Gene/Proteome Database (LMPD)

LMPD ID
LMP000625
Gene ID
302
Species
Homo sapiens (Human)
Gene Name
annexin A2
Gene Symbol
ANXA2
Synonyms
ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV
Alternate Names
annexin A2; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; calpactin I heavy polypeptide; placental anticoagulant protein IV; epididymis secretory protein Li 270
Chromosome
15
Map Location
15q22.2
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ANXA2

Proteins

annexin A2 isoform 1
Refseq ID NP_001002858
Protein GI 50845388
UniProt ID P07355
mRNA ID NM_001002858
Length 357
RefSeq Status REVIEWED
MGRQLAGCGDAGKKASFKMSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
annexin A2 isoform 2
Refseq ID NP_001129487
Protein GI 209862831
UniProt ID P07355
mRNA ID NM_001136015
Length 339
RefSeq Status REVIEWED
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
annexin A2 isoform 2
Refseq ID NP_001002857
Protein GI 50845386
UniProt ID P07355
mRNA ID NM_001002857
Length 339
RefSeq Status REVIEWED
Protein sequence is identical to GI:209862831 (mRNA isoform)
annexin A2 isoform 2
Refseq ID NP_004030
Protein GI 4757756
UniProt ID P07355
mRNA ID NM_004039
Length 339
RefSeq Status REVIEWED
Protein sequence is identical to GI:209862831 (mRNA isoform)

Gene Information

Entrez Gene ID
302
Gene Name
annexin A2
Gene Symbol
ANXA2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0005604 IEA:UniProtKB-KW C basement membrane
GO:0005938 IEA:Ensembl C cell cortex
GO:0009986 IDA:UniProt C cell surface
GO:0005769 IEA:Ensembl C early endosome
GO:0005768 IDA:UniProtKB C endosome
GO:0005615 IDA:UniProt C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0019897 IEA:Ensembl C extrinsic component of plasma membrane
GO:0031902 IDA:UniProt C late endosome membrane
GO:0005811 IDA:UniProtKB C lipid particle
GO:0005765 IDA:UniProt C lysosomal membrane
GO:0044354 IEA:Ensembl C macropinosome
GO:0016020 IDA:UniProtKB C membrane
GO:0030496 IDA:UniProtKB C midbody
GO:0035749 IEA:Ensembl C myelin sheath adaxonal region
GO:0005634 IDA:UniProt C nucleus
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0005886 IDA:BHF-UCL C plasma membrane
GO:0043234 IEA:Ensembl C protein complex
GO:0001726 IEA:Ensembl C ruffle
GO:0042383 IEA:Ensembl C sarcolemma
GO:0031982 IDA:UniProtKB C vesicle
GO:0044548 IPI:UniProt F S100 protein binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005544 IDA:UniProtKB F calcium-dependent phospholipid binding
GO:0048306 IPI:AgBase F calcium-dependent protein binding
GO:0005546 IMP:UniProt F phosphatidylinositol-4,5-bisphosphate binding
GO:0019834 IDA:UniProt F phospholipase A2 inhibitor activity
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0001525 IEP:UniProtKB P angiogenesis
GO:0007589 IEA:Ensembl P body fluid secretion
GO:0071229 IEA:Ensembl P cellular response to acid chemical
GO:0030199 IEA:Ensembl P collagen fibril organization
GO:0042730 IEA:Ensembl P fibrinolysis
GO:0006900 IMP:UniProt P membrane budding
GO:0001765 IMP:UniProt P membrane raft assembly
GO:0043086 IDA:GOC P negative regulation of catalytic activity
GO:0036035 IDA:UniProt P osteoclast development
GO:0051099 IEA:Ensembl P positive regulation of binding
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0031340 IDA:UniProtKB P positive regulation of vesicle fusion
GO:0051290 IDA:UniProt P protein heterotetramerization
GO:0072661 IEA:Ensembl P protein targeting to plasma membrane

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_641 Dissolution of Fibrin Clot
REACT_604 Hemostasis

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR002389 Annexin, type II
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A2
Protein Entry
ANXA2_HUMAN
UniProt ID
P07355
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07355-1; Sequence=Displayed; Name=2; IsoId=P07355-2; Sequence=VSP_038091;
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
Interaction Q99IB8:- (xeno); NbExp=5; IntAct=EBI-352622, EBI-6927873; P40692:MLH1; NbExp=7; IntAct=EBI-352622, EBI-744248; Q8NBP7:PCSK9; NbExp=7; IntAct=EBI-352622, EBI-7539251;
Miscellaneous It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Ptm ISGylated.
Ptm Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. {ECO
Sequence Caution Sequence=AAH66955.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the annexin family.
Similarity Contains 4 annexin repeats.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Subunit Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). Interacts with COCH. {ECO
Web Resource Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";

Identical and Related Proteins

Unique RefSeq proteins for LMP000625 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50845388 RefSeq NP_001002858 357 annexin A2 isoform 1
209862831 RefSeq NP_001129487 339 annexin A2 isoform 2

Identical Sequences to LMP000625 proteins

Reference Database Accession Length Protein Name
GI:50845388 GenBank ADT46467.1 357 Sequence 128 from patent US 7842466
GI:50845388 GenBank AEN34213.1 357 Sequence 141 from patent US 7998689
GI:50845388 GenBank AEN34214.1 357 Sequence 142 from patent US 7998689
GI:50845388 GenBank AHD74453.1 357 Sequence 14470 from patent US 8586006
GI:50845388 GenBank AHE18760.1 357 Sequence 91 from patent US 8614309
GI:50845388 RefSeq XP_004056333.1 357 PREDICTED: annexin A2-like isoform 3 [Gorilla gorilla gorilla]
GI:209862831 RefSeq XP_008951484.1 339 PREDICTED: annexin A2 [Pan paniscus]
GI:209862831 RefSeq XP_009208575.1 339 PREDICTED: annexin A2 [Papio anubis]
GI:209862831 RefSeq XP_009427527.1 339 PREDICTED: annexin A2 [Pan troglodytes]
GI:209862831 RefSeq XP_009427528.1 339 PREDICTED: annexin A2 [Pan troglodytes]
GI:209862831 RefSeq XP_010372533.1 339 PREDICTED: annexin A2 [Rhinopithecus roxellana]
GI:209862831 RefSeq XP_010372534.1 339 PREDICTED: annexin A2 [Rhinopithecus roxellana]

Related Sequences to LMP000625 proteins

Reference Database Accession Length Protein Name
GI:50845388 EMBL CAE45704.1 357 hypothetical protein [Homo sapiens]
GI:50845388 GenBank AAH15834.1 339 Annexin A2 [Homo sapiens]
GI:209862831 GenBank AAP36435.1 340 Homo sapiens annexin A2, partial [synthetic construct]
GI:209862831 GenBank AAX43918.1 340 annexin A2, partial [synthetic construct]
GI:50845388 GenBank AAH66955.2 357 Annexin A2, partial [Homo sapiens]
GI:50845388 GenBank ACM82804.1 377 Sequence 8302 from patent US 6812339
GI:50845388 GenBank ACR85586.1 339 Sequence 145 from patent US 7521195
GI:209862831 GenBank ADA18317.1 357 Sequence 141 from patent US 7608413
GI:209862831 GenBank ADA18318.1 357 Sequence 142 from patent US 7608413
GI:209862831 GenBank ADT46466.1 357 Sequence 127 from patent US 7842466
GI:209862831 GenBank ADT46467.1 357 Sequence 128 from patent US 7842466
GI:50845388 GenBank AFX11676.1 339 Sequence 8 from patent US 8293522