Gene/Proteome Database (LMPD)
LMPD ID
LMP000640
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class H
Gene Symbol
Synonyms
GPI-H
Alternate Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit H; PIG-H; phosphatidylinositol glycan, class H; phosphatidylinositol-glycan biosynthesis class H protein; phosphatidylinositol-glycan biosynthesis, class H protein
Chromosome
14
Map Location
14q24.1
EC Number
2.4.1.198
Summary
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| phosphatidylinositol N-acetylglucosaminyltransferase subunit H | |
|---|---|
| Refseq ID | NP_004560 |
| Protein GI | 4758920 |
| UniProt ID | Q14442 |
| mRNA ID | NM_004569 |
| Length | 188 |
| RefSeq Status | REVIEWED |
| MEDERSFSDICGGRLALQRRYYSPSCREFCLSCPRLSLRSLTAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDQETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDIVINEAIYMQKVIYYLCILLKDPVEPHGISQVVPVFQSAKPRLDCLIEVYRSCQEILAHQKATSTSP | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class H
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | TAS:ProtInc | C | endoplasmic reticulum |
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0000506 | IDA:MGI | C | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex |
| GO:0003824 | TAS:ProtInc | F | catalytic activity |
| GO:0017176 | IEA:UniProtKB-EC | F | phosphatidylinositol N-acetylglucosaminyltransferase activity |
| GO:0006501 | TAS:Reactome | P | C-terminal protein lipidation |
| GO:0006506 | TAS:ProtInc | P | GPI anchor biosynthetic process |
| GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
| GO:0006464 | TAS:ProtInc | P | cellular protein modification process |
| GO:0043687 | TAS:Reactome | P | post-translational protein modification |
| GO:0016254 | TAS:Reactome | P | preassembly of GPI anchor in ER membrane |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00563 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
| ko00563 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
| hsa01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_952 | Synthesis of glycosylphosphatidylinositol (GPI) |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR019328 | GPI-GlcNAc transferase complex, PIG-H component, conserved domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class H
Protein Entry
PIGH_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | UDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol. |
| Function | Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. |
| Pathway | Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. |
| Similarity | Belongs to the PIGH family. |
| Subcellular Location | Cytoplasm. |
| Subunit | Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity. |
| Web Resource | Name=Functional Glycomics Gateway - GTase; Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_557"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000640 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4758920 | RefSeq | NP_004560 | 188 | phosphatidylinositol N-acetylglucosaminyltransferase subunit H |
Identical Sequences to LMP000640 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758920 | GenBank | JAA03455.1 | 188 | phosphatidylinositol glycan anchor biosynthesis, class H [Pan troglodytes] |
| GI:4758920 | GenBank | JAA13190.1 | 188 | phosphatidylinositol glycan anchor biosynthesis, class H [Pan troglodytes] |
| GI:4758920 | GenBank | JAA34512.1 | 188 | phosphatidylinositol glycan anchor biosynthesis, class H [Pan troglodytes] |
| GI:4758920 | GenBank | AHD79970.1 | 188 | Sequence 30917 from patent US 8586006 |
| GI:4758920 | GenBank | AIC49393.1 | 188 | PIGH, partial [synthetic construct] |
| GI:4758920 | RefSeq | XP_003824123.1 | 188 | PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X3 [Pan paniscus] |
Related Sequences to LMP000640 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758920 | GenBank | AAP36142.1 | 189 | Homo sapiens phosphatidylinositol glycan, class H, partial [synthetic construct] |
| GI:4758920 | GenBank | AAX29099.1 | 189 | phosphatidylinositol glycan class H, partial [synthetic construct] |
| GI:4758920 | GenBank | AAX29100.1 | 189 | phosphatidylinositol glycan class H, partial [synthetic construct] |
| GI:4758920 | GenBank | ACM82031.1 | 208 | Sequence 7529 from patent US 6812339 |
| GI:4758920 | RefSeq | XP_003901999.1 | 188 | PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X1 [Papio anubis] |
| GI:4758920 | RefSeq | XP_004055373.1 | 188 | PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H [Gorilla gorilla gorilla] |