Gene/Proteome Database (LMPD)

LMPD ID
LMP000602
Gene ID
5241
Species
Homo sapiens (Human)
Gene Name
progesterone receptor
Gene Symbol
PGR
Synonyms
NR3C3; PR
Alternate Names
progesterone receptor; nuclear receptor subfamily 3 group C member 3
Chromosome
11
Map Location
11q22-q23
Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
Orthologs
View orthologs and multiple alignments for PGR

Proteins

progesterone receptor isoform A
Refseq ID NP_001189403
Protein GI 110611914
UniProt ID P06401
mRNA ID NM_001202474
Length 933
RefSeq Status REVIEWED
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
progesterone receptor isoform B
Refseq ID NP_000917
Protein GI 110611914
UniProt ID P06401
mRNA ID NM_000926
Length 933
RefSeq Status REVIEWED
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
progesterone receptor isoform C
Refseq ID NP_001258090
Protein GI 110611914
UniProt ID P06401
mRNA ID NM_001271161
Length 933
RefSeq Status REVIEWED
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
progesterone receptor isoform D
Refseq ID NP_001258091
Protein GI 403054812
UniProt ID P06401
mRNA ID NM_001271162
Length 339
RefSeq Status REVIEWED
MEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK

Gene Information

Entrez Gene ID
5241
Gene Name
progesterone receptor
Gene Symbol
PGR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005654 TAS:Reactome C nucleoplasm
GO:0003677 TAS:ProtInc F DNA binding
GO:0000978 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0019899 IPI:UniProtKB F enzyme binding
GO:0004879 IEA:Ensembl F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102 IPI:UniProtKB F receptor binding
GO:0005496 IEA:UniProtKB-KW F steroid binding
GO:0003707 TAS:ProtInc F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007267 TAS:ProtInc P cell-cell signaling
GO:0002070 IEA:Ensembl P epithelial cell maturation
GO:0010467 TAS:Reactome P gene expression
GO:0010629 IEP:UniProtKB P negative regulation of gene expression
GO:0001542 IEA:Ensembl P ovulation from ovarian follicle
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0050847 IEA:Ensembl P progesterone receptor signaling pathway
GO:0050678 IEA:Ensembl P regulation of epithelial cell proliferation
GO:0007165 TAS:ProtInc P signal transduction
GO:0060748 IEA:Ensembl P tertiary branching involved in mammary gland duct morphogenesis
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter

KEGG Pathway Links

KEGG Pathway ID Description
hsa04114 Oocyte meiosis
hsa04914 Progesterone-mediated oocyte maturation

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR000128 Progesterone receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
progesterone receptor
Protein Entry
PRGR_HUMAN
UniProt ID
P06401
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=B; IsoId=P06401-1; Sequence=Displayed; Name=A; IsoId=P06401-2; Sequence=VSP_003706; Name=3; IsoId=P06401-3; Sequence=VSP_046942; Name=4; Synonyms=PR-M; IsoId=P06401-4; Sequence=VSP_047454, VSP_047455; Name=5; Synonyms=delta4; IsoId=P06401-5; Sequence=VSP_053543;
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Function Isoform A
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Interaction Q9H467:CUEDC2; NbExp=9; IntAct=EBI-78539, EBI-1248228; P40763:STAT3; NbExp=3; IntAct=EBI-78539, EBI-518675;
Ptm Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.
Ptm Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1. {ECO
Ptm Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294. {ECO
Ptm Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294. {ECO
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Isoform 4: Mitochondrion outer membrane .
Subcellular Location Isoform A
Subcellular Location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.
Subunit Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. {ECO
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pgr/";
Web Resource Name=Wikipedia; Note=Progesterone receptor entry; URL="http://en.wikipedia.org/wiki/Progesterone_receptor";

Identical and Related Proteins

Unique RefSeq proteins for LMP000602 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110611914 RefSeq NP_001189403 933 progesterone receptor isoform A
110611914 RefSeq NP_000917 933 progesterone receptor isoform B
110611914 RefSeq NP_001258090 933 progesterone receptor isoform C
403054812 RefSeq NP_001258091 339 progesterone receptor isoform D

