Gene/Proteome Database (LMPD)

LMPD ID
LMP000687
Gene ID
5293
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene Symbol
PIK3CD
Synonyms
APDS; IMD14; P110DELTA; PI3K; p110D
Chromosome
1
Map Location
1p36.2
Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Orthologs
View orthologs and multiple alignments for PIK3CD

Proteins

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Refseq ID NP_005017
Protein GI 156564405
UniProt ID O00329
mRNA ID NM_005026
Length 1044
RefSeq Status REVIEWED
MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ

Gene Information

Entrez Gene ID
5293
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene Symbol
PIK3CD
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016301 IEA:UniProtKB-KW F kinase activity
GO:0016773 IEA:InterPro F phosphotransferase activity, alcohol group as acceptor
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04024 cAMP signaling pathway
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Protein Entry
PK3CD_HUMAN
UniProt ID
O00329
Species
Human

Comments

Comment Type Description
Similarity Contains PI3K/PI4K domain.
Similarity Contains PIK helical domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000687 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
156564405 RefSeq NP_005017 1044 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Identical Sequences to LMP000687 proteins

Reference Database Accession Length Protein Name
GI:156564405 GenBank AGF20803.1 1044 Sequence 6 from patent US 8367830
GI:156564405 GenBank AIC49397.1 1044 PIK3CD, partial [synthetic construct]
GI:156564405 RefSeq XP_006710749.1 1044 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [Homo sapiens]
GI:156564405 RefSeq XP_006710750.1 1044 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4 [Homo sapiens]
GI:156564405 RefSeq XP_006710751.1 1044 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [Homo sapiens]
GI:156564405 RefSeq XP_006710752.1 1044 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6 [Homo sapiens]

Related Sequences to LMP000687 proteins

Reference Database Accession Length Protein Name
GI:156564405 GenBank AAC25677.1 1044 phosphatidylinositol 3-kinase catalytic subunit p110delta [Homo sapiens]
GI:156564405 GenBank AAW07070.1 1044 Sequence 2 from patent US 6800620
GI:156564405 GenBank AFG80573.1 1044 Sequence 2 from patent US 8138195
GI:156564405 GenBank AGU24120.1 1044 Sequence 2 from patent US 8492389
GI:156564405 GenBank AHL55939.1 1044 Sequence 3 from patent US 8642604
GI:156564405 GenBank AHL63319.1 1044 Sequence 2 from patent US 8653077