Gene/Proteome Database (LMPD)

LMPD ID
LMP000665
Gene ID
16440
Species
Mus musculus (Mouse)
Gene Name
inositol 1,4,5-triphosphate receptor 3
Gene Symbol
Itpr3
Synonyms
Ip3r3; Itpr-3
Alternate Names
inositol 1,4,5-trisphosphate receptor type 3; IP3R 3; insP3R3; IP3 receptor; type 3 InsP3 receptor; type 3 inositol 1,4,5-trisphosphate receptor
Chromosome
17
Map Location
17 A3.3|17 19.0 cM

Proteins

inositol 1,4,5-trisphosphate receptor type 3
Refseq ID NP_542120
Protein GI 61102728
UniProt ID P70227
mRNA ID NM_080553
Length 2670
RefSeq Status VALIDATED
MNEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYRGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDVSDPKAAGLGAQGRTGRRNAGEKIKYRLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQIFGILKAPFRDKGGEGPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFASTMEFVEDYLNNVVSEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCIQAPAAMLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPAGVGVPEQLDRSKFEDNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSSTATMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPSLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSVKGEEVEAGATKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKSDNKMLEILRYTHQFLQKFCAGNPGNQALLHKHLQLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVTVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCSAAAQRSAANYKTATRTFPRVIPTANQWDYKNIIEKLQDIIMALEERLKPLVQAELSVLVDMLHWPELLFPEGSEAYQRCESGGFLSKLIRHTKGLMESEEKLCVKVLRTLQQMLLKKSKFGDRGNQLRKMLLQNYLQNRKSGARGELTDPTGSGLDQDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQETKSTVAVNMSDLGSQPREDREPADPATKGRVSSFSMPSSSRYLLGLGLHRGHDMSERAQNNEMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVRRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKRYSVRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPGNHSRASPLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEEPDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVSHLTSQLNELKEQMTEQRKRRQRLGFVDVQNCMSR

Gene Information

Entrez Gene ID
16440
Gene Name
inositol 1,4,5-triphosphate receptor 3
Gene Symbol
Itpr3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005789 IDA:UniProtKB C endoplasmic reticulum membrane
GO:0005887 IEA:Ensembl C integral component of plasma membrane
GO:0005730 IDA:MGI C nucleolus
GO:0005654 IDA:MGI C nucleoplasm
GO:0005634 IDA:MGI C nucleus
GO:0043235 ISO:MGI C receptor complex
GO:0070679 IEA:Ensembl F inositol 1,4,5 trisphosphate binding
GO:0005220 IDA:UniProtKB F inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005218 IDA:UniProtKB F intracellular ligand-gated calcium channel activity
GO:0035091 IDA:MGI F phosphatidylinositol binding
GO:0006816 IDA:MGI P calcium ion transport
GO:0060402 IDA:UniProtKB P calcium ion transport into cytosol
GO:0048016 IDA:GOC P inositol phosphate-mediated signaling
GO:0060291 IMP:MGI P long-term synaptic potentiation
GO:0007613 IMP:MGI P memory
GO:0051592 IEA:Ensembl P response to calcium ion
GO:0050913 IMP:MGI P sensory perception of bitter taste
GO:0050916 IMP:MGI P sensory perception of sweet taste
GO:0050917 IMP:MGI P sensory perception of umami taste

KEGG Pathway Links

KEGG Pathway ID Description
mmu04022 cGMP-PKG signaling pathway
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04921 Oxytocin signaling pathway
mmu04611 Platelet activation

Domain Information

InterPro Annotations

Accession Description
IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR005821 Ion transport domain
IPR016093 MIR_motif
IPR000699 RIH (RyR and IP3R Homology) domain
IPR015925 Ryanodine receptor-related
IPR013662 RyR/IP3R Homology associated domain

UniProt Annotations

Entry Information

Gene Name
inositol 1,4,5-triphosphate receptor 3
Protein Entry
ITPR3_MOUSE
UniProt ID
P70227
Species
Mouse

Comments

Comment Type Description
Domain The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Function Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. {ECO:0000269|PubMed:20813840, ECO:0000269|PubMed:21030605}.
Ptm Phosphorylated on tyrosine residues (By similarity). Phosphorylated by AKT1 on serine and/or threonine residues. {ECO:0000250, ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:21030605}.
Similarity Belongs to the InsP3 receptor family. {ECO:0000305}.
Similarity Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15632133, ECO:0000269|PubMed:21030605}; Multi- pass membrane protein {ECO:0000269|PubMed:15632133, ECO:0000269|PubMed:21030605}.
Subunit Homotetramer. Interacts with TRPC1, TRPC3, TRPC4 and CABP1 (By similarity). Interacts with SIGMAR1, AKT1 and PML. Interacts with TMBIM4/LFG4. Interacts with CEMIP (By similarity). Interacts with LRMP (via coiled-coil domain). Interacts with TESPA1. {ECO:0000250, ECO:0000269|PubMed:11149946, ECO:0000269|PubMed:20071408, ECO:0000269|PubMed:21030605, ECO:0000269|PubMed:23650607}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000665 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
61102728 RefSeq NP_542120 2670 inositol 1,4,5-trisphosphate receptor type 3

Identical Sequences to LMP000665 proteins

Reference Database Accession Length Protein Name
GI:61102728 DBBJ BAD90683.1 2670 type-3 inositol 1,4,5-trisphosphate receptor [Mus musculus]
GI:61102728 SwissProt P70227.3 2670 RecName: Full=Inositol 1,4,5-trisphosphate receptor type 3; AltName: Full=IP3 receptor isoform 3; Short=IP3R 3; Short=InsP3R3; AltName: Full=Type 3 inositol 1,4,5-trisphosphate receptor; Short=Type 3 InsP3 receptor [Mus musculus]

Related Sequences to LMP000665 proteins

Reference Database Accession Length Protein Name
GI:61102728 GenBank AAA41446.1 2670 inositol triphosphate receptor subtype 3 [Rattus norvegicus]
GI:61102728 GenBank ACT21452.1 2670 inositol 1,4,5-trisphosphate receptor type 3 [Rattus norvegicus]
GI:61102728 RefSeq NP_037270.1 2670 inositol 1,4,5-trisphosphate receptor type 3 [Rattus norvegicus]
GI:61102728 RefSeq XP_006523775.1 2797 PREDICTED: inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [Mus musculus]
GI:61102728 RefSeq XP_008770932.1 2670 PREDICTED: inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [Rattus norvegicus]
GI:61102728 SwissProt Q63269.1 2670 RecName: Full=Inositol 1,4,5-trisphosphate receptor type 3; AltName: Full=IP3 receptor isoform 3; Short=IP3R 3; Short=InsP3R3; AltName: Full=Type 3 inositol 1,4,5-trisphosphate receptor; Short=Type 3 InsP3 receptor [Rattus norvegicus]