Gene/Proteome Database (LMPD)

LMPD ID
LMP000626
Gene ID
12306
Species
Mus musculus (Mouse)
Gene Name
annexin A2
Gene Symbol
Anxa2
Synonyms
AW215814; Cal1h
Alternate Names
annexin A2; p36; PAP-IV; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; 33-kDa calcimedin; 36-kDa calelectrin; calpactin I heavy chain; calpactin-1 heavy chain; placental anticoagulant protein IV; 33kDa lymphocyte Ca<2+>- binding protein; 33-kDa lymphocyte Ca<2+>- binding protein
Chromosome
9
Map Location
9 C|9 38.58 cM

Proteins

annexin A2
Refseq ID NP_031611
Protein GI 6996913
UniProt ID P07356
mRNA ID NM_007585
Length 339
RefSeq Status PROVISIONAL
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Gene Information

Entrez Gene ID
12306
Gene Name
annexin A2
Gene Symbol
Anxa2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005604 IEA:UniProtKB-KW C basement membrane
GO:0005938 IEA:Ensembl C cell cortex
GO:0009986 IEA:Ensembl C cell surface
GO:0005737 IDA:MGI C cytoplasm
GO:0005769 IDA:MGI C early endosome
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0019897 IDA:MGI C extrinsic component of plasma membrane
GO:0031902 IEA:Ensembl C late endosome membrane
GO:0005811 IEA:Ensembl C lipid particle
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0044354 IEA:Ensembl C macropinosome
GO:0045121 IEA:Ensembl C membrane raft
GO:0030496 IEA:Ensembl C midbody
GO:0035749 IDA:BHF-UCL C myelin sheath adaxonal region
GO:0005634 IEA:Ensembl C nucleus
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0043234 IEA:Ensembl C protein complex
GO:0001726 IEA:Ensembl C ruffle
GO:0042383 IDA:MGI C sarcolemma
GO:0043220 IDA:BHF-UCL C Schmidt-Lanterman incisure
GO:0005544 IEA:UniProtKB-KW F calcium-dependent phospholipid binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005546 IEA:Ensembl F phosphatidylinositol-4,5-bisphosphate binding
GO:0019834 IEA:Ensembl F phospholipase A2 inhibitor activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0001525 IMP:MGI P angiogenesis
GO:0007589 IEA:Ensembl P body fluid secretion
GO:0030199 IMP:MGI P collagen fibril organization
GO:0042730 IMP:MGI P fibrinolysis
GO:0006900 IEA:Ensembl P membrane budding
GO:0001765 IEA:Ensembl P membrane raft assembly
GO:0036035 IEA:Ensembl P osteoclast development
GO:0051099 IMP:MGI P positive regulation of binding
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0031340 IEA:Ensembl P positive regulation of vesicle fusion
GO:0051290 IEA:Ensembl P protein heterotetramerization
GO:0072661 IEA:Ensembl P protein targeting to plasma membrane

REACTOME Pathway Links

REACTOME Pathway ID Description
5893225 Dissolution of Fibrin Clot
5893155 Hemostasis

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin repeat, conserved site
IPR002389 Annexin, type II

UniProt Annotations

Entry Information

Gene Name
annexin A2
Protein Entry
ANXA2_MOUSE
UniProt ID
P07356
Species
Mouse

Comments

Comment Type Description
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Interaction P08207:S100a10; NbExp=2; IntAct=EBI-738510, EBI-643986;
Miscellaneous It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Ptm ISGylated. {ECO:0000269|PubMed:16139798}.
Similarity Belongs to the annexin family. {ECO:0000305}.
Similarity Contains 4 annexin repeats. {ECO:0000305}.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane.
Subunit Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF. Interacts with ATP1B1 (By similarity). Interacts with COCH (By similarity). {ECO:0000250}.
Web Resource Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";

Identical and Related Proteins

Unique RefSeq proteins for LMP000626 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6996913 RefSeq NP_031611 339 annexin A2

Identical Sequences to LMP000626 proteins

Reference Database Accession Length Protein Name
GI:6996913 GenBank AGA52077.1 339 Sequence 12 from patent US 8329410
GI:6996913 PDB 4HRE 339 Chain A, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 PDB 4HRE 339 Chain C, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 PDB 4HRE 339 Chain B, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 PDB 4HRE 339 Chain D, Crystal Structure Of P11/annexin A2 Heterotetramer In Complex With Smarca3 Peptide
GI:6996913 RefSeq XP_006510859.1 339 PREDICTED: annexin A2 isoform X1 [Mus musculus]

Related Sequences to LMP000626 proteins

Reference Database Accession Length Protein Name
GI:6996913 DBBJ BAE29680.1 339 unnamed protein product [Mus musculus]
GI:6996913 RefSeq XP_005075540.1 339 PREDICTED: annexin A2 [Mesocricetus auratus]
GI:6996913 RefSeq XP_005347735.1 339 PREDICTED: annexin A2 [Microtus ochrogaster]
GI:6996913 RefSeq XP_006979351.1 339 PREDICTED: annexin A2 isoform X1 [Peromyscus maniculatus bairdii]
GI:6996913 RefSeq XP_006979352.1 339 PREDICTED: annexin A2 isoform X2 [Peromyscus maniculatus bairdii]
GI:6996913 RefSeq XP_007608088.1 339 PREDICTED: annexin A2 isoform X2 [Cricetulus griseus]