Gene/Proteome Database (LMPD)

LMPD ID
LMP000645
Gene ID
13101
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 2, subfamily d, polypeptide 10
Gene Symbol
Cyp2d10
Synonyms
AI303445; Cyp2d; P450-2D
Alternate Names
cytochrome P450 2D10; CYPIID10; cytochrome P450CB; cytochrome P450, 2d10; cytochrome P450-16-alpha; testosterone 16-alpha hydroxylase
Chromosome
15
Map Location
15 E1|15 38.58 cM
EC Number
1.14.14.1

Proteins

cytochrome P450 2D10
Refseq ID NP_034135
Protein GI 31981816
UniProt ID P24456
mRNA ID NM_010005
Length 504
RefSeq Status VALIDATED
MELLTGAGLWSVAIFTVIFILLVDLMHRHQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSLYKLQNRYGDVFSLQMGWKPMVVINGLKAMKEVLLTCGEDTADRPQVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEARHLCDAFTAQAGQPINPNTMLNNAVCNVIASLIFARRFEYEDPYLIRMQKVLEDSLTEISGLIPEVLNMFPILLRIPGLPGKVFQGQKSLLAIVENLLTENRNTWDPDQPPRNLTDAFLAEIEKVKGNAESSFNDENLRMVVLDLFTAGMVTTSTTLSWALLLMILHPDVQRRVQQEIDAVIGQVRHPEMADQARMPYTNAVIHEVQRFGDIAPLNLPRITSRDIEVQDFLIPKGSILIPNMSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQHFSFSVPNGQPRPRNLGVFPFPVAPYPYQLCAVMREQGH

Gene Information

Entrez Gene ID
13101
Gene Name
cytochrome P450, family 2, subfamily d, polypeptide 10
Gene Symbol
Cyp2d10
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding

KEGG Pathway Links

KEGG Pathway ID Description
mmu04726 Serotonergic synapse
ko00140 Steroid hormone biosynthesis
mmu00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5892994 Xenobiotics

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily d, polypeptide 10
Protein Entry
CP2DA_MOUSE
UniProt ID
P24456
Species
Mouse

Comments

Comment Type Description
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Induction P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP000645 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31981816 RefSeq NP_034135 504 cytochrome P450 2D10

Identical Sequences to LMP000645 proteins

Reference Database Accession Length Protein Name
GI:31981816 GenBank AAH10989.1 504 Cytochrome P450, family 2, subfamily d, polypeptide 10 [Mus musculus]
GI:31981816 GenBank AAH57924.1 504 Cytochrome P450, family 2, subfamily d, polypeptide 10 [Mus musculus]
GI:31981816 GenBank EDL04503.1 504 mCG133073, isoform CRA_b [Mus musculus]
GI:31981816 SwissProt P24456.2 504 RecName: Full=Cytochrome P450 2D10; AltName: Full=CYPIID10; AltName: Full=Cytochrome P450-16-alpha; AltName: Full=Cytochrome P450CB; AltName: Full=Testosterone 16-alpha hydroxylase [Mus musculus]

Related Sequences to LMP000645 proteins

Reference Database Accession Length Protein Name
GI:31981816 GenBank AAA79023.1 504 testosterone 16-alpha-hydroxylase [Mus musculus domesticus]
GI:31981816 GenBank AAA39878.1 504 cytochrome P450cb [Mus musculus domesticus]
GI:31981816 GenBank AAC52246.1 504 P45016a-ms2 [Mus spretus]
GI:31981816 GenBank AAQ79704.1 504 Sequence 23 from patent US 6376753
GI:31981816 RefSeq NP_001098001.1 504 cytochrome P450 2D11 [Mus musculus]
GI:31981816 SwissProt P24457.2 504 RecName: Full=Cytochrome P450 2D11; AltName: Full=CYPIID11; AltName: Full=Cytochrome P450-16-alpha; AltName: Full=Cytochrome P450CC; AltName: Full=Testosterone 16-alpha hydroxylase [Mus musculus]