Gene/Proteome Database (LMPD)
LMPD ID
LMP000607
Gene ID
Species
Mus musculus (Mouse)
Gene Name
microsomal triglyceride transfer protein
Gene Symbol
Synonyms
1810043K16Rik; MTP
Alternate Names
microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein B; microsomal triglyceride transfer protein, large subunit
Chromosome
3
Map Location
3 G3|3 64.06 cM
Proteins
| microsomal triglyceride transfer protein large subunit isoform 1 precursor | |
|---|---|
| Refseq ID | NP_001156929 |
| Protein GI | 254540023 |
| UniProt ID | O08601 |
| mRNA ID | NM_001163457 |
| Length | 909 |
| RefSeq Status | VALIDATED |
| MTVVMGKCQVSDGRQLLLFYAVLLLFPTLCAMQNSGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF | |
| microsomal triglyceride transfer protein large subunit isoform 2 precursor | |
|---|---|
| Refseq ID | NP_032668 |
| Protein GI | 254540223 |
| UniProt ID | O08601 |
| mRNA ID | NM_008642 |
| Length | 894 |
| RefSeq Status | VALIDATED |
| MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF | |
| sig_peptide: 1..32 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3562 peptide sequence: MTVVMGKCQVSDGRQLLLFYAVLLLFPTLCAM sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2297 peptide sequence: MILLAVLFLCFFSSYSASVKG mat_peptide: 22..894 product: Microsomal triglyceride transfer protein large subunit experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O08601.2) calculated_mol_wt: 96821 peptide sequence: HTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF | |
Gene Information
Entrez Gene ID
Gene Name
microsomal triglyceride transfer protein
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:MGI | C | Golgi apparatus |
| GO:0016323 | IEA:Ensembl | C | basolateral plasma membrane |
| GO:0031526 | IEA:Ensembl | C | brush border membrane |
| GO:0005783 | IDA:MGI | C | endoplasmic reticulum |
| GO:0031988 | IEA:Ensembl | C | membrane-bounded vesicle |
| GO:0031528 | IEA:Ensembl | C | microvillus membrane |
| GO:0043235 | ISO:MGI | C | receptor complex |
| GO:0005791 | IEA:Ensembl | C | rough endoplasmic reticulum |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0005319 | IDA:MGI | F | lipid transporter activity |
| GO:0042632 | IMP:MGI | P | cholesterol homeostasis |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0006629 | IDA:MGI | P | lipid metabolic process |
| GO:0042157 | IMP:MGI | P | lipoprotein metabolic process |
| GO:0042953 | IDA:MGI | P | lipoprotein transport |
| GO:0006497 | IDA:MGI | P | protein lipidation |
| GO:0051592 | IEA:Ensembl | P | response to calcium ion |
| GO:0006641 | IDA:MGI | P | triglyceride metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04975 | Fat digestion and absorption |
| mmu04975 | Fat digestion and absorption |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5893389 | Chylomicron-mediated lipid transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
microsomal triglyceride transfer protein
Protein Entry
MTP_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=MTP-A; IsoId=O08601-1; Sequence=Displayed; Name=2; Synonyms=MTPv1, MTP-B; IsoId=O08601-2; Sequence=VSP_038546; Note=Cleaved by signal peptidase between residues Gln-33 and Asn-34 (PubMed:17312007 and PubMed:17635917).; |
| Developmental Stage | Expression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post-coitum (E9.5). Intestinal expression is detected around E12.5 and attains full adult expression patterns by E14.5. {ECO:0000269|PubMed:10744773}. |
| Disruption Phenotype | Lowers plasma and tissue triglyceride levels, and increases cellular free cholesterol. {ECO:0000269|PubMed:10713055, ECO:0000269|PubMed:18502767}. |
| Function | Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. {ECO:0000269|PubMed:17312007, ECO:0000269|PubMed:17635917, ECO:0000269|PubMed:18502767}. |
| Induction | Up-regulated by FOXO1. {ECO:0000269|PubMed:18497885}. |
| Similarity | Contains 1 vitellogenin domain. {ECO:0000255|PROSITE- ProRule:PRU00557}. |
| Subcellular Location | Isoform 1: Endoplasmic reticulum. Note=Localized to the endoplasmic reticulum according to PubMed:17312007. |
| Subcellular Location | Isoform 2: Endoplasmic reticulum. Golgi apparatus. Note=Localized to the endoplasmic reticulum according to PubMed:17312007. Localized to the Golgi apparatus according to PubMed:17635917. |
| Subunit | Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI). |
| Tissue Specificity | Expressed in heart. Isoform 1 is mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells. Isoform 2 is ubiquitous, and is the major isoform in hematopoietic cells and adipocytes. {ECO:0000269|PubMed:17312007, ECO:0000269|PubMed:17635917, ECO:0000269|PubMed:9502759}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000607 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 254540023 | RefSeq | NP_001156929 | 909 | microsomal triglyceride transfer protein large subunit isoform 1 precursor |
| 254540223 | RefSeq | NP_032668 | 894 | microsomal triglyceride transfer protein large subunit isoform 2 precursor |
Identical Sequences to LMP000607 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:254540223 | DBBJ | BAE27255.1 | 894 | unnamed protein product [Mus musculus] |
| GI:254540023 | RefSeq | XP_006501165.1 | 909 | PREDICTED: microsomal triglyceride transfer protein large subunit isoform X1 [Mus musculus] |
| GI:254540223 | RefSeq | XP_006501166.1 | 894 | PREDICTED: microsomal triglyceride transfer protein large subunit isoform X2 [Mus musculus] |
| GI:254540223 | SwissProt | O08601.2 | 894 | RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor [Mus musculus] |
Related Sequences to LMP000607 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:254540023 | DBBJ | BAE27255.1 | 894 | unnamed protein product [Mus musculus] |
| GI:254540223 | GenBank | AAB51431.1 | 894 | microsomal triglyceride transfer protein [Mus musculus] |
| GI:254540223 | GenBank | AAH12686.1 | 894 | Microsomal triglyceride transfer protein [Mus musculus] |
| GI:254540023 | GenBank | EDL12110.1 | 894 | microsomal triglyceride transfer protein [Mus musculus] |
| GI:254540223 | GenBank | EDL12110.1 | 894 | microsomal triglyceride transfer protein [Mus musculus] |
| GI:254540223 | GenBank | ACB41497.1 | 909 | microsomal triglyceride transfer protein B [Mus musculus] |
| GI:254540023 | GenBank | ACB41497.1 | 909 | microsomal triglyceride transfer protein B [Mus musculus] |
| GI:254540223 | RefSeq | NP_001156929.1 | 909 | microsomal triglyceride transfer protein large subunit isoform 1 precursor [Mus musculus] |
| GI:254540023 | RefSeq | NP_032668.2 | 894 | microsomal triglyceride transfer protein large subunit isoform 2 precursor [Mus musculus] |
| GI:254540223 | RefSeq | XP_006501165.1 | 909 | PREDICTED: microsomal triglyceride transfer protein large subunit isoform X1 [Mus musculus] |
| GI:254540023 | RefSeq | XP_006501166.1 | 894 | PREDICTED: microsomal triglyceride transfer protein large subunit isoform X2 [Mus musculus] |
| GI:254540023 | SwissProt | O08601.2 | 894 | RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor [Mus musculus] |