Gene/Proteome Database (LMPD)

LMPD ID
LMP000668
Gene ID
13082
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 26, subfamily a, polypeptide 1
Gene Symbol
Cyp26a1
Synonyms
Cyp26; P450RA; P450RAI; RAH
Alternate Names
cytochrome P450 26A1; cytochrome P450RAI; retinoic acid hydrolase; retinoic acid 4-hydroxylase; cytochrome P450, 26, retinoic acid A1; retinoic acid-metabolizing cytochrome
Chromosome
19
Map Location
19|19 C2-C3
EC Number
1.14.-.-

Proteins

cytochrome P450 26A1
Refseq ID NP_031837
Protein GI 178057351
UniProt ID O55127
mRNA ID NM_007811
Length 497
RefSeq Status VALIDATED
MGLPALLASALCTFVLPLLLFLAALKLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQAFSREALQCYVPVIAEEVSSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQATEPDGGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSNQDNKLDMETLEQLKYTGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFQGDI

Gene Information

Entrez Gene ID
13082
Gene Name
cytochrome P450, family 26, subfamily a, polypeptide 1
Gene Symbol
Cyp26a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008401 IEA:Ensembl F retinoic acid 4-hydroxylase activity
GO:0001972 IEA:Ensembl F retinoic acid binding
GO:0009952 IMP:MGI P anterior/posterior pattern specification
GO:0071300 IEP:UniProtKB P cellular response to retinoic acid
GO:0007417 IMP:MGI P central nervous system development
GO:0014032 IGI:MGI P neural crest cell development
GO:0034653 ISA:MGI P retinoic acid catabolic process
GO:0042573 IMP:MGI P retinoic acid metabolic process
GO:0048384 IGI:MGI P retinoic acid receptor signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 26, subfamily a, polypeptide 1
Protein Entry
CP26A_MOUSE
UniProt ID
O55127
Species
Mouse

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Induction By retinoic acid.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP000668 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
178057351 RefSeq NP_031837 497 cytochrome P450 26A1

Identical Sequences to LMP000668 proteins

Reference Database Accession Length Protein Name
GI:178057351 GenBank AAH12673.1 497 Cytochrome P450, family 26, subfamily a, polypeptide 1 [Mus musculus]
GI:178057351 GenBank EDL41793.1 497 cytochrome P450, family 26, subfamily a, polypeptide 1 [Mus musculus]

Related Sequences to LMP000668 proteins

Reference Database Accession Length Protein Name
GI:178057351 EMBL CAA73206.1 497 P450RA protein [Mus musculus]
GI:178057351 EMBL CAD57248.1 497 unnamed protein product [Mus musculus]
GI:178057351 GenBank AAY03401.1 497 Sequence 32 from patent US 6861238
GI:178057351 GenBank ACC10883.1 497 Sequence 32 from patent US 7335484
GI:178057351 GenBank ACM97066.1 497 Sequence 32 from patent US 7473422
GI:178057351 SwissProt O55127.1 497 RecName: Full=Cytochrome P450 26A1; AltName: Full=Cytochrome P450RAI; AltName: Full=Retinoic acid 4-hydroxylase; AltName: Full=Retinoic acid-metabolizing cytochrome [Mus musculus]