Gene/Proteome Database (LMPD)

LMPD ID
LMP000667
Gene ID
1581
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 7, subfamily A, polypeptide 1
Gene Symbol
CYP7A1
Synonyms
CP7A; CYP7; CYPVII
Alternate Names
cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cholesterol 7-alpha-hydroxylase; cytochrome P450, subfamily VIIA polypeptide 1
Chromosome
8
Map Location
8q11-q12
EC Number
1.14.13.17
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
Orthologs
View orthologs and multiple alignments for CYP7A1

Proteins

cholesterol 7-alpha-monooxygenase
Refseq ID NP_000771
Protein GI 166295200
UniProt ID P22680
mRNA ID NM_000780
Length 504
RefSeq Status REVIEWED
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL

Gene Information

Entrez Gene ID
1581
Gene Name
cytochrome P450, family 7, subfamily A, polypeptide 1
Gene Symbol
CYP7A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0008123 ISS:UniProtKB F cholesterol 7-alpha-monooxygenase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0006699 IDA:UniProtKB P bile acid biosynthetic process
GO:0008206 TAS:Reactome P bile acid metabolic process
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0071397 ISS:UniProtKB P cellular response to cholesterol
GO:0071333 IDA:UniProtKB P cellular response to glucose stimulus
GO:0006707 ISS:UniProtKB P cholesterol catabolic process
GO:0042632 ISS:UniProtKB P cholesterol homeostasis
GO:0070857 IDA:UniProtKB P regulation of bile acid biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0016125 TAS:Reactome P sterol metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04976 Bile secretion
hsa03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
IPR017972 Cytochrome P450, conserved site
IPR002403 Cytochrome P450, E-class, group IV

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 7, subfamily A, polypeptide 1
Protein Entry
CP7A1_HUMAN
UniProt ID
P22680
Species
Human

Comments

Comment Type Description
Catalytic Activity Cholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.
Induction Up-regulated by glucose and by cholestyramine. Down- regulated by chenodeoxycholic acid. {ECO
Pathway Lipid metabolism; bile acid biosynthesis.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Detected in liver.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CYP7A1ID40254ch8q12.html";
Web Resource Name=Wikipedia; Note=Cholesterol-7 alpha-hydroxylase entry; URL="http://en.wikipedia.org/wiki/Cholesterol_7_alpha-hydroxylase";

Identical and Related Proteins

Unique RefSeq proteins for LMP000667 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
166295200 RefSeq NP_000771 504 cholesterol 7-alpha-monooxygenase

Identical Sequences to LMP000667 proteins

Reference Database Accession Length Protein Name
GI:166295200 GenBank AAE21471.1 504 Sequence 8 from patent US 5851780
GI:166295200 GenBank AAR81287.1 504 Sequence 4 from patent US 6660317
GI:166295200 GenBank AAI01778.1 504 Cytochrome P450, family 7, subfamily A, polypeptide 1 [Homo sapiens]
GI:166295200 GenBank AAI12185.1 504 Cytochrome P450, family 7, subfamily A, polypeptide 1 [Homo sapiens]
GI:166295200 GenBank EAW86811.1 504 cytochrome P450, family 7, subfamily A, polypeptide 1 [Homo sapiens]
GI:166295200 pat US 504 Sequence 28 from patent US 5753431

Related Sequences to LMP000667 proteins

Reference Database Accession Length Protein Name
GI:166295200 EMBL CAA39568.1 504 cholesterol 7-alpha-hydroxylase [Homo sapiens]
GI:166295200 GenBank ACM85304.1 507 Sequence 10802 from patent US 6812339
GI:166295200 GenBank AHD78004.1 504 Sequence 24983 from patent US 8586006
GI:166295200 RefSeq XP_519773.2 504 PREDICTED: cholesterol 7-alpha-monooxygenase [Pan troglodytes]
GI:166295200 RefSeq XP_003822023.1 504 PREDICTED: cholesterol 7-alpha-monooxygenase [Pan paniscus]
GI:166295200 RefSeq XP_004047109.1 504 PREDICTED: cholesterol 7-alpha-monooxygenase-like [Gorilla gorilla gorilla]