Gene/Proteome Database (LMPD)
LMPD ID
LMP000660
Gene ID
Species
Mus musculus (Mouse)
Gene Name
apolipoprotein B receptor
Gene Symbol
Synonyms
Apob-48r; Apob48r
Alternate Names
apolipoprotein B receptor; apolipoprotein B48 receptor; apolipoprotein B-48 receptor; apolipoprotein B-100 receptor
Chromosome
7
Map Location
7 F3|7
Proteins
| apolipoprotein B receptor | |
|---|---|
| Refseq ID | NP_612183 |
| Protein GI | 19923863 |
| UniProt ID | Q8VBT6 |
| mRNA ID | NM_138310 |
| Length | 942 |
| RefSeq Status | PROVISIONAL |
| MDFLRLRLPGLHQALRGALDSFSAFVSYLVGDTVPTVERQTQAAEELGEVTEGKVVGEEAQEVLEGLRSGQSEGVEAPEETRRCQEGSLAGEQTWGWRADSSARPQAERQDTGSWKAAEDARGQEPSVPLKPEAEPGTHRDRSSNTAQEIWEHGEEEASSGEPLRTCEQKEEEEEVVRAAESGMAEGVESQPTWHSEPGGNAGTEGQHVTEDSKEIDWVAKDMVAEIEWFGAKGIDKEEERMVPMRDGERARAQGTQCPGAESEDQAMLSREAWTVSDREGADSLGVQGTEYGSDPGDNFPGTTGRVWVLEEADKGDQQDEVDEKREAEVRFPIQTLEAERTGEMTEGHIAEEEAMGEQETEGSFEDEERQDLAIRDNGVSLEEEVRAEESSREKRNSWATEPTLVLDTEAKDEPDWEDSPEVSTEELFVGERSEAAQMTPEVLRVKVTEGQDPELVRHSQALTKQLEEGQKGQEETSGAPDLSPERVLSLKEYPGPVGFAGPELEAWGNWSRGVDRRNSQEVKADAEAGKEQTATEQAVEIRAEGGQEAQQPEVFGSGGEEALTSVALNPELEGSQGAEAGTEESVEESKPTENEAAEEEAVVPWEADGTCRKRRLEEVTLSLQDSEDTETSYLAEEIIVGIRAVDTEEGPKWEAGLAPETELGKAWCSEGRGEAGRGTELEETTEKQSGQEVGLVGSAEKVSGYDIQEIDGTEEGEQAEMETSVMAEDIRGTDGVTLGSQAERAEGSITPMETEGLLRDQMLLEEEAGGGQSREQKVHNSEGEIQTLDDSSDQEGQQTHQIPTVAVPGPLESAEATAGAPGDVHSNWNEALLPGSRLDVSVPRSRVLLSRSSSRRRSRPSFHRISVPEPQCDPPSPQPQAERPVPEQSSLQLEETPELSATKPEGTPVPARRKMLGRGFGFAHPGMMQELQARLSQPKPQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042627 | IEA:UniProtKB-KW | C | chylomicron |
| GO:0034362 | IEA:UniProtKB-KW | C | low-density lipoprotein particle |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0030229 | IDA:MGI | F | very-low-density lipoprotein particle receptor activity |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0006898 | IDA:GOC | P | receptor-mediated endocytosis |
| GO:0006641 | IDA:MGI | P | triglyceride metabolic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026158 | Apolipoprotein B receptor |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Finds at the highest levels in E7, then progressively lower at E11 and E15, and finally very diminished at the E17. {ECO:0000269|PubMed:12177162}. |
| Function | Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:12177162}. |
| Induction | Increased in high-fat diet ATM (adipose tissue macrophages). {ECO:0000269|PubMed:17192460}. |
| Ptm | There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein (By similarity). {ECO:0000250}. |
| Subunit | Homodimer. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in spleen, lung and skeletal muscle, and weakly in brain, heart, kidney, and testis. {ECO:0000269|PubMed:12177162}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000660 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 19923863 | RefSeq | NP_612183 | 942 | apolipoprotein B receptor |
Identical Sequences to LMP000660 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:19923863 | GenBank | AAL54862.1 | 942 | apolipoprotein B48 receptor [Mus musculus] |
| GI:19923863 | GenBank | AAL54863.1 | 942 | apolipoprotein B48 receptor [Mus musculus] |
| GI:19923863 | GenBank | AAH30718.1 | 942 | Apolipoprotein B48 receptor [Mus musculus] |
| GI:19923863 | SwissProt | Q8VBT6.1 | 942 | RecName: Full=Apolipoprotein B receptor; AltName: Full=Apolipoprotein B-100 receptor; Short=Apolipoprotein B48 receptor; Short=apoB-48R [Mus musculus] |
Related Sequences to LMP000660 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:19923863 | GenBank | EDL17401.1 | 942 | apolipoprotein B48 receptor, isoform CRA_c [Mus musculus] |
| GI:19923863 | GenBank | EDM17435.1 | 970 | similar to apolipoprotein B48 receptor (predicted), isoform CRA_b [Rattus norvegicus] |
| GI:19923863 | GenBank | ERE78621.1 | 961 | apolipoprotein B receptor [Cricetulus griseus] |
| GI:19923863 | RefSeq | XP_006230381.1 | 1016 | PREDICTED: apolipoprotein B receptor isoform X1 [Rattus norvegicus] |
| GI:19923863 | RefSeq | XP_006507462.1 | 751 | PREDICTED: apolipoprotein B receptor isoform X1 [Mus musculus] |
| GI:19923863 | RefSeq | XP_007614415.1 | 961 | PREDICTED: apolipoprotein B receptor [Cricetulus griseus] |