorilla gorilla gorilla]
GI:55769518 RefSeq XP_004034208.1 276 PREDICTED: inositol hexakisphosphate kinase 1 isoform 3 [Gorilla gorilla gorilla]

Related Sequences to LMP000597 proteins

Reference Database Accession Length Protein Name
GI:23510335 DBBJ BAA13393.2 462 KIAA0263 protein, partial [Homo sapiens]
GI:55769518 DBBJ BAA13393.2 462 KIAA0263 protein, partial [Homo sapiens]
GI:55769518 DBBJ BAG09681.1 441 inositol hexaphosphate kinase 1, partial [synthetic construct]
GI:55769518 GenBank AAH12944.1 441 Inositol hexakisphosphate kinase 1 [Homo sapiens]
GI:55769518 GenBank EAW65016.1 441 inositol hexaphosphate kinase 1, isoform CRA_a [Homo sapiens]
GI:55769518 GenBank EAW65018.1 441 inositol hexaphosphate kinase 1, isoform CRA_a [Homo sapiens]
GI:23510335 GenBank EHH16357.1 441 hypothetical protein EGK_11628 [Macaca mulatta]
GI:55769518 RefSeq NP_695005.1 441 inositol hexakisphosphate kinase 1 isoform 1 [Homo sapiens]
GI:23510335 RefSeq XP_003257126.1 441 PREDICTED: inositol hexakisphosphate kinase 1 [Nomascus leucogenys]
GI:23510335 RefSeq XP_001166017.2 441 PREDICTED: inositol hexakisphosphate kinase 1 [Pan troglodytes]
GI:23510335 RefSeq XP_008970500.1 441 PREDICTED: inositol hexakisphosphate kinase 1 [Pan paniscus]
GI:23510335 RefSeq XP_008970501.1 441 PREDICTED: inositol hexakisphosphate kinase 1 [Pan paniscus]