Gene/Proteome Database (LMPD)

LMPD ID
LMP000643
Gene ID
5337
Species
Homo sapiens (Human)
Gene Name
phospholipase D1, phosphatidylcholine-specific
Gene Symbol
PLD1
Synonyms
-
Alternate Names
phospholipase D1; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1
Chromosome
3
Map Location
3q26
EC Number
3.1.4.4
Summary
This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
Orthologs
View orthologs and multiple alignments for PLD1

Proteins

phospholipase D1 isoform a
Refseq ID NP_002653
Protein GI 4505873
UniProt ID Q13393
mRNA ID NM_002662
Length 1074
RefSeq Status REVIEWED
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
phospholipase D1 isoform b
Refseq ID NP_001123553
Protein GI 194272176
UniProt ID Q59EA4
mRNA ID NM_001130081
Length 1036
RefSeq Status REVIEWED
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSNTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT

Gene Information

Entrez Gene ID
5337
Gene Name
phospholipase D1, phosphatidylcholine-specific
Gene Symbol
PLD1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:MGI C Golgi apparatus
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0005768 IDA:MGI C endosome
GO:0005765 IDA:UniProtKB C lysosomal membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0004630 TAS:ProtInc F phospholipase D activity
GO:0007265 TAS:ProtInc P Ras protein signal transduction
GO:0006935 TAS:ProtInc P chemotaxis
GO:0050830 IEA:Ensembl P defense response to Gram-positive bacterium
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0006655 TAS:Reactome P phosphatidylglycerol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0007264 TAS:ProtInc P small GTPase mediated signal transduction
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04724 Glutamatergic synapse
hsa04014 Ras signaling pathway
hsa04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR015679 Phospholipase D family
IPR016555 Phospholipase D, eukaryota
IPR025202 Phospholipase D-like domain
IPR001736 Phospholipase D/Transphosphatidylase
IPR001683 Phox homologous domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase D1, phosphatidylcholine-specific
Protein Entry
Q59EA4_HUMAN
UniProt ID
Q59EA4
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=PLD1A; IsoId=Q13393-1; Sequence=Displayed; Name=PLD1B; IsoId=Q13393-2; Sequence=VSP_005020; Name=PLD1C; IsoId=Q13393-3; Sequence=VSP_005018, VSP_005019; Name=PLD1D; IsoId=Q13393-4; Sequence=VSP_005021, VSP_005022;
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme Regulation Stimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.
Function Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Interaction P23528:CFL1; NbExp=4; IntAct=EBI-2827556, EBI-352733;
Similarity Belongs to the phospholipase D family.
Similarity Contains 1 PH domain.
Similarity Contains 1 PX (phox homology) domain.
Similarity Contains 2 PLD phosphodiesterase domains.
Subcellular Location Cytoplasm, perinuclear region . Endoplasmic reticulum membrane ; Lipid-anchor {ECO
Subunit Interacts with PIP5K1B.
Tissue Specificity Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLD1ID43716ch3q26.html";
Web Resource Name=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D";

Identical and Related Proteins

Unique RefSeq proteins for LMP000643 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505873 RefSeq NP_002653 1074 phospholipase D1 isoform a
194272176 RefSeq NP_001123553 1036 phospholipase D1 isoform b

Identical Sequences to LMP000643 proteins

Reference Database Accession Length Protein Name
GI:194272176 DBBJ BAG10992.1 1036 phospholipase D1, partial [synthetic construct]
GI:194272176 GenBank AAM57887.1 1036 Sequence 4 from patent US 6379665
GI:4505873 GenBank EAW78480.1 1074 phospholipase D1, phosphatidylcholine-specific [Homo sapiens]
GI:4505873 GenBank ADR82735.1 1074 phospholipase D1, phosphatidylcholine-specific, partial [synthetic construct]
GI:4505873 GenBank ADS18223.1 1074 Sequence 80 from patent US 7763418
GI:4505873 GenBank AHD71048.1 1074 Sequence 4516 from patent US 8586006
GI:4505873 GenBank AIC49409.1 1074 PLD1, partial [synthetic construct]
GI:4505873 RefSeq XP_005247590.1 1074 PREDICTED: phospholipase D1 isoform X1 [Homo sapiens]
GI:194272176 RefSeq XP_005247591.1 1036 PREDICTED: phospholipase D1 isoform X2 [Homo sapiens]

Related Sequences to LMP000643 proteins

Reference Database Accession Length Protein Name
GI:194272176 DBBJ BAD93144.1 1059 phospholipase D1 variant, partial [Homo sapiens]
GI:4505873 GenBank ACM85661.1 1086 Sequence 11159 from patent US 6812339
GI:4505873 GenBank JAA07444.1 1074 phospholipase D1, phosphatidylcholine-specific [Pan troglodytes]
GI:194272176 GenBank JAA16737.1 1036 phospholipase D1, phosphatidylcholine-specific [Pan troglodytes]
GI:194272176 GenBank JAA27649.1 1036 phospholipase D1, phosphatidylcholine-specific [Pan troglodytes]
GI:4505873 GenBank JAA27650.1 1074 phospholipase D1, phosphatidylcholine-specific [Pan troglodytes]
GI:194272176 GenBank JAA37906.1 1036 phospholipase D1, phosphatidylcholine-specific [Pan troglodytes]
GI:4505873 GenBank JAA37907.1 1074 phospholipase D1, phosphatidylcholine-specific [Pan troglodytes]
GI:194272176 RefSeq XP_003831986.1 1036 PREDICTED: phospholipase D1 isoform X1 [Pan paniscus]
GI:4505873 RefSeq XP_008955556.1 1074 PREDICTED: phospholipase D1 isoform X2 [Pan paniscus]
GI:4505873 RefSeq XP_009445127.1 1074 PREDICTED: phospholipase D1 isoform X1 [Pan troglodytes]
GI:194272176 RefSeq XP_009445128.1 1036 PREDICTED: phospholipase D1 isoform X2 [Pan troglodytes]