Identical Sequences to LMP000602 proteins

Reference Database Accession Length Protein Name
GI:403054812 DBBJ BAG65592.1 339 unnamed protein product [Homo sapiens]
GI:110611914 DBBJ BAJ17870.1 933 progesterone receptor, partial [synthetic construct]
GI:110611914 DBBJ BAJ17870.1 933 progesterone receptor, partial [synthetic construct]
GI:110611914 DBBJ BAJ17870.1 933 progesterone receptor, partial [synthetic construct]
GI:110611914 EMBL CAX21628.1 933 unnamed protein product [synthetic construct]
GI:110611914 EMBL CAX21628.1 933 unnamed protein product [synthetic construct]
GI:110611914 EMBL CAX21628.1 933 unnamed protein product [synthetic construct]
GI:110611914 GenBank EAW67000.1 933 progesterone receptor, isoform CRA_d [Homo sapiens]
GI:110611914 GenBank EAW67000.1 933 progesterone receptor, isoform CRA_d [Homo sapiens]
GI:110611914 GenBank EAW67000.1 933 progesterone receptor, isoform CRA_d [Homo sapiens]
GI:110611914 GenBank AAI52915.1 933 Progesterone receptor, partial [synthetic construct]
GI:110611914 GenBank AAI52915.1 933 Progesterone receptor, partial [synthetic construct]
GI:110611914 GenBank AAI52915.1 933 Progesterone receptor, partial [synthetic construct]
GI:110611914 GenBank AFQ84299.1 933 Sequence 5 from patent US 8252532
GI:110611914 GenBank AFQ84299.1 933 Sequence 5 from patent US 8252532
GI:110611914 GenBank AFQ84299.1 933 Sequence 5 from patent US 8252532
GI:110611914 SwissProt P06401.4 933 RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3 [Homo sapiens]
GI:110611914 SwissProt P06401.4 933 RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3 [Homo sapiens]
GI:110611914 SwissProt P06401.4 933 RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3 [Homo sapiens]

Related Sequences to LMP000602 proteins

Reference Database Accession Length Protein Name
GI:110611914 EMBL CAA36018.1 933 unnamed protein product [Homo sapiens]
GI:110611914 EMBL CAA36018.1 933 unnamed protein product [Homo sapiens]
GI:110611914 EMBL CAA36018.1 933 unnamed protein product [Homo sapiens]
GI:403054812 EMBL CAD22448.1 933 unnamed protein product [Homo sapiens]
GI:403054812 EMBL CAD22956.1 933 unnamed protein product [Homo sapiens]
GI:403054812 EMBL CAX21628.1 933 unnamed protein product [synthetic construct]
GI:110611914 GenBank AAD01587.1 933 progesterone receptor [Homo sapiens]
GI:110611914 GenBank AAD01587.1 933 progesterone receptor [Homo sapiens]
GI:110611914 GenBank AAD01587.1 933 progesterone receptor [Homo sapiens]
GI:110611914 GenBank AAE72578.1 933 Sequence 14 from patent US 6236946
GI:110611914 GenBank AAE72578.1 933 Sequence 14 from patent US 6236946
GI:110611914 GenBank AAE72578.1 933 Sequence 14 from patent US 6236946
GI:403054812 GenBank AAS00096.1 933 progesterone receptor [Homo sapiens]
GI:110611914 GenBank ACP74277.1 933 Sequence 4 from patent US 7496489
GI:110611914 GenBank ACP74277.1 933 Sequence 4 from patent US 7496489
GI:110611914 GenBank ACP74277.1 933 Sequence 4 from patent US 7496489
GI:403054812 GenBank AFQ84299.1 933 Sequence 5 from patent US 8252532
GI:110611914 GenBank AGV91519.1 933 Sequence 75 from patent US 8530168
GI:110611914 GenBank AGV91519.1 933 Sequence 75 from patent US 8530168
GI:110611914 GenBank AGV91519.1 933 Sequence 75 from patent US 8530168
GI:110611914 GenBank AHD78597.1 933 Sequence 26595 from patent US 8586006
GI:110611914 GenBank AHD78597.1 933 Sequence 26595 from patent US 8586006
GI:110611914 GenBank AHD78597.1 933 Sequence 26595 from patent US 8586006
GI:403054812 SwissProt P06401.4 933 RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3 [Homo sapiens]