Gene/Proteome Database (LMPD)

LMPD ID
LMP000614
Gene ID
271424
Species
Mus musculus (Mouse)
Gene Name
inositol hexaphosphate kinase 3
Gene Symbol
Ip6k3
Synonyms
D830007E07Rik; Ihpk3
Alternate Names
inositol hexakisphosphate kinase 3; insP6 kinase 3
Chromosome
17
Map Location
17 A3.3|17
EC Number
2.7.4.21

Proteins

inositol hexakisphosphate kinase 3
Refseq ID NP_766615
Protein GI 27370542
UniProt ID Q8BWD2
mRNA ID NM_173027
Length 396
RefSeq Status PROVISIONAL
MVVRHSSDKGKIGVGVPLEPFLHQVGGHLSVLQYDAYTVCKPLVSQEQKFYESLPLAMKCFTPKYKGTITVRLRRDSRGHLGLVANPLKENLEPFQVSPESRAVALWQTLQQTTGSESSPCPLTQLARSLKESAAKVLLRSDCHLSTQASPLVESEDGSQVERKGFNPWGLHCHQAHLTRLCSQYPEDKRHRFLLLENVVSQYKQPCILDLKMGTRQHGDDASEEKKARHMKKCAQSTSACLGVRICGMQVYQTDQKSFLCKDKYYGRKLSVEGFRQALSQFLHDGTRLRAELLEPILRRLQALLTVIRSQSSYRFYSSSVLIIYDGEPPQTTQGSTSGGVTSGDPAKVDVRMIDFAHTTFKGSWNEHTTYEGPDPGYIFGLENLIGILRDIQEGE

Gene Information

Entrez Gene ID
271424
Gene Name
inositol hexaphosphate kinase 3
Gene Symbol
Ip6k3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IDA:UniProtKB C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0000831 IEA:Ensembl F inositol hexakisphosphate 6-kinase activity
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0032958 IEA:Ensembl P inositol phosphate biosynthetic process
GO:0046488 IEA:Ensembl P phosphatidylinositol metabolic process
GO:0006468 IEA:Ensembl P protein phosphorylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5892760 Metabolism
5894029 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol hexaphosphate kinase 3
Protein Entry
IP6K3_MOUSE
UniProt ID
Q8BWD2
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). {ECO:0000250}.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Highly expressed in cerebellum, brain cortex, kidney, thymus and lung. Detected at lower levels in hippocampus, testis, heart and olfactory bulb. {ECO:0000269|PubMed:11502751}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000614 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27370542 RefSeq NP_766615 396 inositol hexakisphosphate kinase 3

Identical Sequences to LMP000614 proteins

Reference Database Accession Length Protein Name
GI:27370542 DBBJ BAC35176.1 396 unnamed protein product [Mus musculus]
GI:27370542 SwissProt Q8BWD2.1 396 RecName: Full=Inositol hexakisphosphate kinase 3; Short=InsP6 kinase 3; AltName: Full=Inositol hexaphosphate kinase 3 [Mus musculus]

Related Sequences to LMP000614 proteins

Reference Database Accession Length Protein Name
GI:27370542 GenBank EDL22533.1 464 inositol hexaphosphate kinase 3, isoform CRA_a, partial [Mus musculus]
GI:27370542 GenBank EDL22534.1 399 inositol hexaphosphate kinase 3, isoform CRA_b [Mus musculus]
GI:27370542 GenBank AAI41264.1 396 Inositol hexaphosphate kinase 3 [Mus musculus]
GI:27370542 RefSeq XP_006996650.1 396 PREDICTED: inositol hexakisphosphate kinase 3 isoform X2 [Peromyscus maniculatus bairdii]
GI:27370542 RefSeq XP_006996651.1 396 PREDICTED: inositol hexakisphosphate kinase 3 isoform X3 [Peromyscus maniculatus bairdii]
GI:27370542 RefSeq XP_008771000.1 401 PREDICTED: inositol hexakisphosphate kinase 3 isoform X2 [Rattus norvegicus]