Gene/Proteome Database (LMPD)
LMPD ID
LMP000649
Gene ID
Species
Homo sapiens (Human)
Gene Name
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Gene Symbol
Synonyms
CDS
Alternate Names
phosphatidate cytidylyltransferase 1; CDS 1; CDP-DG synthase 1; CDP-DAG synthase 1; CDP-DG synthetase 1; CDP-diglyceride synthase 1; CDP-diglyceride synthetase 1; CDP-diacylglycerol synthase 1; CDP-diglyceride pyrophosphorylase 1; CTP:phosphatidate cytidylyltransferase 1
Chromosome
4
Map Location
4q21.23
EC Number
2.7.7.41
Summary
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| phosphatidate cytidylyltransferase 1 | |
|---|---|
| Refseq ID | NP_001254 |
| Protein GI | 22035624 |
| UniProt ID | Q92903 |
| mRNA ID | NM_001263 |
| Length | 461 |
| RefSeq Status | REVIEWED |
| MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDIDDRYGDLDSRTDSDIPEIPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQVKCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVVFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQTYSLPPFLKAVLRQERVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYKTLKTHLIEKGILQPTLKV | |
Gene Information
Entrez Gene ID
Gene Name
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | ISS:UniProtKB | C | endoplasmic reticulum |
| GO:0005789 | ISS:UniProtKB | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0004142 | NAS:UniProtKB | F | diacylglycerol cholinephosphotransferase activity |
| GO:0004605 | IDA:UniProtKB | F | phosphatidate cytidylyltransferase activity |
| GO:0006657 | NAS:GOC | P | CDP-choline pathway |
| GO:0016024 | IDA:UniProtKB | P | CDP-diacylglycerol biosynthetic process |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0006661 | IDA:UniProtKB | P | phosphatidylinositol biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0007602 | NAS:UniProtKB | P | phototransduction |
| GO:0007165 | NAS:UniProtKB | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00564 | Glycerophospholipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-5667 | CDP-diacylglycerol biosynthesis I |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121401 | Glycerophospholipid biosynthesis |
| REACT_121000 | Synthesis of PI |
Domain Information
UniProt Annotations
Entry Information
Gene Name
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Protein Entry
CDS1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | CTP + phosphatidate = diphosphate + CDP- diacylglycerol. |
| Cofactor | Name=Mg(2+); Xref=ChEBI |
| Function | Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. |
| Similarity | Belongs to the CDS family. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO |
| Subunit | Interacts with FOS; this interaction may enhance catalytic activity. |
| Tissue Specificity | Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000649 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22035624 | RefSeq | NP_001254 | 461 | phosphatidate cytidylyltransferase 1 |
Identical Sequences to LMP000649 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22035624 | DBBJ | BAG36912.1 | 461 | unnamed protein product [Homo sapiens] |
| GI:22035624 | GenBank | AAH74833.1 | 461 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [Homo sapiens] |
| GI:22035624 | GenBank | AAH74881.1 | 461 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [Homo sapiens] |
| GI:22035624 | GenBank | EAX05950.1 | 461 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1, isoform CRA_a [Homo sapiens] |
| GI:22035624 | GenBank | EAX05951.1 | 461 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1, isoform CRA_a [Homo sapiens] |
| GI:22035624 | GenBank | AIC48483.1 | 461 | CDS1, partial [synthetic construct] |
Related Sequences to LMP000649 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22035624 | GenBank | AAO96507.1 | 461 | Sequence 2 from patent US 6503700 |
| GI:22035624 | GenBank | ACM85741.1 | 516 | Sequence 11239 from patent US 6812339 |
| GI:22035624 | GenBank | JAA08534.1 | 461 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [Pan troglodytes] |
| GI:22035624 | RefSeq | XP_517179.2 | 461 | PREDICTED: phosphatidate cytidylyltransferase 1 [Pan troglodytes] |
| GI:22035624 | RefSeq | XP_003832288.1 | 461 | PREDICTED: phosphatidate cytidylyltransferase 1 isoform X1 [Pan paniscus] |
| GI:22035624 | RefSeq | XP_004038967.1 | 461 | PREDICTED: phosphatidate cytidylyltransferase 1 [Gorilla gorilla gorilla] |