Gene/Proteome Database (LMPD)

LMPD ID
LMP000610
Gene ID
12409
Species
Mus musculus (Mouse)
Gene Name
carbonyl reductase 2
Gene Symbol
Cbr2
Synonyms
MLCR
Alternate Names
carbonyl reductase [NADPH] 2; LCR; AP27; adipocyte protein P27; lung carbonyl reductase; NADPH-dependent carbonyl reductase 2
Chromosome
11
Map Location
11 E2|11 84.47 cM
EC Number
1.1.1.184

Proteins

carbonyl reductase [NADPH] 2
Refseq ID NP_031647
Protein GI 6671688
UniProt ID P08074
mRNA ID NM_007621
Length 244
RefSeq Status VALIDATED
MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSDRSASTSGGGILVDAGYLAS

Gene Information

Entrez Gene ID
12409
Gene Name
carbonyl reductase 2
Gene Symbol
Cbr2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0004090 IDA:MGI F carbonyl reductase (NADPH) activity
GO:0043621 IDA:MGI F protein self-association
GO:0006116 TAS:MGI P NADH oxidation
GO:0051262 IDA:MGI P protein tetramerization

KEGG Pathway Links

KEGG Pathway ID Description
mmu00590 Arachidonic acid metabolism
mmu01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
mmu00980 Metabolism of xenobiotics by cytochrome P450

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
carbonyl reductase 2
Protein Entry
CBR2_MOUSE
UniProt ID
P08074
Species
Mouse

Comments

Comment Type Description
Catalytic Activity R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
Function May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism. {ECO:0000269|PubMed:7705352}.
Induction By glucocorticoids. Activated by fatty acids.
Miscellaneous Uses both NADP and NAD as substrates. Has a strong preference for NADP.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:8040004}.
Subunit Homotetramer. {ECO:0000269|PubMed:8805511}.
Tissue Specificity Lung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in adipose tissue > testis = heart > kidney = spleen > brain = liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP000610 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6671688 RefSeq NP_031647 244 carbonyl reductase [NADPH] 2

Identical Sequences to LMP000610 proteins

Reference Database Accession Length Protein Name
GI:6671688 GenBank EDL34801.1 244 carbonyl reductase 2, isoform CRA_b [Mus musculus]
GI:6671688 GenBank AEQ84534.1 244 Sequence 27 from patent US 8039587
GI:6671688 GenBank AEU53397.1 244 Sequence 27 from patent US 8062891
GI:6671688 GenBank AGO72350.1 244 Sequence 27 from patent US 8470972
GI:6671688 GenBank AGU32341.1 244 Sequence 27 from patent US 8507277
GI:6671688 GenBank AGX48245.1 244 Sequence 27 from patent US 8541550

Related Sequences to LMP000610 proteins

Reference Database Accession Length Protein Name
GI:6671688 GenBank EDM06895.1 244 rCG34484, isoform CRA_a [Rattus norvegicus]
GI:6671688 RefSeq XP_001081815.2 244 PREDICTED: carbonyl reductase [NADPH] 2 [Rattus norvegicus]
GI:6671688 RefSeq XP_003751035.1 244 PREDICTED: carbonyl reductase [NADPH] 2 [Rattus norvegicus]
GI:6671688 RefSeq XP_005350953.1 244 PREDICTED: carbonyl reductase [NADPH] 2-like [Microtus ochrogaster]
GI:6671688 RefSeq XP_006061845.1 244 PREDICTED: carbonyl reductase [NADPH] 2-like [Bubalus bubalis]
GI:6671688 RefSeq XP_008826490.1 244 PREDICTED: carbonyl reductase [NADPH] 2 [Nannospalax galili]