Gene/Proteome Database (LMPD)

LMPD ID
LMP000616
Gene ID
170835
Species
Mus musculus (Mouse)
Gene Name
inositol polyphosphate 5-phosphatase J
Gene Symbol
Inpp5j
Synonyms
Pib5pa; Pipp
Alternate Names
phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; proline-rich inositol polyphosphate 5-phosphatase; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A
Chromosome
11
Map Location
11 A1|11
EC Number
3.1.3.56

Proteins

phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Refseq ID NP_766027
Protein GI 262231799
UniProt ID P59644
mRNA ID NM_172439
Length 1003
RefSeq Status VALIDATED
MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLPAKNSGPASSEPRLTLAPVGPRAAVSPPSERPRLVLSSPRPVLAPLSIAGEQKRPPPPHSSNRAAKSVGQLVVSAAAASKPPPVASVSILAPKSLGQLVISASAMPRPSPAPLGSVLTPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQEGHLAAASVTSTPASERQLPARQKDTAVPRPTPPADKCLYTPERAAGPATSPPRAQAFSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSPGLPESGTRSPGLLSPTFRPGIPSSQTVPPPLPKPPRSPSRSPSRSPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDNDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALHPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSSSRGSSEEGPSGLPGPWAFPPSVPRSLGLLPALRLETVDPGGGGSWGADQEAPDPNSLSPSPQGRLGLEEGGLGP

Gene Information

Entrez Gene ID
170835
Gene Name
inositol polyphosphate 5-phosphatase J
Gene Symbol
Inpp5j
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISO:MGI C cytoplasm
GO:0043198 IDA:MGI C dendritic shaft
GO:0030426 IDA:MGI C growth cone
GO:0005886 IDA:MGI C plasma membrane
GO:0001726 ISO:MGI C ruffle
GO:0052659 IEA:UniProtKB-EC F inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052658 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445 IEA:UniProtKB-EC F inositol-polyphosphate 5-phosphatase activity
GO:0034485 IDA:MGI F phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0031115 IEA:Ensembl P negative regulation of microtubule polymerization
GO:0010977 IDA:MGI P negative regulation of neuron projection development
GO:0033137 IDA:MGI P negative regulation of peptidyl-serine phosphorylation
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5894027 Synthesis of IP2, IP, and Ins in the cytosol
5894009 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate 5-phosphatase J
Protein Entry
PI5PA_MOUSE
UniProt ID
P59644
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Catalytic Activity D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
Domain The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.
Function Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12536145}. Note=Predominantly localized to membrane ruffles.

Identical and Related Proteins

Unique RefSeq proteins for LMP000616 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
262231799 RefSeq NP_766027 1003 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Identical Sequences to LMP000616 proteins

Reference Database Accession Length Protein Name
GI:262231799 DBBJ BAE41572.1 1003 unnamed protein product [Mus musculus]
GI:262231799 GenBank AAI31635.1 1003 Inositol polyphosphate 5-phosphatase J [Mus musculus]
GI:262231799 GenBank AAI31636.1 1003 Inositol polyphosphate 5-phosphatase J [Mus musculus]
GI:262231799 GenBank EDL40427.1 1003 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_b [Mus musculus]
GI:262231799 RefSeq XP_006514616.1 1003 PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1 [Mus musculus]
GI:262231799 SwissProt P59644.2 1003 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; AltName: Full=Inositol polyphosphate 5-phosphatase J [Mus musculus]

Related Sequences to LMP000616 proteins

Reference Database Accession Length Protein Name
GI:262231799 DBBJ BAA90553.1 1001 proline-rich inositol polyphosphate 5-phosphatase [Rattus norvegicus]
GI:262231799 DBBJ BAC28654.1 1003 unnamed protein product [Mus musculus]
GI:262231799 DBBJ BAE42196.1 1003 unnamed protein product [Mus musculus]
GI:262231799 GenBank ABA09102.1 1001 Sequence 3 from patent US 6908743
GI:262231799 GenBank EDM00181.1 1001 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A [Rattus norvegicus]
GI:262231799 RefSeq NP_598246.1 1001 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A [Rattus norvegicus]