Gene/Proteome Database (LMPD)

LMPD ID
LMP000666
Gene ID
1551
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 3, subfamily A, polypeptide 7
Gene Symbol
CYP3A7
Synonyms
CP37; CYPIIIA7; P-450(HFL33); P-450111A7; P450-HFLA
Alternate Names
cytochrome P450 3A7; cytochrome P450-HFLA; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIIA, polypeptide 7
Chromosome
7
Map Location
7q21-q22.1
EC Number
1.14.14.1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3AP1 pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Apr 2014]
Orthologs
View orthologs and multiple alignments for CYP3A7

Proteins

cytochrome P450 3A7
Refseq ID NP_000756
Protein GI 608788370
UniProt ID P24462
mRNA ID NM_000765
Length 503
RefSeq Status REVIEWED
MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

Gene Information

Entrez Gene ID
1551
Gene Name
cytochrome P450, family 3, subfamily A, polypeptide 7
Gene Symbol
CYP3A7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 ISS:UniProtKB F monooxygenase activity
GO:0019825 TAS:ProtInc F oxygen binding
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05204 Chemical carcinogenesis
hsa00830 Retinol metabolism
hsa00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR008072 Cytochrome P450, E-class, CYP3A
IPR002402 Cytochrome P450, E-class, group II
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 3, subfamily A, polypeptide 7
Protein Entry
CP3A7_HUMAN
UniProt ID
P24462
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P24462-1; Sequence=Displayed; Name=2; IsoId=P24462-2; Sequence=VSP_055577;
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Induction P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web Resource Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP3A7 alleles; URL="http://www.cypalleles.ki.se/cyp3a7.htm";

Identical and Related Proteins

Unique RefSeq proteins for LMP000666 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
608788370 RefSeq NP_000756 503 cytochrome P450 3A7

Identical Sequences to LMP000666 proteins

Reference Database Accession Length Protein Name
GI:608788370 GenBank AAG32289.1 503 cytochrome P450 polypeptide 7 [Homo sapiens]
GI:608788370 GenBank AAH67436.1 503 Cytochrome P450, family 3, subfamily A, polypeptide 7 [Homo sapiens]
GI:608788370 GenBank EAL23867.1 503 cytochrome P450, family 3, subfamily A, polypeptide 7 [Homo sapiens]
GI:608788370 GenBank EAW76637.1 503 cytochrome P450, family 3, subfamily A, polypeptide 7 [Homo sapiens]
GI:608788370 GenBank AHE01174.1 503 Sequence 56090 from patent US 8586006
GI:608788370 GenBank AIC54254.1 503 CYP3A7, partial [synthetic construct]

Related Sequences to LMP000666 proteins

Reference Database Accession Length Protein Name
GI:608788370 GenBank AAG48618.1 535 cytochrome P450 variant 3A7 [Homo sapiens]
GI:608788370 GenBank ACM83063.1 508 Sequence 8561 from patent US 6812339
GI:608788370 RefSeq XP_003318674.1 503 PREDICTED: cytochrome P450 3A7 isoform X1 [Pan troglodytes]
GI:608788370 RefSeq NP_001243426.2 535 CYP3A7-CYP3AP1 readthrough [Homo sapiens]
GI:608788370 RefSeq XP_009240868.1 502 PREDICTED: LOW QUALITY PROTEIN: cytochrome P450 3A7-like [Pongo abelii]
GI:608788370 SwissProt P24462.2 503 RecName: Full=Cytochrome P450 3A7; AltName: Full=CYPIIIA7; AltName: Full=Cytochrome P450-HFLA [Homo sapiens]