Gene/Proteome Database (LMPD)

LMPD ID
LMP000612
Gene ID
8436
Species
Homo sapiens (Human)
Gene Name
serum deprivation response
Gene Symbol
SDPR
Synonyms
CAVIN2; PS-p68; SDR; cavin-2
Chromosome
2
Map Location
2q32-q33
Summary
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Orthologs
View orthologs and multiple alignments for SDPR

Proteins

serum deprivation-response protein
Refseq ID NP_004648
Protein GI 4759082
UniProt ID O95810
mRNA ID NM_004657
Length 425
RefSeq Status REVIEWED
MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQVHQTS

Gene Information

Entrez Gene ID
8436
Gene Name
serum deprivation response
Gene Symbol
SDPR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0001786 IDA:UniProtKB F phosphatidylserine binding
GO:0005543 TAS:ProtInc F phospholipid binding

Domain Information

InterPro Annotations

Accession Description
IPR026752 Cavin family

UniProt Annotations

Entry Information

Gene Name
serum deprivation response
Protein Entry
O95810_HUMAN
UniProt ID
O95810
Species
Human

Comments

Comment Type Description
Function May play a role in targeting PRKCA to caveolae.
Induction Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.
Interaction P08567:PLEK; NbExp=4; IntAct=EBI-742141, EBI-2565501;
Miscellaneous Binds phosphatidylserine (PS) in a calcium- independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.
Ptm Phosphorylated on Ser residues. {ECO
Similarity Belongs to the PTRF/SDPR family.
Subcellular Location Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae.
Subunit Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC. {ECO
Tissue Specificity Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP000612 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4759082 RefSeq NP_004648 425 serum deprivation-response protein

Identical Sequences to LMP000612 proteins

Reference Database Accession Length Protein Name
GI:4759082 DBBJ BAJ20413.1 425 serum deprivation response, partial [synthetic construct]
GI:4759082 GenBank EAX10833.1 425 serum deprivation response (phosphatidylserine binding protein) [Homo sapiens]
GI:4759082 GenBank ABM82366.1 425 serum deprivation response (phosphatidylserine binding protein) [synthetic construct]
GI:4759082 GenBank ABM85543.1 425 serum deprivation response (phosphatidylserine binding protein), partial [synthetic construct]
GI:4759082 GenBank ADR96981.1 425 Sequence 418 from patent US 7749695
GI:4759082 GenBank AHD69938.1 425 Sequence 1527 from patent US 8586006

Related Sequences to LMP000612 proteins

Reference Database Accession Length Protein Name
GI:4759082 DBBJ BAF83067.1 425 unnamed protein product [Homo sapiens]
GI:4759082 GenBank JAA01016.1 425 serum deprivation response [Pan troglodytes]
GI:4759082 GenBank JAA19710.1 425 serum deprivation response [Pan troglodytes]
GI:4759082 GenBank JAA28077.1 425 serum deprivation response [Pan troglodytes]
GI:4759082 GenBank JAA39791.1 425 serum deprivation response [Pan troglodytes]
GI:4759082 RefSeq XP_001167854.1 425 PREDICTED: serum deprivation-response protein [Pan troglodytes]